Mesenchymal stromal cells (MSC) from JAK2+ myeloproliferative neoplasms differ from normal MSC and contribute to the maintenance of neoplastic hematopoiesis

There is evidence of continuous bidirectional cross-talk between malignant cells and bone marrow-derived mesenchymal stromal cells (BM-MSC), which favors the emergence and progression of myeloproliferative neoplastic (MPN) diseases. In the current work we have compared the function and gene expressi...

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Veröffentlicht in:	PloS one 2017-08, Vol.12 (8), p.e0182470-e0182470
Hauptverfasser:	Ramos, Teresa L, Sánchez-Abarca, Luis Ignacio, Rosón-Burgo, Beatriz, Redondo, Alba, Rico, Ana, Preciado, Silvia, Ortega, Rebeca, Rodríguez, Concepción, Muntión, Sandra, Hernández-Hernández, Ángel, De Las Rivas, Javier, González, Marcos, González Porras, José Ramón, Del Cañizo, Consuelo, Sánchez-Guijo, Fermín
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Apoptosis Biology and Life Sciences Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Bone marrow CD105 antigen CD44 antigen CD73 antigen CD90 antigen Cell Cycle Cell Line, Tumor Cell survival Cells (biology) Coculture Techniques Colonies Colony-forming cells Differentiation Extracellular matrix Female Fibroblasts Fluorescence Gene Expression Genes Hematologic Neoplasms - blood Hematologic Neoplasms - enzymology Hematologic Neoplasms - pathology Hematopoiesis Hematopoietic stem cells Humans Janus kinase 2 Janus Kinase 2 - metabolism Maintenance Male Medical prognosis Medical research Medicine and Health Sciences Mesenchymal stem cells Mesenchymal Stromal Cells - physiology Mesenchyme Middle Aged Mutation Neoplasia Neoplasms NF-κB protein Patients Research and Analysis Methods Stem cells Stromal cells Tumors
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