Genome-wide regulation of electro-acupuncture on the neural Stat5-loss-induced obese mice

Acupuncture is reported to be effective in treating obesity related illnesses, but its mechanism is still unclear. To investigate this mechanism we applied electro-acupuncture (EA) in a mouse model of obesity and used RNA-seq to identify molecular consequences. Deletion of the transcription factor S...

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Veröffentlicht in:	PloS one 2017-08, Vol.12 (8), p.e0181948-e0181948
Hauptverfasser:	Fu, Shu-Ping, Hong, Hao, Lu, Sheng-Feng, Hu, Chen-Jun, Xu, Hou-Xi, Li, Qian, Yu, Mei-Ling, Ou, Chen, Meng, Jian-Zhong, Wang, Tian-Lin, Hennighausen, Lothar, Zhu, Bing-Mei
Format:	Artikel
Sprache:	eng
Schlagworte:	Acupuncture Adaptation, Physiological Adipose tissue Adipose Tissue, White - metabolism Animals Biology and Life Sciences Body weight Care and treatment Cholesterol Cold Temperature Down-Regulation - genetics Electroacupuncture Endurance Energy Metabolism - genetics Epididymis - metabolism Gene expression Gene Expression Profiling Genome Genomes Health aspects Hypothalamus Hypothalamus - metabolism Illnesses Kinases Male Medicine and Health Sciences Mice Mice, Knockout Mice, Obese Molecular Sequence Annotation Obesity Phenotype Ping Fu Reproducibility of Results Ribonucleic acid RNA RNA sequencing Rodents Sequence Analysis, RNA Stat5 protein STAT5 Transcription Factor - deficiency STAT5 Transcription Factor - metabolism Up-Regulation - genetics Weight reduction
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