Pitx3 and En1 determine the size and molecular programming of the dopaminergic neuronal pool

Mesodiencephalic dopaminergic (mdDA) neurons are located in the ventral midbrain. These neurons form the substantia nigra (SNc) and the ventral tegmental area (VTA). Two transcription factors that play important roles in the process of terminal differentiation and subset-specification of mdDA neuron...

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Veröffentlicht in:	PloS one 2017-08, Vol.12 (8), p.e0182421-e0182421
Hauptverfasser:	Kouwenhoven, Willemieke M, von Oerthel, Lars, Smidt, Marten P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biology and Life Sciences Breeding Cell fate Cell Survival Cellular Reprogramming Cholecystokinin Differentiation Dopamine Dopamine receptors Dopaminergic Neurons - cytology Dopaminergic Neurons - metabolism Embryo, Mammalian - metabolism Female Green Fluorescent Proteins - metabolism Homeobox Homeobox genes Homeodomain Proteins - metabolism Life sciences Male Medicine and Health Sciences Mesencephalon Mesencephalon - cytology Metabolism Mice Mutation - genetics Neurons Nuclear receptors Nurr1 protein Otx2 protein Polymerase Chain Reaction Rodents Studies Substantia nigra Transcription factors Transcription Factors - metabolism Tyrosine 3-Monooxygenase - metabolism Ventral tegmentum
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