Plasma metabolomics reveals membrane lipids, aspartate/asparagine and nucleotide metabolism pathway differences associated with chloroquine resistance in Plasmodium vivax malaria

Chloroquine (CQ) is the main anti-schizontocidal drug used in the treatment of uncomplicated malaria caused by Plasmodium vivax. Chloroquine resistant P. vivax (PvCR) malaria in the Western Pacific region, Asia and in the Americas indicates a need for biomarkers of resistance to improve therapy and...

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Veröffentlicht in:	PloS one 2017-08, Vol.12 (8), p.e0182819-e0182819
Hauptverfasser:	Uppal, Karan, Salinas, Jorge L, Monteiro, Wuelton M, Val, Fernando, Cordy, Regina J, Liu, Ken, Melo, Gisely C, Siqueira, Andre M, Magalhaes, Belisa, Galinski, Mary R, Lacerda, Marcus V G, Jones, Dean P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Amino acids Asparagine Asparagine - metabolism Biological activity Biology and Life Sciences Biomarkers Care and treatment Causes of Chloroquine Chloroquine - pharmacology Chloroquine - therapeutic use Classification Cluster Analysis Comparative analysis Computational Biology - methods Development and progression Discriminant analysis Drug Resistance Enrichment Female Genetic aspects High resolution Humans Identification methods Lipid metabolism Lipids Malaria Malaria, Vivax - blood Malaria, Vivax - diagnosis Malaria, Vivax - drug therapy Malaria, Vivax - parasitology Male Medicine Medicine and Health Sciences Membrane Lipids Metabolic Networks and Pathways Metabolism Metabolome Metabolomics Metabolomics - methods Middle Aged Nucleotides - metabolism Parasitemia Parasites Pathogens Patients Phenotyping Physiological aspects Plasmas (physics) Plasmodium vivax Plasmodium vivax - drug effects Public health Regression analysis Vector-borne diseases Xenobiotics Young Adult
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