The sero-epidemiology of Rift Valley fever in people in the Lake Victoria Basin of western Kenya
Rift Valley fever virus (RVFV) is a zoonotic arbovirus affecting livestock and people. This study was conducted in western Kenya where RVFV outbreaks have not previously been reported. The aims were to document the seroprevalence and risk factors for RVFV antibodies in a community-based sample from...
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| Veröffentlicht in: | PLoS neglected tropical diseases 2017-07, Vol.11 (7), p.e0005731 |
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| creator | Cook, Elizabeth Anne Jessie Grossi-Soyster, Elysse Noel de Glanville, William Anson Thomas, Lian Francesca Kariuki, Samuel Bronsvoort, Barend Mark de Clare Wamae, Claire Njeri LaBeaud, Angelle Desiree Fèvre, Eric Maurice |
| description | Rift Valley fever virus (RVFV) is a zoonotic arbovirus affecting livestock and people. This study was conducted in western Kenya where RVFV outbreaks have not previously been reported. The aims were to document the seroprevalence and risk factors for RVFV antibodies in a community-based sample from western Kenya and compare this with slaughterhouse workers in the same region who are considered a high-risk group for RVFV exposure. The study was conducted in western Kenya between July 2010 and November 2012. Individuals were recruited from randomly selected homesteads and a census of slaughterhouses. Structured questionnaire tools were used to collect information on demographic data, health, and risk factors for zoonotic disease exposure. Indirect ELISA on serum samples determined seropositivity to RVFV. Risk factor analysis for RVFV seropositivity was conducted using multi-level logistic regression. A total of 1861 individuals were sampled in 384 homesteads. The seroprevalence of RVFV in the community was 0.8% (95% CI 0.5-1.3). The variables significantly associated with RVFV seropositivity in the community were increasing age (OR 1.2; 95% CI 1.1-1.4, p |
| doi_str_mv | 10.1371/journal.pntd.0005731 |
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This study was conducted in western Kenya where RVFV outbreaks have not previously been reported. The aims were to document the seroprevalence and risk factors for RVFV antibodies in a community-based sample from western Kenya and compare this with slaughterhouse workers in the same region who are considered a high-risk group for RVFV exposure. The study was conducted in western Kenya between July 2010 and November 2012. Individuals were recruited from randomly selected homesteads and a census of slaughterhouses. Structured questionnaire tools were used to collect information on demographic data, health, and risk factors for zoonotic disease exposure. Indirect ELISA on serum samples determined seropositivity to RVFV. Risk factor analysis for RVFV seropositivity was conducted using multi-level logistic regression. A total of 1861 individuals were sampled in 384 homesteads. The seroprevalence of RVFV in the community was 0.8% (95% CI 0.5-1.3). The variables significantly associated with RVFV seropositivity in the community were increasing age (OR 1.2; 95% CI 1.1-1.4, p<0.001), and slaughtering cattle at the homestead (OR 3.3; 95% CI 1.0-10.5, p = 0.047). A total of 553 slaughterhouse workers were sampled in 84 ruminant slaughterhouses. The seroprevalence of RVFV in slaughterhouse workers was 2.5% (95% CI 1.5-4.2). Being the slaughterman, the person who cuts the animal's throat (OR 3.5; 95% CI 1.0-12.1, p = 0.047), was significantly associated with RVFV seropositivity. This study investigated and compared the epidemiology of RVFV between community members and slaughterhouse workers in western Kenya. The data demonstrate that slaughtering animals is a risk factor for RVFV seropositivity and that slaughterhouse workers are a high-risk group for RVFV seropositivity in this environment. These risk factors have been previously reported in other studies providing further evidence for RVFV circulation in western Kenya.</description><identifier>ISSN: 1935-2735</identifier><identifier>ISSN: 1935-2727</identifier><identifier>EISSN: 1935-2735</identifier><identifier>DOI: 10.1371/journal.pntd.0005731</identifier><identifier>PMID: 28686589</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Abattoirs ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Analysis ; Animals ; Antibodies ; Antibodies, Viral - blood ; Biology and life sciences ; Cattle - virology ; Census ; Censuses ; Circulation ; Coccidioidomycosis ; Communities ; Community ; Councils ; Demographics ; Ecological risk assessment ; ELISA ; Enzyme-Linked Immunosorbent Assay ; Epidemics ; Epidemiology ; Exposure ; Factor analysis ; Female ; Fever ; Funding ; Health risk assessment ; Health risks ; Humans ; Immunology ; Infections ; Inland waters ; Kenya - epidemiology ; Lake basins ; Lakes ; Landsat satellites ; Livestock ; Logistic Models ; Male ; Medical research ; Medicine and health sciences ; Middle Aged ; Occupational Exposure ; Open access ; Outbreaks ; Pediatrics ; People and Places ; Pharynx ; Regression analysis ; Regressions ; Research and Analysis Methods ; Rift Valley fever ; Rift Valley Fever - epidemiology ; Rift Valley fever virus ; Risk analysis ; Risk Factors ; Risk groups ; Seroepidemiologic Studies ; Serology ; Serum ; Slaughter ; Surveys ; Tropical diseases ; Vector-borne diseases ; Viral diseases ; Viruses ; Workers ; Young Adult ; Zoonoses ; Zoonoses - epidemiology</subject><ispartof>PLoS neglected tropical diseases, 2017-07, Vol.11 (7), p.e0005731</ispartof><rights>COPYRIGHT 2017 Public Library of Science</rights><rights>2017 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Cook EAJ, Grossi-Soyster EN, de Glanville WA, Thomas LF, Kariuki S, Bronsvoort BMdC, et al. (2017) The sero-epidemiology of Rift Valley fever in people in the Lake Victoria Basin of western Kenya. PLoS Negl Trop Dis 11(7): e0005731. https://doi.org/10.1371/journal.pntd.0005731</rights><rights>2017 Cook et al 2017 Cook et al</rights><rights>2017 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Cook EAJ, Grossi-Soyster EN, de Glanville WA, Thomas LF, Kariuki S, Bronsvoort BMdC, et al. (2017) The sero-epidemiology of Rift Valley fever in people in the Lake Victoria Basin of western Kenya. PLoS Negl Trop Dis 11(7): e0005731. https://doi.org/10.1371/journal.pntd.0005731</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c624t-ed4a75fe3a163d58af0e83daf862797e1425f869e26b9280a06a85b8803b43683</citedby><cites>FETCH-LOGICAL-c624t-ed4a75fe3a163d58af0e83daf862797e1425f869e26b9280a06a85b8803b43683</cites><orcidid>0000-0001-6081-8363</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5517073/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5517073/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2100,2926,23865,27923,27924,53790,53792,79371,79372</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28686589$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>McElroy, Anita K.</contributor><creatorcontrib>Cook, Elizabeth Anne Jessie</creatorcontrib><creatorcontrib>Grossi-Soyster, Elysse Noel</creatorcontrib><creatorcontrib>de Glanville, William Anson</creatorcontrib><creatorcontrib>Thomas, Lian Francesca</creatorcontrib><creatorcontrib>Kariuki, Samuel</creatorcontrib><creatorcontrib>Bronsvoort, Barend Mark de Clare</creatorcontrib><creatorcontrib>Wamae, Claire Njeri</creatorcontrib><creatorcontrib>LaBeaud, Angelle Desiree</creatorcontrib><creatorcontrib>Fèvre, Eric Maurice</creatorcontrib><title>The sero-epidemiology of Rift Valley fever in people in the Lake Victoria Basin of western Kenya</title><title>PLoS neglected tropical diseases</title><addtitle>PLoS Negl Trop Dis</addtitle><description>Rift Valley fever virus (RVFV) is a zoonotic arbovirus affecting livestock and people. This study was conducted in western Kenya where RVFV outbreaks have not previously been reported. The aims were to document the seroprevalence and risk factors for RVFV antibodies in a community-based sample from western Kenya and compare this with slaughterhouse workers in the same region who are considered a high-risk group for RVFV exposure. The study was conducted in western Kenya between July 2010 and November 2012. Individuals were recruited from randomly selected homesteads and a census of slaughterhouses. Structured questionnaire tools were used to collect information on demographic data, health, and risk factors for zoonotic disease exposure. Indirect ELISA on serum samples determined seropositivity to RVFV. Risk factor analysis for RVFV seropositivity was conducted using multi-level logistic regression. A total of 1861 individuals were sampled in 384 homesteads. The seroprevalence of RVFV in the community was 0.8% (95% CI 0.5-1.3). The variables significantly associated with RVFV seropositivity in the community were increasing age (OR 1.2; 95% CI 1.1-1.4, p<0.001), and slaughtering cattle at the homestead (OR 3.3; 95% CI 1.0-10.5, p = 0.047). A total of 553 slaughterhouse workers were sampled in 84 ruminant slaughterhouses. The seroprevalence of RVFV in slaughterhouse workers was 2.5% (95% CI 1.5-4.2). Being the slaughterman, the person who cuts the animal's throat (OR 3.5; 95% CI 1.0-12.1, p = 0.047), was significantly associated with RVFV seropositivity. This study investigated and compared the epidemiology of RVFV between community members and slaughterhouse workers in western Kenya. The data demonstrate that slaughtering animals is a risk factor for RVFV seropositivity and that slaughterhouse workers are a high-risk group for RVFV seropositivity in this environment. These risk factors have been previously reported in other studies providing further evidence for RVFV circulation in western Kenya.</description><subject>Abattoirs</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Analysis</subject><subject>Animals</subject><subject>Antibodies</subject><subject>Antibodies, Viral - blood</subject><subject>Biology and life sciences</subject><subject>Cattle - virology</subject><subject>Census</subject><subject>Censuses</subject><subject>Circulation</subject><subject>Coccidioidomycosis</subject><subject>Communities</subject><subject>Community</subject><subject>Councils</subject><subject>Demographics</subject><subject>Ecological risk assessment</subject><subject>ELISA</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Epidemics</subject><subject>Epidemiology</subject><subject>Exposure</subject><subject>Factor analysis</subject><subject>Female</subject><subject>Fever</subject><subject>Funding</subject><subject>Health risk assessment</subject><subject>Health risks</subject><subject>Humans</subject><subject>Immunology</subject><subject>Infections</subject><subject>Inland waters</subject><subject>Kenya - epidemiology</subject><subject>Lake basins</subject><subject>Lakes</subject><subject>Landsat satellites</subject><subject>Livestock</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine and health sciences</subject><subject>Middle Aged</subject><subject>Occupational Exposure</subject><subject>Open access</subject><subject>Outbreaks</subject><subject>Pediatrics</subject><subject>People and Places</subject><subject>Pharynx</subject><subject>Regression analysis</subject><subject>Regressions</subject><subject>Research and Analysis Methods</subject><subject>Rift Valley fever</subject><subject>Rift Valley Fever - epidemiology</subject><subject>Rift Valley fever virus</subject><subject>Risk analysis</subject><subject>Risk Factors</subject><subject>Risk groups</subject><subject>Seroepidemiologic Studies</subject><subject>Serology</subject><subject>Serum</subject><subject>Slaughter</subject><subject>Surveys</subject><subject>Tropical diseases</subject><subject>Vector-borne diseases</subject><subject>Viral diseases</subject><subject>Viruses</subject><subject>Workers</subject><subject>Young Adult</subject><subject>Zoonoses</subject><subject>Zoonoses - 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sero-epidemiology of Rift Valley fever in people in the Lake Victoria Basin of western Kenya</title><author>Cook, Elizabeth Anne Jessie ; Grossi-Soyster, Elysse Noel ; de Glanville, William Anson ; Thomas, Lian Francesca ; Kariuki, Samuel ; Bronsvoort, Barend Mark de Clare ; Wamae, Claire Njeri ; LaBeaud, Angelle Desiree ; Fèvre, Eric Maurice</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c624t-ed4a75fe3a163d58af0e83daf862797e1425f869e26b9280a06a85b8803b43683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Abattoirs</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Analysis</topic><topic>Animals</topic><topic>Antibodies</topic><topic>Antibodies, Viral - blood</topic><topic>Biology and life sciences</topic><topic>Cattle - 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access</topic><topic>Outbreaks</topic><topic>Pediatrics</topic><topic>People and Places</topic><topic>Pharynx</topic><topic>Regression analysis</topic><topic>Regressions</topic><topic>Research and Analysis Methods</topic><topic>Rift Valley fever</topic><topic>Rift Valley Fever - epidemiology</topic><topic>Rift Valley fever virus</topic><topic>Risk analysis</topic><topic>Risk Factors</topic><topic>Risk groups</topic><topic>Seroepidemiologic Studies</topic><topic>Serology</topic><topic>Serum</topic><topic>Slaughter</topic><topic>Surveys</topic><topic>Tropical diseases</topic><topic>Vector-borne diseases</topic><topic>Viral diseases</topic><topic>Viruses</topic><topic>Workers</topic><topic>Young Adult</topic><topic>Zoonoses</topic><topic>Zoonoses - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cook, Elizabeth Anne Jessie</creatorcontrib><creatorcontrib>Grossi-Soyster, Elysse Noel</creatorcontrib><creatorcontrib>de Glanville, 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neglected tropical diseases</jtitle><addtitle>PLoS Negl Trop Dis</addtitle><date>2017-07-07</date><risdate>2017</risdate><volume>11</volume><issue>7</issue><spage>e0005731</spage><pages>e0005731-</pages><issn>1935-2735</issn><issn>1935-2727</issn><eissn>1935-2735</eissn><abstract>Rift Valley fever virus (RVFV) is a zoonotic arbovirus affecting livestock and people. This study was conducted in western Kenya where RVFV outbreaks have not previously been reported. The aims were to document the seroprevalence and risk factors for RVFV antibodies in a community-based sample from western Kenya and compare this with slaughterhouse workers in the same region who are considered a high-risk group for RVFV exposure. The study was conducted in western Kenya between July 2010 and November 2012. Individuals were recruited from randomly selected homesteads and a census of slaughterhouses. Structured questionnaire tools were used to collect information on demographic data, health, and risk factors for zoonotic disease exposure. Indirect ELISA on serum samples determined seropositivity to RVFV. Risk factor analysis for RVFV seropositivity was conducted using multi-level logistic regression. A total of 1861 individuals were sampled in 384 homesteads. The seroprevalence of RVFV in the community was 0.8% (95% CI 0.5-1.3). The variables significantly associated with RVFV seropositivity in the community were increasing age (OR 1.2; 95% CI 1.1-1.4, p<0.001), and slaughtering cattle at the homestead (OR 3.3; 95% CI 1.0-10.5, p = 0.047). A total of 553 slaughterhouse workers were sampled in 84 ruminant slaughterhouses. The seroprevalence of RVFV in slaughterhouse workers was 2.5% (95% CI 1.5-4.2). Being the slaughterman, the person who cuts the animal's throat (OR 3.5; 95% CI 1.0-12.1, p = 0.047), was significantly associated with RVFV seropositivity. This study investigated and compared the epidemiology of RVFV between community members and slaughterhouse workers in western Kenya. The data demonstrate that slaughtering animals is a risk factor for RVFV seropositivity and that slaughterhouse workers are a high-risk group for RVFV seropositivity in this environment. These risk factors have been previously reported in other studies providing further evidence for RVFV circulation in western Kenya.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>28686589</pmid><doi>10.1371/journal.pntd.0005731</doi><orcidid>https://orcid.org/0000-0001-6081-8363</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1935-2735 |
| ispartof | PLoS neglected tropical diseases, 2017-07, Vol.11 (7), p.e0005731 |
| issn | 1935-2735 1935-2727 1935-2735 |
| language | eng |
| recordid | cdi_plos_journals_1929413486 |
| source | PLoS; MEDLINE; DOAJ Directory of Open Access Journals; PubMed Central; EZB Electronic Journals Library; PubMed Central Open Access |
| subjects | Abattoirs Adolescent Adult Aged Aged, 80 and over Analysis Animals Antibodies Antibodies, Viral - blood Biology and life sciences Cattle - virology Census Censuses Circulation Coccidioidomycosis Communities Community Councils Demographics Ecological risk assessment ELISA Enzyme-Linked Immunosorbent Assay Epidemics Epidemiology Exposure Factor analysis Female Fever Funding Health risk assessment Health risks Humans Immunology Infections Inland waters Kenya - epidemiology Lake basins Lakes Landsat satellites Livestock Logistic Models Male Medical research Medicine and health sciences Middle Aged Occupational Exposure Open access Outbreaks Pediatrics People and Places Pharynx Regression analysis Regressions Research and Analysis Methods Rift Valley fever Rift Valley Fever - epidemiology Rift Valley fever virus Risk analysis Risk Factors Risk groups Seroepidemiologic Studies Serology Serum Slaughter Surveys Tropical diseases Vector-borne diseases Viral diseases Viruses Workers Young Adult Zoonoses Zoonoses - epidemiology |
| title | The sero-epidemiology of Rift Valley fever in people in the Lake Victoria Basin of western Kenya |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-10T15%3A52%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20sero-epidemiology%20of%20Rift%20Valley%20fever%20in%20people%20in%20the%20Lake%20Victoria%20Basin%20of%20western%20Kenya&rft.jtitle=PLoS%20neglected%20tropical%20diseases&rft.au=Cook,%20Elizabeth%20Anne%20Jessie&rft.date=2017-07-07&rft.volume=11&rft.issue=7&rft.spage=e0005731&rft.pages=e0005731-&rft.issn=1935-2735&rft.eissn=1935-2735&rft_id=info:doi/10.1371/journal.pntd.0005731&rft_dat=%3Cgale_plos_%3EA499694281%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1929413486&rft_id=info:pmid/28686589&rft_galeid=A499694281&rft_doaj_id=oai_doaj_org_article_3f55fa3ccce441a2a75c3ee3efe7020c&rfr_iscdi=true |