Schistosome egg antigens, including the glycoprotein IPSE/alpha-1, trigger the development of regulatory B cells

Infection with the helminth Schistosoma (S.) mansoni drives the development of interleukin (IL)-10-producing regulatory B (Breg) cells in mice and man, which have the capacity to reduce experimental allergic airway inflammation and are thus of high therapeutic interest. However, both the involved an...

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Veröffentlicht in:	PLoS pathogens 2017-07, Vol.13 (7), p.e1006539-e1006539
Hauptverfasser:	Haeberlein, Simone, Obieglo, Katja, Ozir-Fazalalikhan, Arifa, Chayé, Mathilde A M, Veninga, Henrike, van der Vlugt, Luciën E P M, Voskamp, Astrid, Boon, Louis, den Haan, Joke M M, Westerhof, Lotte B, Wilbers, Ruud H P, Schots, Arjen, Schramm, Gabriele, Hokke, Cornelis H, Smits, Hermelijn H
Format:	Artikel
Sprache:	eng
Schlagworte:	Acidification Animals Antigens Antigens, Helminth - genetics Antigens, Helminth - immunology B cells B-Lymphocytes, Regulatory - immunology Biology and Life Sciences Bisphosphonates CD1d antigen CD40 antigen CD86 antigen Clodronic acid Compartments Cytokines Dendritic cells Depletion Egg Proteins - genetics Egg Proteins - immunology Eggs EPS Female Fluke infections Flukes Funding Glycoproteins Grants Helminth Proteins - genetics Helminth Proteins - immunology Humans Immunology In vitro methods and tests Infections Inflammatory diseases Interleukin 10 Interleukin-10 - immunology Laboratorium voor Nematologie Laboratory of Nematology Liposomes Lymphocytes B Lymphocytes T Macrophages Medicine and Health Sciences Mice Mice, Inbred C57BL Ovum - immunology Parasitology Physiological aspects Plant sciences Plants Research and Analysis Methods Respiratory tract Respiratory tract diseases Schistosoma mansoni - genetics Schistosoma mansoni - immunology Schistosomiasis mansoni - genetics Schistosomiasis mansoni - immunology Schistosomiasis mansoni - parasitology Spleen Tobacco
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