New synthetic lipid antigens for rapid serological diagnosis of tuberculosis

During pulmonary tuberculosis (PTB) antibodies are generated to trehalose esters of mycolic acids which are cell wall lipids of Mycobacterium tuberculosis (Mtb). Attempts have been made to use these complex natural mixtures in serological tests for PTB diagnosis. The aim of this work was to determin...

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Veröffentlicht in:	PloS one 2017-08, Vol.12 (8), p.e0181414-e0181414
Hauptverfasser:	Jones, Alison, Pitts, Mark, Al Dulayymi, Juma'a R, Gibbons, James, Ramsay, Andrew, Goletti, Delia, Gwenin, Christopher D, Baird, Mark S
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Adult Algorithms Antibodies Antigens Antigens, Bacterial - chemistry Antigens, Bacterial - metabolism Biology and Life Sciences Cell culture Cell walls Demography Diagnosis Diagnostic systems Disease Enzyme-Linked Immunosorbent Assay Esters Female Health aspects Humans Immunoglobulins Immunology Infections Lipids Male Medical diagnosis Medicine and Health Sciences Methods Middle Aged Mycolic acids Mycolic Acids - chemistry Patients Physical Sciences Predictive Value of Tests Research and Analysis Methods Sensitivity Serologic Tests - methods Serological tests Smear Statistical analysis Statistical methods Trehalose Tuberculosis Tuberculosis, Pulmonary - blood Tuberculosis, Pulmonary - diagnosis Tuberculosis, Pulmonary - microbiology Young Adult
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