LMP1-mediated glycolysis induces myeloid-derived suppressor cell expansion in nasopharyngeal carcinoma

Myeloid-derived suppressor cells (MDSCs) are expanded in tumor microenvironments, including that of Epstein-Barr virus (EBV)-associated nasopharyngeal carcinoma (NPC). The link between MDSC expansion and EBV infection in NPC is unclear. Here, we show that EBV latent membrane protein 1 (LMP1) promote...

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Veröffentlicht in:	PLoS pathogens 2017-07, Vol.13 (7), p.e1006503-e1006503
Hauptverfasser:	Cai, Ting-Ting, Ye, Shu-Biao, Liu, Yi-Na, He, Jia, Chen, Qiu-Yan, Mai, Hai-Qiang, Zhang, Chuan-Xia, Cui, Jun, Zhang, Xiao-Shi, Busson, Pierre, Zeng, Yi-Xin, Li, Jiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Biodegradation Biology and Life Sciences Cancer Carcinoma - genetics Carcinoma - metabolism Carcinoma - physiopathology Carcinoma - virology Cell Line, Tumor Cell Proliferation Collaboration Cyclooxygenase-2 Degradation Epstein-Barr virus Epstein-Barr Virus Infections - genetics Epstein-Barr Virus Infections - metabolism Epstein-Barr Virus Infections - physiopathology Epstein-Barr Virus Infections - virology Expansion Gene expression Gene Expression Regulation, Neoplastic Genetic aspects Glucose transporter GLUT1 protein Glycolysis Granulocyte-macrophage colony-stimulating factor Granulocyte-Macrophage Colony-Stimulating Factor - genetics Granulocyte-Macrophage Colony-Stimulating Factor - metabolism Health aspects Herpesvirus 4, Human - genetics Herpesvirus 4, Human - metabolism Host-Pathogen Interactions Humans Immunology Immunosuppression In vitro methods and tests Infections Inflammasomes Innate immunity Interleukin 1 Interleukin 6 Interleukin-6 - genetics Interleukin-6 - metabolism Laboratories Latent membrane protein 1 Life Sciences Medicine Medicine and Health Sciences Membrane proteins Microbiology and Parasitology Microenvironments Mitochondria Myeloid-Derived Suppressor Cells - cytology Myeloid-Derived Suppressor Cells - metabolism Nasopharyngeal cancer Nasopharyngeal Carcinoma Nasopharyngeal Neoplasms - genetics Nasopharyngeal Neoplasms - metabolism Nasopharyngeal Neoplasms - physiopathology Nasopharyngeal Neoplasms - virology Oncology Physical Sciences Physiological aspects Proteins Research and Analysis Methods Roles Signal Transduction Suppressor cells Throat cancer Tumors Ubiquitination Viral Matrix Proteins - genetics Viral Matrix Proteins - metabolism Virology Viruses
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