Zebrafish slc30a10 deficiency revealed a novel compensatory mechanism of Atp2c1 in maintaining manganese homeostasis

Recent studies found that mutations in the human SLC30A10 gene, which encodes a manganese (Mn) efflux transporter, are associated with hypermanganesemia with dystonia, polycythemia, and cirrhosis (HMDPC). However, the relationship between Mn metabolism and HMDPC is poorly understood, and no specific...

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Veröffentlicht in:	PLoS genetics 2017-07, Vol.13 (7), p.e1006892-e1006892
Hauptverfasser:	Xia, Zhidan, Wei, Jiayu, Li, Yingniang, Wang, Jia, Li, Wenwen, Wang, Kai, Hong, Xiaoli, Zhao, Lu, Chen, Caiyong, Min, Junxia, Wang, Fudi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine triphosphatase Animals Biology and Life Sciences Brain - metabolism Brain - pathology Calcium Calcium-Transporting ATPases - genetics Cation Transport Proteins - deficiency Cation Transport Proteins - genetics Chelation Children & youth Cirrhosis Collaboration CRISPR CRISPR-Cas Systems Dopamine Dopamine receptors Dystonia Embryos Ethylenediaminetetraacetic acids Fatty liver Fibrosis Food safety Funding Genotype HeLa Cells Homeostasis Homeostasis - genetics Hospitals Humans Infectious diseases Iron Life sciences Liver Liver cirrhosis Manganese Manganese (Nutrient) Manganese - metabolism Medical diagnosis Medicine Medicine and Health Sciences Metabolic Diseases - genetics Metabolic Diseases - metabolism Metabolic Diseases - pathology Metabolism Mutation Neurological diseases Neurotoxicity Nutrition Observations Physical Sciences Physiological aspects Polycythemia Public health Research and Analysis Methods Roles Software Steatosis Studies Supplements Zebrafish Zebrafish - genetics Zinc Transporter 8 γ-Aminobutyric acid
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