Pre-existing weakness is critical for the occurrence of postoperative cognitive dysfunction in mice of the same age

Occurrence of postoperative cognitive dysfunction (POCD) is age-dependent and heterogenous. Factors deciding the occurrence of POCD in patients of the same age undergone same surgeries remain unclear. Here we investigated the effects of pre-existing weakness on the occurrence of POCD in mice of the...

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Veröffentlicht in:	PloS one 2017-08, Vol.12 (8), p.e0182471-e0182471
Hauptverfasser:	Tang, Yujie, Wang, Xueqin, Zhang, Shuibing, Duan, Shangchun, Qing, Wenxiang, Chen, Gong, Ye, Feng, Le, Yuan, Ouyang, Wen
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Anesthesiology Animal cognition Animals Biology and Life Sciences Brain research Cognitive ability Cognitive disorders Cognitive Dysfunction - metabolism Cognitive Dysfunction - physiopathology Cyclic AMP response element-binding protein Disease Susceptibility Executive function Experiments Gene expression Glutamic acid receptors (ionotropic) Hippocampus - drug effects Hippocampus - metabolism Hippocampus - physiopathology House mouse Inflammation Injection Interleukin 1 Learning Lipopolysaccharides Lipopolysaccharides - pharmacology Male Medicine and Health Sciences Memory Mice Mice, Inbred C57BL Mortality N-Methyl-D-aspartic acid receptors Open-field behavior Oxidative stress Patients Postoperative complications Postoperative Complications - metabolism Postoperative Complications - physiopathology Reactive Oxygen Species - metabolism Receptors, N-Methyl-D-Aspartate - metabolism Research and Analysis Methods Risk factors Rodents Studies Surgery Synaptophysin Tumor necrosis factor
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