Role of HTRA1 in bone formation and regeneration: In vitro and in vivo evaluation

The role of mammalian high temperature requirement protease A1 (HTRA1) in somatic stem cell differentiation and mineralized matrix formation remains controversial, having been demonstrated to impart either anti- or pro-osteogenic effects, depending on the in vitro cell model used. The aim of this st...

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Veröffentlicht in:	PloS one 2017-07, Vol.12 (7), p.e0181600-e0181600
Hauptverfasser:	Filliat, Gladys, Mirsaidi, Ali, Tiaden, André N, Kuhn, Gisela A, Weber, Franz E, Oka, Chio, Richards, Peter J
Format:	Artikel
Sprache:	eng
Schlagworte:	Ablation Adipogenesis - physiology Analysis Animals Biocompatibility Biology and Life Sciences Biomarkers Biomedical materials Bone growth Bone marrow Bone morphogenetic protein 2 Bone Morphogenetic Protein 2 - metabolism Calcification, Physiologic - physiology Cell culture Cell differentiation Cell Differentiation - physiology Cell Line Chondrogenesis - physiology Computer architecture Differentiation (biology) Fractures Gene expression Gene Expression - physiology Genetic markers Health aspects High temperature Humans In vitro methods and tests Mammals Medical research Medicine and Health Sciences Mesenchymal Stromal Cells - metabolism Mesenchymal Stromal Cells - physiology Mesenchyme Mice Mineralization Osteoblasts - metabolism Osteogenesis Osteogenesis - physiology Physiology Protease Proteases Proteinase Proteins Regeneration Regeneration - physiology Research and Analysis Methods Ribonucleic acid RNA Serine Endopeptidases - metabolism Stem cell transplantation Stem cells Stimulation Studies Temperature effects Temperature requirements
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