Novel application of the published kinase inhibitor set to identify therapeutic targets and pathways in triple negative breast cancer subtypes

Triple negative breast cancers (TNBCs) have high recurrence and metastasis rates. Acquisition of a mesenchymal morphology and phenotype in addition to driving migration is a consequential process that promotes metastasis. Although some kinases are known to regulate a mesenchymal phenotype, the role...

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Veröffentlicht in:	PloS one 2017-08, Vol.12 (8), p.e0177802-e0177802
Hauptverfasser:	Matossian, Margarite D, Elliott, Steven, Hoang, Van T, Burks, Hope E, Phamduy, Theresa B, Chrisey, Douglas B, Zuercher, William J, Drewry, David H, Wells, Carrow, Collins-Burow, Bridgette, Burow, Matthew E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biology and Life Sciences Biotechnology Breast cancer Cancer metastasis Care and treatment Cell Line, Tumor Cell morphology Cell Movement - drug effects Cell Transdifferentiation - drug effects Cytology Development and progression Drug Screening Assays, Antitumor Enzyme inhibitors Epithelial Cells - drug effects Epithelial Cells - pathology Gene expression Genetic aspects Genomics Genotype & phenotype Growth factors Health aspects Hematology Humans Inhibitors Kinases Medical screening Medicine Medicine and Health Sciences Mesenchyme Mesoderm - drug effects Mesoderm - pathology Metastases Metastasis Mice Molecular Targeted Therapy Oncology Pharmacy Phenotype Phosphotransferases Physical Sciences Polymerase chain reaction Prevention Protein Kinase Inhibitors - pharmacology Protein Kinase Inhibitors - therapeutic use Research and Analysis Methods Small Molecule Libraries - pharmacology Small Molecule Libraries - therapeutic use Stem cells Survival analysis Target acquisition Target recognition Transcription Triple Negative Breast Neoplasms - drug therapy Triple Negative Breast Neoplasms - enzymology Triple Negative Breast Neoplasms - pathology Xenograft Model Antitumor Assays
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