Unraveling the genetic diversity and phylogeny of Leishmania RNA virus 1 strains of infected Leishmania isolates circulating in French Guiana

Leishmania RNA virus type 1 (LRV1) is an endosymbiont of some Leishmania (Vianna) species in South America. Presence of LRV1 in parasites exacerbates disease severity in animal models and humans, related to a disproportioned innate immune response, and is correlated with drug treatment failures in h...

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Veröffentlicht in:	PLoS neglected tropical diseases 2017-07, Vol.11 (7), p.e0005764-e0005764
Hauptverfasser:	Tirera, Sourakhata, Ginouves, Marine, Donato, Damien, Caballero, Ignacio S, Bouchier, Christiane, Lavergne, Anne, Bourreau, Eliane, Mosnier, Emilie, Vantilcke, Vincent, Couppié, Pierre, Prevot, Ghislaine, Lacoste, Vincent
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Analysis Animal diseases Animal models Biodiversity Bioinformatics Biology and Life Sciences Cluster Analysis Clustering Clusters Computer and Information Sciences Conserved sequence Cutaneous leishmaniasis Defence mechanisms Diagnostic systems Drugs Evolution Evolutionary genetics Failures Female French Guiana Funding Genetic diversity Genetic Variation Genetics Genome, Viral Genomes Genotyping Health aspects History Human genetics Humans Identification Immune response Immune system Immunity Infections Innate immunity Laboratories Leishmania Leishmania - isolation & purification Leishmania - virology Leishmaniasis Leishmaniasis - parasitology Leishmaniavirus Leishmaniavirus - classification Leishmaniavirus - genetics Leishmaniavirus - isolation & purification Life Sciences Male Management Medicine Medicine and Health Sciences Microbiological strains Microbiology and Parasitology Middle Aged Molecular biology Multinational space ventures Nucleic acids Nucleotide sequence Parasites Parasitic diseases Parasitology Pathogenesis Phylogenetics Phylogeny Research and analysis methods Ribonucleic acid RNA RNA viruses RNA, Viral RNA, Viral - genetics Sequence Alignment Sequence Analysis, DNA Sequencing Strains Strains (organisms) Taxonomy Tropical diseases Variability Vector-borne diseases Virology Viruses Young Adult
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