A prospective comparative assessment of the accuracy of the FibroScan in evaluating liver steatosis
Recent studies have demonstrated the utility of the FibroScan® device in diagnosing liver steatosis, but its usefulness has not been thoroughly appraised. We investigated the usefulness of the controlled attenuation parameter (CAP) in detecting and quantifying liver steatosis. A prospective analysis...
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| creator | Jun, Baek Gyu Park, Won Young Park, Eui Ju Jang, Jae Young Jeong, Soung Won Lee, Sae Hwan Kim, Sang Gyune Cha, Sang-Woo Kim, Young Seok Cho, Young Deok Kim, Hong Soo Kim, Boo Sung Jin, So Young Park, Suyeon |
| description | Recent studies have demonstrated the utility of the FibroScan® device in diagnosing liver steatosis, but its usefulness has not been thoroughly appraised. We investigated the usefulness of the controlled attenuation parameter (CAP) in detecting and quantifying liver steatosis.
A prospective analysis was applied to 79 chronic liver disease patients who underwent a liver biopsy, a FibroScan investigation, ultrasonography, and hepatic steatosis index (HSI). The presence and degree of steatosis as measured by the FibroScan device, ultrasonography and HSI were compared with the results for the liver biopsy tissue.
There was substantial concordance between the liver biopsy results and the CAP as evaluated by the kappa (κ) index test for detecting liver steatosis (κCAP = 0.77, P |
| doi_str_mv | 10.1371/journal.pone.0182784 |
| format | Article |
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A prospective analysis was applied to 79 chronic liver disease patients who underwent a liver biopsy, a FibroScan investigation, ultrasonography, and hepatic steatosis index (HSI). The presence and degree of steatosis as measured by the FibroScan device, ultrasonography and HSI were compared with the results for the liver biopsy tissue.
There was substantial concordance between the liver biopsy results and the CAP as evaluated by the kappa (κ) index test for detecting liver steatosis (κCAP = 0.77, P<0.001; κultrasonography = 0.60, P<0.001; κHSI = 0.47, P<0.001). The areas under the receiver operating characteristic curve (AUROCs) of the CAP, ultrasonography, and HSI were 0.899 [95% confidence interval (CI) = 0.826-0.972)], 0.859 (95% CI = 0.779-0.939), and 0.766 (95% CI = 0.655-0.877), respectively. The optimal CAP cutoff value for differentiating between normal and hepatic steatosis was 247 dB/m, which produced sensitivity and specificity values of 91.9% and 85.7%, respectively, as well as a positive predictive value of 85.0% and a negative predictive value of 92.3%.
The CAP produces results that are highly concordant with those of a liver biopsy in detecting steatosis. Therefore, the CAP is a noninvasive and reliable tool for evaluating liver steatosis, even in the early stages.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0182784</identifier><identifier>PMID: 28813448</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Accuracy ; Adult ; Animals ; Biology and Life Sciences ; Biopsy ; Care and treatment ; Confidence intervals ; Diagnosis ; Fatty liver ; Fatty Liver - diagnostic imaging ; Female ; Hepatitis ; Hepatology ; Hospitals ; Humans ; Internal medicine ; Lipidosis ; Liver ; Liver - diagnostic imaging ; Liver - pathology ; Liver diseases ; Liver Diseases - diagnostic imaging ; Medical equipment ; Medical imaging ; Medicine ; Medicine and Health Sciences ; Methods ; Middle Aged ; NMR ; Nuclear magnetic resonance ; Predictive Value of Tests ; Prospective Studies ; Research and Analysis Methods ; ROC Curve ; Sensitivity and Specificity ; Steatosis ; Ultrasonic imaging ; Ultrasonography - standards ; Ultrasound</subject><ispartof>PloS one, 2017-08, Vol.12 (8), p.e0182784-e0182784</ispartof><rights>COPYRIGHT 2017 Public Library of Science</rights><rights>2017 Jun et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2017 Jun et al 2017 Jun et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c758t-f01380278708dcb5453f1791e4a3c306ae94d632ed12f324f06c7339dd12cba3</citedby><cites>FETCH-LOGICAL-c758t-f01380278708dcb5453f1791e4a3c306ae94d632ed12f324f06c7339dd12cba3</cites><orcidid>0000-0003-4693-9542</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557594/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557594/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2095,2914,23846,27903,27904,53769,53771,79346,79347</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28813448$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Kim, Seung Up</contributor><creatorcontrib>Jun, Baek Gyu</creatorcontrib><creatorcontrib>Park, Won Young</creatorcontrib><creatorcontrib>Park, Eui Ju</creatorcontrib><creatorcontrib>Jang, Jae Young</creatorcontrib><creatorcontrib>Jeong, Soung Won</creatorcontrib><creatorcontrib>Lee, Sae Hwan</creatorcontrib><creatorcontrib>Kim, Sang Gyune</creatorcontrib><creatorcontrib>Cha, Sang-Woo</creatorcontrib><creatorcontrib>Kim, Young Seok</creatorcontrib><creatorcontrib>Cho, Young Deok</creatorcontrib><creatorcontrib>Kim, Hong Soo</creatorcontrib><creatorcontrib>Kim, Boo Sung</creatorcontrib><creatorcontrib>Jin, So Young</creatorcontrib><creatorcontrib>Park, Suyeon</creatorcontrib><title>A prospective comparative assessment of the accuracy of the FibroScan in evaluating liver steatosis</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Recent studies have demonstrated the utility of the FibroScan® device in diagnosing liver steatosis, but its usefulness has not been thoroughly appraised. We investigated the usefulness of the controlled attenuation parameter (CAP) in detecting and quantifying liver steatosis.
A prospective analysis was applied to 79 chronic liver disease patients who underwent a liver biopsy, a FibroScan investigation, ultrasonography, and hepatic steatosis index (HSI). The presence and degree of steatosis as measured by the FibroScan device, ultrasonography and HSI were compared with the results for the liver biopsy tissue.
There was substantial concordance between the liver biopsy results and the CAP as evaluated by the kappa (κ) index test for detecting liver steatosis (κCAP = 0.77, P<0.001; κultrasonography = 0.60, P<0.001; κHSI = 0.47, P<0.001). The areas under the receiver operating characteristic curve (AUROCs) of the CAP, ultrasonography, and HSI were 0.899 [95% confidence interval (CI) = 0.826-0.972)], 0.859 (95% CI = 0.779-0.939), and 0.766 (95% CI = 0.655-0.877), respectively. The optimal CAP cutoff value for differentiating between normal and hepatic steatosis was 247 dB/m, which produced sensitivity and specificity values of 91.9% and 85.7%, respectively, as well as a positive predictive value of 85.0% and a negative predictive value of 92.3%.
The CAP produces results that are highly concordant with those of a liver biopsy in detecting steatosis. Therefore, the CAP is a noninvasive and reliable tool for evaluating liver steatosis, even in the early stages.</description><subject>Accuracy</subject><subject>Adult</subject><subject>Animals</subject><subject>Biology and Life Sciences</subject><subject>Biopsy</subject><subject>Care and treatment</subject><subject>Confidence intervals</subject><subject>Diagnosis</subject><subject>Fatty liver</subject><subject>Fatty Liver - diagnostic imaging</subject><subject>Female</subject><subject>Hepatitis</subject><subject>Hepatology</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Internal medicine</subject><subject>Lipidosis</subject><subject>Liver</subject><subject>Liver - diagnostic imaging</subject><subject>Liver - pathology</subject><subject>Liver diseases</subject><subject>Liver Diseases - diagnostic imaging</subject><subject>Medical equipment</subject><subject>Medical imaging</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Methods</subject><subject>Middle Aged</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Predictive Value of Tests</subject><subject>Prospective Studies</subject><subject>Research and Analysis Methods</subject><subject>ROC Curve</subject><subject>Sensitivity and Specificity</subject><subject>Steatosis</subject><subject>Ultrasonic imaging</subject><subject>Ultrasonography - standards</subject><subject>Ultrasound</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk99v0zAQxyMEYmPwHyCIhITgocW_kjgvSNXEoNKkSWzi1bo4l9ZVEhfbqdh_j7umU4P2gPIQ-_L5fu273CXJW0rmlBf0y8YOrod2vrU9zgmVrJDiWXJOS85mOSP8-cn6LHnl_YaQjMs8f5mcMSkpF0KeJ3qRbp31W9TB7DDVttuCg4c1eI_ed9iH1DZpWMeI1oMDfX_cX5nK2VsNfWr6FHfQDlHZr9I2yl3qA0Kw3vjXyYsGWo9vxvdFcnf17e7yx-z65vvycnE900Umw6whlEsS0yiIrHWViYw3tCgpCuCakxywFHXOGdaUNZyJhuS64Lys415XwC-S9wfbbWu9GsvjFS1ZSTJCcxaJ5YGoLWzU1pkO3L2yYNRDwLqVAheMblE1CIzrQpakEqIQlSwBJRe0YKVEbLLo9XU8bag6rHUsk4N2Yjr90pu1WtmdyrKsyEoRDT6NBs7-HtAH1RmvsW2hRzvs780ZFTmReUQ__IM-nd1IrSAmYPrGxnP13lQtMkJyIXO295o_QcWnxs7o2EuNifGJ4PNEEJmAf8IKBu_V8vbn_7M3v6bsxxN2jdCGtbftEIzt_RQUB1DHRvUOm8ciU6L2o3CshtqPghpHIcrenf6gR9Gx9_lfSAQDlA</recordid><startdate>20170815</startdate><enddate>20170815</enddate><creator>Jun, Baek Gyu</creator><creator>Park, Won Young</creator><creator>Park, Eui Ju</creator><creator>Jang, Jae Young</creator><creator>Jeong, Soung Won</creator><creator>Lee, Sae Hwan</creator><creator>Kim, Sang Gyune</creator><creator>Cha, Sang-Woo</creator><creator>Kim, Young Seok</creator><creator>Cho, Young Deok</creator><creator>Kim, Hong Soo</creator><creator>Kim, Boo Sung</creator><creator>Jin, So Young</creator><creator>Park, Suyeon</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-4693-9542</orcidid></search><sort><creationdate>20170815</creationdate><title>A prospective comparative assessment of the accuracy of the FibroScan in evaluating liver steatosis</title><author>Jun, Baek Gyu ; Park, Won Young ; Park, Eui Ju ; Jang, Jae Young ; Jeong, Soung Won ; Lee, Sae Hwan ; Kim, Sang Gyune ; Cha, Sang-Woo ; Kim, Young Seok ; Cho, Young Deok ; Kim, Hong Soo ; Kim, Boo Sung ; Jin, So Young ; Park, Suyeon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c758t-f01380278708dcb5453f1791e4a3c306ae94d632ed12f324f06c7339dd12cba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Accuracy</topic><topic>Adult</topic><topic>Animals</topic><topic>Biology and Life Sciences</topic><topic>Biopsy</topic><topic>Care and treatment</topic><topic>Confidence intervals</topic><topic>Diagnosis</topic><topic>Fatty liver</topic><topic>Fatty Liver - diagnostic imaging</topic><topic>Female</topic><topic>Hepatitis</topic><topic>Hepatology</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Internal medicine</topic><topic>Lipidosis</topic><topic>Liver</topic><topic>Liver - diagnostic imaging</topic><topic>Liver - pathology</topic><topic>Liver diseases</topic><topic>Liver Diseases - diagnostic imaging</topic><topic>Medical equipment</topic><topic>Medical imaging</topic><topic>Medicine</topic><topic>Medicine and Health Sciences</topic><topic>Methods</topic><topic>Middle Aged</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Predictive Value of Tests</topic><topic>Prospective Studies</topic><topic>Research and Analysis Methods</topic><topic>ROC Curve</topic><topic>Sensitivity and Specificity</topic><topic>Steatosis</topic><topic>Ultrasonic imaging</topic><topic>Ultrasonography - standards</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jun, Baek Gyu</creatorcontrib><creatorcontrib>Park, Won Young</creatorcontrib><creatorcontrib>Park, Eui Ju</creatorcontrib><creatorcontrib>Jang, Jae Young</creatorcontrib><creatorcontrib>Jeong, Soung Won</creatorcontrib><creatorcontrib>Lee, Sae Hwan</creatorcontrib><creatorcontrib>Kim, Sang Gyune</creatorcontrib><creatorcontrib>Cha, Sang-Woo</creatorcontrib><creatorcontrib>Kim, Young Seok</creatorcontrib><creatorcontrib>Cho, Young Deok</creatorcontrib><creatorcontrib>Kim, Hong Soo</creatorcontrib><creatorcontrib>Kim, Boo Sung</creatorcontrib><creatorcontrib>Jin, So Young</creatorcontrib><creatorcontrib>Park, Suyeon</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection (ProQuest)</collection><collection>Natural Science Collection (ProQuest)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jun, Baek Gyu</au><au>Park, Won Young</au><au>Park, Eui Ju</au><au>Jang, Jae Young</au><au>Jeong, Soung Won</au><au>Lee, Sae Hwan</au><au>Kim, Sang Gyune</au><au>Cha, Sang-Woo</au><au>Kim, Young Seok</au><au>Cho, Young Deok</au><au>Kim, Hong Soo</au><au>Kim, Boo Sung</au><au>Jin, So Young</au><au>Park, Suyeon</au><au>Kim, Seung Up</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A prospective comparative assessment of the accuracy of the FibroScan in evaluating liver steatosis</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2017-08-15</date><risdate>2017</risdate><volume>12</volume><issue>8</issue><spage>e0182784</spage><epage>e0182784</epage><pages>e0182784-e0182784</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Recent studies have demonstrated the utility of the FibroScan® device in diagnosing liver steatosis, but its usefulness has not been thoroughly appraised. We investigated the usefulness of the controlled attenuation parameter (CAP) in detecting and quantifying liver steatosis.
A prospective analysis was applied to 79 chronic liver disease patients who underwent a liver biopsy, a FibroScan investigation, ultrasonography, and hepatic steatosis index (HSI). The presence and degree of steatosis as measured by the FibroScan device, ultrasonography and HSI were compared with the results for the liver biopsy tissue.
There was substantial concordance between the liver biopsy results and the CAP as evaluated by the kappa (κ) index test for detecting liver steatosis (κCAP = 0.77, P<0.001; κultrasonography = 0.60, P<0.001; κHSI = 0.47, P<0.001). The areas under the receiver operating characteristic curve (AUROCs) of the CAP, ultrasonography, and HSI were 0.899 [95% confidence interval (CI) = 0.826-0.972)], 0.859 (95% CI = 0.779-0.939), and 0.766 (95% CI = 0.655-0.877), respectively. The optimal CAP cutoff value for differentiating between normal and hepatic steatosis was 247 dB/m, which produced sensitivity and specificity values of 91.9% and 85.7%, respectively, as well as a positive predictive value of 85.0% and a negative predictive value of 92.3%.
The CAP produces results that are highly concordant with those of a liver biopsy in detecting steatosis. Therefore, the CAP is a noninvasive and reliable tool for evaluating liver steatosis, even in the early stages.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>28813448</pmid><doi>10.1371/journal.pone.0182784</doi><tpages>e0182784</tpages><orcidid>https://orcid.org/0000-0003-4693-9542</orcidid><oa>free_for_read</oa></addata></record> |
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| issn | 1932-6203 1932-6203 |
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| subjects | Accuracy Adult Animals Biology and Life Sciences Biopsy Care and treatment Confidence intervals Diagnosis Fatty liver Fatty Liver - diagnostic imaging Female Hepatitis Hepatology Hospitals Humans Internal medicine Lipidosis Liver Liver - diagnostic imaging Liver - pathology Liver diseases Liver Diseases - diagnostic imaging Medical equipment Medical imaging Medicine Medicine and Health Sciences Methods Middle Aged NMR Nuclear magnetic resonance Predictive Value of Tests Prospective Studies Research and Analysis Methods ROC Curve Sensitivity and Specificity Steatosis Ultrasonic imaging Ultrasonography - standards Ultrasound |
| title | A prospective comparative assessment of the accuracy of the FibroScan in evaluating liver steatosis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-25T02%3A01%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20prospective%20comparative%20assessment%20of%20the%20accuracy%20of%20the%20FibroScan%20in%20evaluating%20liver%20steatosis&rft.jtitle=PloS%20one&rft.au=Jun,%20Baek%20Gyu&rft.date=2017-08-15&rft.volume=12&rft.issue=8&rft.spage=e0182784&rft.epage=e0182784&rft.pages=e0182784-e0182784&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0182784&rft_dat=%3Cgale_plos_%3EA500648626%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1929050162&rft_id=info:pmid/28813448&rft_galeid=A500648626&rft_doaj_id=oai_doaj_org_article_fea23c7890b4474b89ae83417298eef5&rfr_iscdi=true |