Persistent damaged bases in DNA allow mutagenic break repair in Escherichia coli

Bacteria, yeast and human cancer cells possess mechanisms of mutagenesis upregulated by stress responses. Stress-inducible mutagenesis potentially accelerates adaptation, and may provide important models for mutagenesis that drives cancers, host pathogen interactions, antibiotic resistance and possi...

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Veröffentlicht in:	PLoS genetics 2017-07, Vol.13 (7), p.e1006733
Hauptverfasser:	Moore, Jessica M, Correa, Raul, Rosenberg, Susan M, Hastings, P J
Format:	Artikel
Sprache:	eng
Schlagworte:	8-Hydroxydeoxyguanosine Alkylation Antibiotic resistance Antibiotics Bacteria Bacterial Proteins - biosynthesis Bacterial Proteins - genetics Biology and life sciences Cancer Damage prevention Deoxyguanine Nucleotides - genetics Dimers DNA Breaks, Double-Stranded - drug effects DNA damage DNA Damage - drug effects DNA polymerase DNA repair DNA Repair - genetics DNA-directed DNA polymerase DNA-Directed DNA Polymerase - biosynthesis DNA-Directed DNA Polymerase - genetics Double-strand break repair Drug resistance Drug Resistance, Bacterial - genetics Escherichia coli Escherichia coli - drug effects Escherichia coli - genetics Escherichia coli Proteins - biosynthesis Escherichia coli Proteins - genetics Fidelity Gene Expression Regulation, Bacterial - drug effects Genetic aspects Guanines Health aspects Host-Pathogen Interactions - genetics Mismatch repair Mutagenesis Mutagenesis - genetics Mutation Mutation - genetics Observations Oxidation Physical Sciences Reactive oxygen species Reactive Oxygen Species - metabolism Regulators Sigma Factor - biosynthesis Sigma Factor - genetics SOS response SOS Response, Genetics - genetics Stress, Physiological - genetics Yeast
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