Macromolecular biosynthetic parameters and metabolic profile in different life stages of Leishmania braziliensis: Amastigotes as a functionally less active stage

It was recently hypothesized that Leishmania amastigotes could constitute a semi-quiescent stage characterized by low replication and reduced metabolic activity. This concept developed with Leishmania (Leishmania) mexicana and Leishmania (Leishmania) major models might explain numerous clinical and...

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Veröffentlicht in:	PloS one 2017-07, Vol.12 (7), p.e0180532-e0180532
Hauptverfasser:	Jara, Marlene, Berg, Maya, Caljon, Guy, de Muylder, Geraldine, Cuypers, Bart, Castillo, Denis, Maes, Ilse, Orozco, María Del Carmen, Vanaerschot, Manu, Dujardin, Jean-Claude, Arevalo, Jorge
Format:	Artikel
Sprache:	eng
Schlagworte:	Abundance Activation Adenosine Diphosphate - metabolism Adenosine Triphosphate - metabolism Amastigotes Amino acids Animals Biology Biology and Life Sciences Biosynthesis Biosynthetic Pathways Cells, Cultured Chemotherapy Female Gene expression Genetic aspects Heat resistance Humboldt, Alexander von (1769-1859) In vitro methods and tests Intracellular Laboratory animals Leishmania Leishmania braziliensis - growth & development Leishmania braziliensis - metabolism Leishmania infantum Leishmania mexicana Leishmaniasis, Cutaneous - parasitology Lipids Macromolecules Medicine Medicine and Health Sciences Metabolism Metabolites Metabolome Metabolomics Mice, Inbred BALB C Parasites Parasitic diseases Parasitology Penicillin Phospholipids Promastigotes Proteins Protozoa Protozoan Proteins - analysis Protozoan Proteins - metabolism Ribonucleic acid Ribosomal proteins Ribosomal Proteins - analysis Ribosomal Proteins - metabolism RNA RNA, Protozoan - analysis RNA, Protozoan - metabolism rRNA 18S rRNA 28S Sterols Studies Trypanosoma cruzi
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