Prognostic factors and outcomes in Japanese lung transplant candidates with interstitial lung disease
Young patients with advanced interstitial lung disease (ILD) are potential candidates for cadaveric lung transplantation. This study aimed to examine clinical features, outcomes, and prognostic factors in Japanese ILD patients awaiting lung transplantation. We investigated the clinical features and...
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| Veröffentlicht in: | PloS one 2017-08, Vol.12 (8), p.e0183171-e0183171 |
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| creator | Ikezoe, Kohei Handa, Tomohiro Tanizawa, Kiminobu Chen-Yoshikawa, Toyofumi F Kubo, Takeshi Aoyama, Akihiro Motoyama, Hideki Hijiya, Kyoko Tokuda, Shinsaku Nakatsuka, Yoshinari Yamamoto, Yuko Oshima, Ayako Harashima, Shin-Ichi Nagai, Sonoko Hirai, Toyohiro Date, Hiroshi Chin, Kazuo |
| description | Young patients with advanced interstitial lung disease (ILD) are potential candidates for cadaveric lung transplantation. This study aimed to examine clinical features, outcomes, and prognostic factors in Japanese ILD patients awaiting lung transplantation.
We investigated the clinical features and outcomes of 77 consecutive candidates with ILD who were referred to Kyoto University Hospital and subsequently actively listed for lung transplant in the Japan Organ Transplant Network between 2010 and 2014.
Of the 77 candidates, 33 had idiopathic pulmonary fibrosis (IPF) and 15 had unclassifiable ILD. During the observational period, 23 patients (30%) received lung transplantations and 49 patients (64%) died before transplantation. Of the 33 patients with IPF, 13 (39%) had a family history of ILD and 13 (39%) had an "inconsistent with usual interstitial pneumonia pattern" on high-resolution computed tomography (HRCT). The median survival time from registration was 16.7 months, and mortality was similar among patients with IPF, unclassifiable ILD, and other ILDs. Using a multivariate stepwise Cox proportional hazards model, 6-min walking distance was shown to be an independent prognostic factor in candidates with ILD (per 10 m, hazard ratio (HR): 0.97; 95% confidence interval (CI): 0.95-0.99, p |
| doi_str_mv | 10.1371/journal.pone.0183171 |
| format | Article |
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We investigated the clinical features and outcomes of 77 consecutive candidates with ILD who were referred to Kyoto University Hospital and subsequently actively listed for lung transplant in the Japan Organ Transplant Network between 2010 and 2014.
Of the 77 candidates, 33 had idiopathic pulmonary fibrosis (IPF) and 15 had unclassifiable ILD. During the observational period, 23 patients (30%) received lung transplantations and 49 patients (64%) died before transplantation. Of the 33 patients with IPF, 13 (39%) had a family history of ILD and 13 (39%) had an "inconsistent with usual interstitial pneumonia pattern" on high-resolution computed tomography (HRCT). The median survival time from registration was 16.7 months, and mortality was similar among patients with IPF, unclassifiable ILD, and other ILDs. Using a multivariate stepwise Cox proportional hazards model, 6-min walking distance was shown to be an independent prognostic factor in candidates with ILD (per 10 m, hazard ratio (HR): 0.97; 95% confidence interval (CI): 0.95-0.99, p<0.01), while lower body mass index (HR: 0.83; 95% CI: 0.72-0.95, p < 0.01) independently contributed to mortality in patients with IPF.
Japanese patients with ILD awaiting transplantation had very poor outcomes regardless of their specific diagnosis. A substantial percentage of IPF patients had an atypical HRCT pattern. 6-min walking distance in ILD patients and body mass index in IPF patients were independent predictors of mortality.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0183171</identifier><identifier>PMID: 28800589</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Biology and Life Sciences ; Biomarkers - analysis ; Body mass ; Body Mass Index ; Cadavers ; Carbon monoxide ; Care and treatment ; Cohort Studies ; Computed tomography ; Confidence intervals ; Development and progression ; Diagnosis ; Female ; Fibrosis ; Genetics ; Hazards ; Health aspects ; High resolution ; Hospitals ; Humans ; Idiopathic Pulmonary Fibrosis - diagnosis ; Idiopathic Pulmonary Fibrosis - mortality ; Idiopathic Pulmonary Fibrosis - pathology ; Idiopathic Pulmonary Fibrosis - surgery ; Interstitial lung diseases ; Intubation ; Lung diseases ; Lung Diseases, Interstitial - diagnosis ; Lung Diseases, Interstitial - mortality ; Lung Diseases, Interstitial - pathology ; Lung Diseases, Interstitial - surgery ; Lung Transplantation ; Male ; Medical prognosis ; Medicine ; Medicine and Health Sciences ; Middle Aged ; Mortality ; Nutrition ; Patients ; Physical Sciences ; Pneumonia ; Prognosis ; Proportional Hazards Models ; Pulmonary arteries ; Pulmonary fibrosis ; Quality of life ; Respiratory Function Tests ; Surgery ; Thoracic surgery ; Tomography, X-Ray Computed ; Transplantation ; Transplants & implants ; University graduates ; Walking ; Xenografts</subject><ispartof>PloS one, 2017-08, Vol.12 (8), p.e0183171-e0183171</ispartof><rights>COPYRIGHT 2017 Public Library of Science</rights><rights>2017 Ikezoe et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2017 Ikezoe et al 2017 Ikezoe et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-69a92a9842a3f2e51d1c68d9ca52d4a49096b7cd0ce3e8c0ebabbaeedd0d39793</citedby><cites>FETCH-LOGICAL-c692t-69a92a9842a3f2e51d1c68d9ca52d4a49096b7cd0ce3e8c0ebabbaeedd0d39793</cites><orcidid>0000-0002-3378-6412</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5553985/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5553985/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28800589$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>de Jesus Perez, Vinicio A.</contributor><creatorcontrib>Ikezoe, Kohei</creatorcontrib><creatorcontrib>Handa, Tomohiro</creatorcontrib><creatorcontrib>Tanizawa, Kiminobu</creatorcontrib><creatorcontrib>Chen-Yoshikawa, Toyofumi F</creatorcontrib><creatorcontrib>Kubo, Takeshi</creatorcontrib><creatorcontrib>Aoyama, Akihiro</creatorcontrib><creatorcontrib>Motoyama, Hideki</creatorcontrib><creatorcontrib>Hijiya, Kyoko</creatorcontrib><creatorcontrib>Tokuda, Shinsaku</creatorcontrib><creatorcontrib>Nakatsuka, Yoshinari</creatorcontrib><creatorcontrib>Yamamoto, Yuko</creatorcontrib><creatorcontrib>Oshima, Ayako</creatorcontrib><creatorcontrib>Harashima, Shin-Ichi</creatorcontrib><creatorcontrib>Nagai, Sonoko</creatorcontrib><creatorcontrib>Hirai, Toyohiro</creatorcontrib><creatorcontrib>Date, Hiroshi</creatorcontrib><creatorcontrib>Chin, Kazuo</creatorcontrib><title>Prognostic factors and outcomes in Japanese lung transplant candidates with interstitial lung disease</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Young patients with advanced interstitial lung disease (ILD) are potential candidates for cadaveric lung transplantation. This study aimed to examine clinical features, outcomes, and prognostic factors in Japanese ILD patients awaiting lung transplantation.
We investigated the clinical features and outcomes of 77 consecutive candidates with ILD who were referred to Kyoto University Hospital and subsequently actively listed for lung transplant in the Japan Organ Transplant Network between 2010 and 2014.
Of the 77 candidates, 33 had idiopathic pulmonary fibrosis (IPF) and 15 had unclassifiable ILD. During the observational period, 23 patients (30%) received lung transplantations and 49 patients (64%) died before transplantation. Of the 33 patients with IPF, 13 (39%) had a family history of ILD and 13 (39%) had an "inconsistent with usual interstitial pneumonia pattern" on high-resolution computed tomography (HRCT). The median survival time from registration was 16.7 months, and mortality was similar among patients with IPF, unclassifiable ILD, and other ILDs. Using a multivariate stepwise Cox proportional hazards model, 6-min walking distance was shown to be an independent prognostic factor in candidates with ILD (per 10 m, hazard ratio (HR): 0.97; 95% confidence interval (CI): 0.95-0.99, p<0.01), while lower body mass index (HR: 0.83; 95% CI: 0.72-0.95, p < 0.01) independently contributed to mortality in patients with IPF.
Japanese patients with ILD awaiting transplantation had very poor outcomes regardless of their specific diagnosis. A substantial percentage of IPF patients had an atypical HRCT pattern. 6-min walking distance in ILD patients and body mass index in IPF patients were independent predictors of mortality.</description><subject>Adult</subject><subject>Biology and Life Sciences</subject><subject>Biomarkers - analysis</subject><subject>Body mass</subject><subject>Body Mass Index</subject><subject>Cadavers</subject><subject>Carbon monoxide</subject><subject>Care and treatment</subject><subject>Cohort Studies</subject><subject>Computed tomography</subject><subject>Confidence intervals</subject><subject>Development and progression</subject><subject>Diagnosis</subject><subject>Female</subject><subject>Fibrosis</subject><subject>Genetics</subject><subject>Hazards</subject><subject>Health aspects</subject><subject>High resolution</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Idiopathic Pulmonary Fibrosis - diagnosis</subject><subject>Idiopathic Pulmonary Fibrosis - mortality</subject><subject>Idiopathic Pulmonary Fibrosis - pathology</subject><subject>Idiopathic Pulmonary Fibrosis - surgery</subject><subject>Interstitial lung diseases</subject><subject>Intubation</subject><subject>Lung diseases</subject><subject>Lung Diseases, Interstitial - diagnosis</subject><subject>Lung Diseases, Interstitial - mortality</subject><subject>Lung Diseases, Interstitial - pathology</subject><subject>Lung Diseases, Interstitial - surgery</subject><subject>Lung Transplantation</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Nutrition</subject><subject>Patients</subject><subject>Physical Sciences</subject><subject>Pneumonia</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Pulmonary arteries</subject><subject>Pulmonary fibrosis</subject><subject>Quality of life</subject><subject>Respiratory Function Tests</subject><subject>Surgery</subject><subject>Thoracic surgery</subject><subject>Tomography, X-Ray Computed</subject><subject>Transplantation</subject><subject>Transplants & implants</subject><subject>University 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factors and outcomes in Japanese lung transplant candidates with interstitial lung disease</title><author>Ikezoe, Kohei ; Handa, Tomohiro ; Tanizawa, Kiminobu ; Chen-Yoshikawa, Toyofumi F ; Kubo, Takeshi ; Aoyama, Akihiro ; Motoyama, Hideki ; Hijiya, Kyoko ; Tokuda, Shinsaku ; Nakatsuka, Yoshinari ; Yamamoto, Yuko ; Oshima, Ayako ; Harashima, Shin-Ichi ; Nagai, Sonoko ; Hirai, Toyohiro ; Date, Hiroshi ; Chin, Kazuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-69a92a9842a3f2e51d1c68d9ca52d4a49096b7cd0ce3e8c0ebabbaeedd0d39793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Biology and Life Sciences</topic><topic>Biomarkers - analysis</topic><topic>Body mass</topic><topic>Body Mass Index</topic><topic>Cadavers</topic><topic>Carbon monoxide</topic><topic>Care and treatment</topic><topic>Cohort Studies</topic><topic>Computed 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Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ikezoe, Kohei</au><au>Handa, Tomohiro</au><au>Tanizawa, Kiminobu</au><au>Chen-Yoshikawa, Toyofumi F</au><au>Kubo, Takeshi</au><au>Aoyama, Akihiro</au><au>Motoyama, Hideki</au><au>Hijiya, Kyoko</au><au>Tokuda, Shinsaku</au><au>Nakatsuka, Yoshinari</au><au>Yamamoto, Yuko</au><au>Oshima, Ayako</au><au>Harashima, Shin-Ichi</au><au>Nagai, Sonoko</au><au>Hirai, Toyohiro</au><au>Date, Hiroshi</au><au>Chin, Kazuo</au><au>de Jesus Perez, Vinicio A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic factors and outcomes in Japanese lung transplant candidates with interstitial lung disease</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2017-08-11</date><risdate>2017</risdate><volume>12</volume><issue>8</issue><spage>e0183171</spage><epage>e0183171</epage><pages>e0183171-e0183171</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Young patients with advanced interstitial lung disease (ILD) are potential candidates for cadaveric lung transplantation. This study aimed to examine clinical features, outcomes, and prognostic factors in Japanese ILD patients awaiting lung transplantation.
We investigated the clinical features and outcomes of 77 consecutive candidates with ILD who were referred to Kyoto University Hospital and subsequently actively listed for lung transplant in the Japan Organ Transplant Network between 2010 and 2014.
Of the 77 candidates, 33 had idiopathic pulmonary fibrosis (IPF) and 15 had unclassifiable ILD. During the observational period, 23 patients (30%) received lung transplantations and 49 patients (64%) died before transplantation. Of the 33 patients with IPF, 13 (39%) had a family history of ILD and 13 (39%) had an "inconsistent with usual interstitial pneumonia pattern" on high-resolution computed tomography (HRCT). The median survival time from registration was 16.7 months, and mortality was similar among patients with IPF, unclassifiable ILD, and other ILDs. Using a multivariate stepwise Cox proportional hazards model, 6-min walking distance was shown to be an independent prognostic factor in candidates with ILD (per 10 m, hazard ratio (HR): 0.97; 95% confidence interval (CI): 0.95-0.99, p<0.01), while lower body mass index (HR: 0.83; 95% CI: 0.72-0.95, p < 0.01) independently contributed to mortality in patients with IPF.
Japanese patients with ILD awaiting transplantation had very poor outcomes regardless of their specific diagnosis. A substantial percentage of IPF patients had an atypical HRCT pattern. 6-min walking distance in ILD patients and body mass index in IPF patients were independent predictors of mortality.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>28800589</pmid><doi>10.1371/journal.pone.0183171</doi><tpages>e0183171</tpages><orcidid>https://orcid.org/0000-0002-3378-6412</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2017-08, Vol.12 (8), p.e0183171-e0183171 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1927973323 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adult Biology and Life Sciences Biomarkers - analysis Body mass Body Mass Index Cadavers Carbon monoxide Care and treatment Cohort Studies Computed tomography Confidence intervals Development and progression Diagnosis Female Fibrosis Genetics Hazards Health aspects High resolution Hospitals Humans Idiopathic Pulmonary Fibrosis - diagnosis Idiopathic Pulmonary Fibrosis - mortality Idiopathic Pulmonary Fibrosis - pathology Idiopathic Pulmonary Fibrosis - surgery Interstitial lung diseases Intubation Lung diseases Lung Diseases, Interstitial - diagnosis Lung Diseases, Interstitial - mortality Lung Diseases, Interstitial - pathology Lung Diseases, Interstitial - surgery Lung Transplantation Male Medical prognosis Medicine Medicine and Health Sciences Middle Aged Mortality Nutrition Patients Physical Sciences Pneumonia Prognosis Proportional Hazards Models Pulmonary arteries Pulmonary fibrosis Quality of life Respiratory Function Tests Surgery Thoracic surgery Tomography, X-Ray Computed Transplantation Transplants & implants University graduates Walking Xenografts |
| title | Prognostic factors and outcomes in Japanese lung transplant candidates with interstitial lung disease |
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