DNA-PKcs controls calcineurin mediated IL-2 production in T lymphocytes

Loss of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) activity in mammals results in severe combined immuno-deficiency (SCID). This SCID phenotype has been postulated to be due solely to the function of DNA-PKcs in V(D)J recombination, a process critical for lymphocyte maturation. Howeve...

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Veröffentlicht in:	PloS one 2017-07, Vol.12 (7), p.e0181608-e0181608
Hauptverfasser:	Kim Wiese, Ara, Schluterman Burdine, Marie, Turnage, Richard H, Tackett, Alan J, Burdine, Lyle J
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus Analysis Biochemistry Biology and Life Sciences Cabin1 protein Calcineurin Calcineurin - physiology Care and treatment Catalysis Cell cycle CHK2 protein Cytokines Deoxyribonucleic acid DNA DNA-dependent protein kinase Gene Expression Genetic aspects Humans Inhibitors Interleukin 2 Interleukin-2 - biosynthesis Interleukin-2 - genetics Interleukin-2 - secretion Jurkat Cells Kinases Lymphocytes Lymphocytes T Mammals Maturation Medicine and Health Sciences Molecular biology NF-AT protein NFATC Transcription Factors - metabolism Nuclei Oligopeptides - genetics Oligopeptides - metabolism Phosphorylation Plasmids Protein kinase Protein kinase C Protein Processing, Post-Translational Protein Stability Proteins Research and Analysis Methods Severe combined immunodeficiency Signal transduction Surgery T cell receptors Transcriptional Activation Translocation V(D)J recombination
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