Transcriptome analysis of PDGFRα+ cells identifies T-type Ca2+ channel CACNA1G as a new pathological marker for PDGFRα+ cell hyperplasia

Platelet-derived growth factor receptor alpha (PDGFRα)+ cells are distributed into distinct morphological groups within the serosal, muscular, and submucosal layers as well as the myenteric and deep muscular plexi. PDGFRα+ cells directly interact with interstitial cells of Cajal (ICC) and smooth mus...

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Veröffentlicht in:	PloS one 2017-08, Vol.12 (8), p.e0182265-e0182265
Hauptverfasser:	Ha, Se Eun, Lee, Moon Young, Kurahashi, Masaaki, Wei, Lai, Jorgensen, Brian G, Park, Chanjae, Park, Paul J, Redelman, Doug, Sasse, Kent C, Becker, Laren S, Sanders, Kenton M, Ro, Seungil
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biology Biology and Life Sciences Calcium Calcium channels (T-type) Calcium channels (voltage-gated) Calcium Channels, T-Type - genetics Calcium Channels, T-Type - metabolism Cell Dedifferentiation Cell Proliferation - genetics Cell Separation Colorectal cancer Colorectal carcinoma Crohn's disease Enzymes Fibroblasts Gastric motility Gastrointestinal diseases Gene expression Gene Expression Profiling Gene Expression Regulation Genome Genomes Growth factors Humans Hyperplasia Hypertrophy Interstitial cells Interstitial cells of Cajal Ion channels Ion Channels - genetics Ion Channels - metabolism Jejunum - metabolism Kinases Low voltage Medical research Medicine Medicine and Health Sciences Mice Motility Muscle, Smooth - metabolism Physical Sciences Physiology Platelet-derived growth factor Protein Isoforms - genetics Protein Isoforms - metabolism Protein kinase Receptor, Platelet-Derived Growth Factor alpha - metabolism Receptors Regulators Research and Analysis Methods RNA, Messenger - genetics RNA, Messenger - metabolism Rodents Small intestine Smooth muscle Transcription factors
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