ACE phenotyping in human heart

Angiotensin-converting enzyme (ACE), which metabolizes many peptides and plays a key role in blood pressure regulation and vascular remodeling, is expressed as a type-1 membrane glycoprotein on the surface of different cells, including endothelial cells of the heart. We hypothesized that the local c...

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Veröffentlicht in:	PloS one 2017-08, Vol.12 (8), p.e0181976-e0181976
Hauptverfasser:	Tikhomirova, Victoria E, Kost, Olga A, Kryukova, Olga V, Golukhova, Elena Z, Bulaeva, Naida I, Zholbaeva, Aigerim Z, Bokeria, Leo A, Garcia, Joe G N, Danilov, Sergei M
Format:	Artikel
Sprache:	eng
Schlagworte:	ACE inhibitors Angiotensin converting enzyme Angiotensin-converting enzyme inhibitors Animals Atria Binding Biology and Life Sciences Blood Blood pressure Cardiac arrhythmia Chromatography Conformation Effectors Endothelial cells Enzymes Epitopes Fibrillation Genetic aspects Glycoproteins Glycosylation Health sciences Heart Heart Atria - metabolism Heart surgery Humans Inhibitors Lung - metabolism Lungs Male Medicine and Health Sciences Organ Specificity Organs Pathogenesis Peptides Peptidyl-dipeptidase A Peptidyl-Dipeptidase A - metabolism pH effects Phenotype Phenotyping Physical Sciences Physiological aspects Rats Rats, Wistar Rodents Substrate specificity Tissues
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