HBV infection in untreated HIV-infected adults in Maputo, Mozambique
© 2017 Chambal et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. BACKGROUND: HIV/ HBV coinfected patients a...
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| Veröffentlicht in: | PloS one 2017-07, Vol.12 (7), p.e0181836-e0181836 |
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| creator | Chambal, Lúcia Mabalane Gudo, Eduardo Samo Carimo, Awa Corte Real, Rita Mabunda, Nédio Maueia, Cremildo Vubil, Adolfo Zicai, Ana Flora Bhatt, Nilesh Antunes, Francisco |
| description | © 2017 Chambal et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
BACKGROUND: HIV/ HBV coinfected patients are at high risk of developing chronic HBV infection, liver cirrhosis and hepatocellular carcinoma. In Mozambique, where HIV prevalence is one of the highest in the world, HIV-infected patients are scarcely characterized in terms of HBV coinfection and 3TC-resistance mutations profile. METHODS: To characterize ART-naïve HIV-infected adults, with and without HBV coinfection, a cross-sectional study was conducted between May and November 2012 in two health centers from Maputo city, Mozambique. Subjects were consecutively enrolled in the study and, then, tested for hepatitis B surface antigen (HBsAg). Moreover, CD4+ T cells count, HBV DNA in plasma, HBV genotyping and 3TC-resistance mutations profile of HBV were assessed in HIV/HBV coinfected patients. RESULTS: In total, 518 patients were enrolled in the study. The median age was 33 years old and 66.8% were women. The median CD4+ T cells count was 361 cells/mm3 and 47 (9.1%) were coinfected with HBV. Out of 46 coinfected patients, 24 (55.2%) had HBV DNA ≥ 20 - < 20 000 and 12 (26.1%) had HBV-DNA ≥20 000. APRI > 2.0 was reported in 4.3% of coinfected and 1.7% of monoinfected patients (p = 0.228), while FIB-4 > 3.25 was reported in 4.4% of coinfected and 1.3% of monoinfected patients (p = 0.112). Genotype A was the most frequent, identified in 25/27 (92.6%) patients, whereas genotype E was present in 2/27 (7.4%) patients. No patient had 3TC-resistance mutations. CONCLUSIONS: This study showed that HBV coinfection was prevalent among ART-naïve HIV-infected adults in Mozambique. Overall, these data highlight the importance of screening HBV coinfection as an integrated measure of HIV routine care to improve health conditions and treatment of HIV/HBV coinfected patients.
This work was funded by Ministry of Health of Mozambique and by ViiV Healthcare Portugal. |
| doi_str_mv | 10.1371/journal.pone.0181836 |
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BACKGROUND: HIV/ HBV coinfected patients are at high risk of developing chronic HBV infection, liver cirrhosis and hepatocellular carcinoma. In Mozambique, where HIV prevalence is one of the highest in the world, HIV-infected patients are scarcely characterized in terms of HBV coinfection and 3TC-resistance mutations profile. METHODS: To characterize ART-naïve HIV-infected adults, with and without HBV coinfection, a cross-sectional study was conducted between May and November 2012 in two health centers from Maputo city, Mozambique. Subjects were consecutively enrolled in the study and, then, tested for hepatitis B surface antigen (HBsAg). Moreover, CD4+ T cells count, HBV DNA in plasma, HBV genotyping and 3TC-resistance mutations profile of HBV were assessed in HIV/HBV coinfected patients. RESULTS: In total, 518 patients were enrolled in the study. The median age was 33 years old and 66.8% were women. The median CD4+ T cells count was 361 cells/mm3 and 47 (9.1%) were coinfected with HBV. Out of 46 coinfected patients, 24 (55.2%) had HBV DNA ≥ 20 - < 20 000 and 12 (26.1%) had HBV-DNA ≥20 000. APRI > 2.0 was reported in 4.3% of coinfected and 1.7% of monoinfected patients (p = 0.228), while FIB-4 > 3.25 was reported in 4.4% of coinfected and 1.3% of monoinfected patients (p = 0.112). Genotype A was the most frequent, identified in 25/27 (92.6%) patients, whereas genotype E was present in 2/27 (7.4%) patients. No patient had 3TC-resistance mutations. CONCLUSIONS: This study showed that HBV coinfection was prevalent among ART-naïve HIV-infected adults in Mozambique. Overall, these data highlight the importance of screening HBV coinfection as an integrated measure of HIV routine care to improve health conditions and treatment of HIV/HBV coinfected patients.
This work was funded by Ministry of Health of Mozambique and by ViiV Healthcare Portugal.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0181836</identifier><identifier>PMID: 28759595</identifier><language>eng</language><publisher>United States: PLOS</publisher><subject>Acquired immune deficiency syndrome ; Adult ; Adults ; AIDS ; Antiretroviral drugs ; Biology and Life Sciences ; Care and treatment ; CD4 antigen ; CD4-Positive T-Lymphocytes - cytology ; Chronic infection ; Cirrhosis ; Cohort Studies ; Coinfection - epidemiology ; Cross-Sectional Studies ; Deoxyribonucleic acid ; Disease Progression ; DNA ; DNA, Viral - blood ; Drug Resistance, Viral - genetics ; Female ; Genetic Variation ; Genotype ; Genotyping ; Hepatitis ; Hepatitis B ; Hepatitis B surface antigen ; Hepatitis B Surface Antigens - blood ; Hepatitis B virus - genetics ; Hepatitis B, Chronic - complications ; Hepatitis B, Chronic - virology ; Hepatocellular carcinoma ; HIV ; HIV Infections - complications ; HIV Infections - virology ; Human immunodeficiency virus ; Humans ; Liver ; Liver cirrhosis ; Lymphocytes ; Lymphocytes T ; Male ; Medicine and Health Sciences ; Middle Aged ; Mozambique ; Mutation ; Patients ; People and Places ; Prevalence ; Risk Factors ; Social Class ; Viruses</subject><ispartof>PloS one, 2017-07, Vol.12 (7), p.e0181836-e0181836</ispartof><rights>COPYRIGHT 2017 Public Library of Science</rights><rights>2017 Chambal et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2017 Chambal et al 2017 Chambal et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c718t-9fd8471b21fd769001abf98831fe405aac6a999974c9c6d1fe5a518485975bc3</citedby><cites>FETCH-LOGICAL-c718t-9fd8471b21fd769001abf98831fe405aac6a999974c9c6d1fe5a518485975bc3</cites><orcidid>0000-0001-7932-1154</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536281/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536281/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,862,883,2098,2917,23849,27907,27908,53774,53776,79351,79352</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28759595$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Blackard, Jason</contributor><creatorcontrib>Chambal, Lúcia Mabalane</creatorcontrib><creatorcontrib>Gudo, Eduardo Samo</creatorcontrib><creatorcontrib>Carimo, Awa</creatorcontrib><creatorcontrib>Corte Real, Rita</creatorcontrib><creatorcontrib>Mabunda, Nédio</creatorcontrib><creatorcontrib>Maueia, Cremildo</creatorcontrib><creatorcontrib>Vubil, Adolfo</creatorcontrib><creatorcontrib>Zicai, Ana Flora</creatorcontrib><creatorcontrib>Bhatt, Nilesh</creatorcontrib><creatorcontrib>Antunes, Francisco</creatorcontrib><title>HBV infection in untreated HIV-infected adults in Maputo, Mozambique</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>© 2017 Chambal et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
BACKGROUND: HIV/ HBV coinfected patients are at high risk of developing chronic HBV infection, liver cirrhosis and hepatocellular carcinoma. In Mozambique, where HIV prevalence is one of the highest in the world, HIV-infected patients are scarcely characterized in terms of HBV coinfection and 3TC-resistance mutations profile. METHODS: To characterize ART-naïve HIV-infected adults, with and without HBV coinfection, a cross-sectional study was conducted between May and November 2012 in two health centers from Maputo city, Mozambique. Subjects were consecutively enrolled in the study and, then, tested for hepatitis B surface antigen (HBsAg). Moreover, CD4+ T cells count, HBV DNA in plasma, HBV genotyping and 3TC-resistance mutations profile of HBV were assessed in HIV/HBV coinfected patients. RESULTS: In total, 518 patients were enrolled in the study. The median age was 33 years old and 66.8% were women. The median CD4+ T cells count was 361 cells/mm3 and 47 (9.1%) were coinfected with HBV. Out of 46 coinfected patients, 24 (55.2%) had HBV DNA ≥ 20 - < 20 000 and 12 (26.1%) had HBV-DNA ≥20 000. APRI > 2.0 was reported in 4.3% of coinfected and 1.7% of monoinfected patients (p = 0.228), while FIB-4 > 3.25 was reported in 4.4% of coinfected and 1.3% of monoinfected patients (p = 0.112). Genotype A was the most frequent, identified in 25/27 (92.6%) patients, whereas genotype E was present in 2/27 (7.4%) patients. No patient had 3TC-resistance mutations. CONCLUSIONS: This study showed that HBV coinfection was prevalent among ART-naïve HIV-infected adults in Mozambique. Overall, these data highlight the importance of screening HBV coinfection as an integrated measure of HIV routine care to improve health conditions and treatment of HIV/HBV coinfected patients.
This work was funded by Ministry of Health of Mozambique and by ViiV Healthcare Portugal.</description><subject>Acquired immune deficiency syndrome</subject><subject>Adult</subject><subject>Adults</subject><subject>AIDS</subject><subject>Antiretroviral drugs</subject><subject>Biology and Life Sciences</subject><subject>Care and treatment</subject><subject>CD4 antigen</subject><subject>CD4-Positive T-Lymphocytes - cytology</subject><subject>Chronic infection</subject><subject>Cirrhosis</subject><subject>Cohort Studies</subject><subject>Coinfection - epidemiology</subject><subject>Cross-Sectional Studies</subject><subject>Deoxyribonucleic acid</subject><subject>Disease Progression</subject><subject>DNA</subject><subject>DNA, Viral - blood</subject><subject>Drug Resistance, Viral - genetics</subject><subject>Female</subject><subject>Genetic Variation</subject><subject>Genotype</subject><subject>Genotyping</subject><subject>Hepatitis</subject><subject>Hepatitis B</subject><subject>Hepatitis B surface antigen</subject><subject>Hepatitis B Surface Antigens - blood</subject><subject>Hepatitis B virus - genetics</subject><subject>Hepatitis B, Chronic - complications</subject><subject>Hepatitis B, Chronic - virology</subject><subject>Hepatocellular carcinoma</subject><subject>HIV</subject><subject>HIV Infections - complications</subject><subject>HIV Infections - virology</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Liver</subject><subject>Liver cirrhosis</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>Male</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Mozambique</subject><subject>Mutation</subject><subject>Patients</subject><subject>People and Places</subject><subject>Prevalence</subject><subject>Risk Factors</subject><subject>Social 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infection in untreated HIV-infected adults in Maputo, Mozambique</title><author>Chambal, Lúcia Mabalane ; Gudo, Eduardo Samo ; Carimo, Awa ; Corte Real, Rita ; Mabunda, Nédio ; Maueia, Cremildo ; Vubil, Adolfo ; Zicai, Ana Flora ; Bhatt, Nilesh ; Antunes, Francisco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c718t-9fd8471b21fd769001abf98831fe405aac6a999974c9c6d1fe5a518485975bc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Acquired immune deficiency syndrome</topic><topic>Adult</topic><topic>Adults</topic><topic>AIDS</topic><topic>Antiretroviral drugs</topic><topic>Biology and Life Sciences</topic><topic>Care and treatment</topic><topic>CD4 antigen</topic><topic>CD4-Positive T-Lymphocytes - cytology</topic><topic>Chronic infection</topic><topic>Cirrhosis</topic><topic>Cohort Studies</topic><topic>Coinfection - epidemiology</topic><topic>Cross-Sectional 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Jason</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HBV infection in untreated HIV-infected adults in Maputo, Mozambique</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2017-07-31</date><risdate>2017</risdate><volume>12</volume><issue>7</issue><spage>e0181836</spage><epage>e0181836</epage><pages>e0181836-e0181836</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>© 2017 Chambal et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
BACKGROUND: HIV/ HBV coinfected patients are at high risk of developing chronic HBV infection, liver cirrhosis and hepatocellular carcinoma. In Mozambique, where HIV prevalence is one of the highest in the world, HIV-infected patients are scarcely characterized in terms of HBV coinfection and 3TC-resistance mutations profile. METHODS: To characterize ART-naïve HIV-infected adults, with and without HBV coinfection, a cross-sectional study was conducted between May and November 2012 in two health centers from Maputo city, Mozambique. Subjects were consecutively enrolled in the study and, then, tested for hepatitis B surface antigen (HBsAg). Moreover, CD4+ T cells count, HBV DNA in plasma, HBV genotyping and 3TC-resistance mutations profile of HBV were assessed in HIV/HBV coinfected patients. RESULTS: In total, 518 patients were enrolled in the study. The median age was 33 years old and 66.8% were women. The median CD4+ T cells count was 361 cells/mm3 and 47 (9.1%) were coinfected with HBV. Out of 46 coinfected patients, 24 (55.2%) had HBV DNA ≥ 20 - < 20 000 and 12 (26.1%) had HBV-DNA ≥20 000. APRI > 2.0 was reported in 4.3% of coinfected and 1.7% of monoinfected patients (p = 0.228), while FIB-4 > 3.25 was reported in 4.4% of coinfected and 1.3% of monoinfected patients (p = 0.112). Genotype A was the most frequent, identified in 25/27 (92.6%) patients, whereas genotype E was present in 2/27 (7.4%) patients. No patient had 3TC-resistance mutations. CONCLUSIONS: This study showed that HBV coinfection was prevalent among ART-naïve HIV-infected adults in Mozambique. Overall, these data highlight the importance of screening HBV coinfection as an integrated measure of HIV routine care to improve health conditions and treatment of HIV/HBV coinfected patients.
This work was funded by Ministry of Health of Mozambique and by ViiV Healthcare Portugal.</abstract><cop>United States</cop><pub>PLOS</pub><pmid>28759595</pmid><doi>10.1371/journal.pone.0181836</doi><tpages>e0181836</tpages><orcidid>https://orcid.org/0000-0001-7932-1154</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2017-07, Vol.12 (7), p.e0181836-e0181836 |
| issn | 1932-6203 1932-6203 |
| language | eng |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Acquired immune deficiency syndrome Adult Adults AIDS Antiretroviral drugs Biology and Life Sciences Care and treatment CD4 antigen CD4-Positive T-Lymphocytes - cytology Chronic infection Cirrhosis Cohort Studies Coinfection - epidemiology Cross-Sectional Studies Deoxyribonucleic acid Disease Progression DNA DNA, Viral - blood Drug Resistance, Viral - genetics Female Genetic Variation Genotype Genotyping Hepatitis Hepatitis B Hepatitis B surface antigen Hepatitis B Surface Antigens - blood Hepatitis B virus - genetics Hepatitis B, Chronic - complications Hepatitis B, Chronic - virology Hepatocellular carcinoma HIV HIV Infections - complications HIV Infections - virology Human immunodeficiency virus Humans Liver Liver cirrhosis Lymphocytes Lymphocytes T Male Medicine and Health Sciences Middle Aged Mozambique Mutation Patients People and Places Prevalence Risk Factors Social Class Viruses |
| title | HBV infection in untreated HIV-infected adults in Maputo, Mozambique |
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