Impact of diabetes mellitus on indeterminate results of the QuantiFERON TB Gold In-Tube test: A propensity score matching analysis
The sensitivity of interferon-gamma release assays (IGRAs) in the detection of Mycobacterium tuberculosis infection could be affected by conditions of immune dysregulation. For this reason, diabetes mellitus (DM) may increase the frequency of indeterminate results of IGRAs. However, there have been...
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| creator | Shin, Hong-Joon Kim, Tae-Ok Oh, Hyung-Joo Park, Ha-Young Chang, Jin-Sun Ahn, Seong Kim, Yu-Il Lim, Sung-Chul Kwon, Yong-Soo |
| description | The sensitivity of interferon-gamma release assays (IGRAs) in the detection of Mycobacterium tuberculosis infection could be affected by conditions of immune dysregulation. For this reason, diabetes mellitus (DM) may increase the frequency of indeterminate results of IGRAs. However, there have been inconsistent reports of role of DM on indeterminate IGRA results.
We retrospectively reviewed all patients who underwent QuantiFERON-TB Gold In-Tube testing (QFT-GIT) at Chonnam National University Hospital. We collected the clinical and laboratory data of these patients.
Of all 3,391 subjects, 1,265 (37.3%) had a positive QFT-GIT result, 266 (7.8%) had an indeterminate result, and 1,860 (54.9%) had a negative result. The mean age was 54.8 ± 18.1 years and 55.0% of the patients were male. There were 512 (15.1%) patients with DM. Multivariable analysis revealed that systemic corticosteroid use, tuberculosis, lymphocytopenia, low serum albumin, and high serum C-reactive protein (CRP) levels were significantly associated with indeterminate QFT-GIT results. However, DM was not associated with indeterminate QFT-GIT results (adjusted odds ratio, 0.98; 95% confidence interval, 0.69-1.41; P = 0.939). After propensity score matching, DM was not associated with indeterminate results of QFT-GIT.
In this large cohort study, DM does not affect the incidence of indeterminate results of QFT-GIT. |
| doi_str_mv | 10.1371/journal.pone.0181887 |
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We retrospectively reviewed all patients who underwent QuantiFERON-TB Gold In-Tube testing (QFT-GIT) at Chonnam National University Hospital. We collected the clinical and laboratory data of these patients.
Of all 3,391 subjects, 1,265 (37.3%) had a positive QFT-GIT result, 266 (7.8%) had an indeterminate result, and 1,860 (54.9%) had a negative result. The mean age was 54.8 ± 18.1 years and 55.0% of the patients were male. There were 512 (15.1%) patients with DM. Multivariable analysis revealed that systemic corticosteroid use, tuberculosis, lymphocytopenia, low serum albumin, and high serum C-reactive protein (CRP) levels were significantly associated with indeterminate QFT-GIT results. However, DM was not associated with indeterminate QFT-GIT results (adjusted odds ratio, 0.98; 95% confidence interval, 0.69-1.41; P = 0.939). After propensity score matching, DM was not associated with indeterminate results of QFT-GIT.
In this large cohort study, DM does not affect the incidence of indeterminate results of QFT-GIT.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0181887</identifier><identifier>PMID: 28732078</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Age ; Albumin ; Analysis ; Antigens ; Assaying ; Biology and Life Sciences ; C-reactive protein ; C-Reactive Protein - metabolism ; Complications and side effects ; Confidence intervals ; Corticosteroids ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus - metabolism ; Diabetes Mellitus - pathology ; Diagnosis ; Dosage and administration ; Female ; Health aspects ; HIV ; Hospitals, University ; Human immunodeficiency virus ; Humans ; Incidence ; Infections ; Interferon ; Interferon-gamma - metabolism ; Interferon-gamma Release Tests - methods ; Internal medicine ; Laboratories ; Lymphopenia ; Male ; Matching ; Medical diagnosis ; Medical schools ; Medicine ; Medicine and Health Sciences ; Middle Aged ; Mycobacterium tuberculosis - pathogenicity ; Patients ; Propensity Score ; Proteins ; Retrospective Studies ; Sensitivity analysis ; Serum albumin ; Tuberculin Test - methods ; Tuberculosis ; Tuberculosis - diagnosis ; Tuberculosis - metabolism</subject><ispartof>PloS one, 2017-07, Vol.12 (7), p.e0181887-e0181887</ispartof><rights>COPYRIGHT 2017 Public Library of Science</rights><rights>2017 Shin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2017 Shin et al 2017 Shin et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-63d7828a345a654e6fba601e496bb73beba45e46546adcd2de55524fe7503bb33</citedby><cites>FETCH-LOGICAL-c692t-63d7828a345a654e6fba601e496bb73beba45e46546adcd2de55524fe7503bb33</cites><orcidid>0000-0001-5121-4488</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5521843/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5521843/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28732078$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shin, Hong-Joon</creatorcontrib><creatorcontrib>Kim, Tae-Ok</creatorcontrib><creatorcontrib>Oh, Hyung-Joo</creatorcontrib><creatorcontrib>Park, Ha-Young</creatorcontrib><creatorcontrib>Chang, Jin-Sun</creatorcontrib><creatorcontrib>Ahn, Seong</creatorcontrib><creatorcontrib>Kim, Yu-Il</creatorcontrib><creatorcontrib>Lim, Sung-Chul</creatorcontrib><creatorcontrib>Kwon, Yong-Soo</creatorcontrib><title>Impact of diabetes mellitus on indeterminate results of the QuantiFERON TB Gold In-Tube test: A propensity score matching analysis</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The sensitivity of interferon-gamma release assays (IGRAs) in the detection of Mycobacterium tuberculosis infection could be affected by conditions of immune dysregulation. For this reason, diabetes mellitus (DM) may increase the frequency of indeterminate results of IGRAs. However, there have been inconsistent reports of role of DM on indeterminate IGRA results.
We retrospectively reviewed all patients who underwent QuantiFERON-TB Gold In-Tube testing (QFT-GIT) at Chonnam National University Hospital. We collected the clinical and laboratory data of these patients.
Of all 3,391 subjects, 1,265 (37.3%) had a positive QFT-GIT result, 266 (7.8%) had an indeterminate result, and 1,860 (54.9%) had a negative result. The mean age was 54.8 ± 18.1 years and 55.0% of the patients were male. There were 512 (15.1%) patients with DM. Multivariable analysis revealed that systemic corticosteroid use, tuberculosis, lymphocytopenia, low serum albumin, and high serum C-reactive protein (CRP) levels were significantly associated with indeterminate QFT-GIT results. However, DM was not associated with indeterminate QFT-GIT results (adjusted odds ratio, 0.98; 95% confidence interval, 0.69-1.41; P = 0.939). After propensity score matching, DM was not associated with indeterminate results of QFT-GIT.
In this large cohort study, DM does not affect the incidence of indeterminate results of QFT-GIT.</description><subject>Age</subject><subject>Albumin</subject><subject>Analysis</subject><subject>Antigens</subject><subject>Assaying</subject><subject>Biology and Life Sciences</subject><subject>C-reactive protein</subject><subject>C-Reactive Protein - metabolism</subject><subject>Complications and side effects</subject><subject>Confidence intervals</subject><subject>Corticosteroids</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus - metabolism</subject><subject>Diabetes Mellitus - pathology</subject><subject>Diagnosis</subject><subject>Dosage and administration</subject><subject>Female</subject><subject>Health aspects</subject><subject>HIV</subject><subject>Hospitals, University</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Incidence</subject><subject>Infections</subject><subject>Interferon</subject><subject>Interferon-gamma - metabolism</subject><subject>Interferon-gamma Release Tests - methods</subject><subject>Internal medicine</subject><subject>Laboratories</subject><subject>Lymphopenia</subject><subject>Male</subject><subject>Matching</subject><subject>Medical diagnosis</subject><subject>Medical schools</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Mycobacterium tuberculosis - pathogenicity</subject><subject>Patients</subject><subject>Propensity Score</subject><subject>Proteins</subject><subject>Retrospective Studies</subject><subject>Sensitivity analysis</subject><subject>Serum albumin</subject><subject>Tuberculin Test - methods</subject><subject>Tuberculosis</subject><subject>Tuberculosis - diagnosis</subject><subject>Tuberculosis - metabolism</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk1Fv0zAQxyMEYmPwDRBYQkLw0BLHiePwgFSmbVSaqBiFV-viXFpXiV1sB9FXPjku7aYW7QH5Idb5d__7-5xLkuc0HVNW0ncrOzgD3XhtDY5TKqgQ5YPklFYsG_EsZQ8P9ifJE-9XaVowwfnj5CQTJcvSUpwmv6f9GlQgtiWNhhoDetJj1-kweGIN0aaJMddrAwGJQz90wW_psETyZQAT9OXFzewzmX8kV7ZryNSM5kONJAqF92RC1s6u0XgdNsQr65D0ENRSmwWB6H7jtX-aPGqh8_hs_z1Lvl1ezM8_ja5nV9PzyfVI8SoLI86aUmQCWF4AL3LkbQ08pZhXvK5LVmMNeYF5POLQqCZrsCiKLG-xLFJW14ydJS93uuvOerlvn5e0yjJacp7lkZjuiMbCSq6d7sFtpAUt_wasW0hwQasOpapoBcArIbI6b4HWWLKGtYpWbVpSWkatD_tqQ91jo9AEB92R6PGJ0Uu5sD9lNE1FvrX7Zi_g7I8hdlP22qv4NGDQDjvfBY3Wt7Ve_YPef7s9tYB4AW1aG-uqraic5JWoBBOiitT4HiquBnut4r_W6hg_Snh7lBCZgL_CAgbv5fTrzf-zs-_H7OsDdonQhaW33RC0Nf4YzHegctZ7h-1dk2kqt6Ny2w25HRW5H5WY9uLwge6SbmeD_QHHaQ9m</recordid><startdate>20170721</startdate><enddate>20170721</enddate><creator>Shin, Hong-Joon</creator><creator>Kim, Tae-Ok</creator><creator>Oh, Hyung-Joo</creator><creator>Park, Ha-Young</creator><creator>Chang, Jin-Sun</creator><creator>Ahn, Seong</creator><creator>Kim, Yu-Il</creator><creator>Lim, Sung-Chul</creator><creator>Kwon, Yong-Soo</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-5121-4488</orcidid></search><sort><creationdate>20170721</creationdate><title>Impact of diabetes mellitus on indeterminate results of the QuantiFERON TB Gold In-Tube test: A propensity score matching analysis</title><author>Shin, Hong-Joon ; Kim, Tae-Ok ; Oh, Hyung-Joo ; Park, Ha-Young ; Chang, Jin-Sun ; Ahn, Seong ; Kim, Yu-Il ; Lim, Sung-Chul ; Kwon, Yong-Soo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-63d7828a345a654e6fba601e496bb73beba45e46546adcd2de55524fe7503bb33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Age</topic><topic>Albumin</topic><topic>Analysis</topic><topic>Antigens</topic><topic>Assaying</topic><topic>Biology and Life Sciences</topic><topic>C-reactive protein</topic><topic>C-Reactive Protein - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shin, Hong-Joon</au><au>Kim, Tae-Ok</au><au>Oh, Hyung-Joo</au><au>Park, Ha-Young</au><au>Chang, Jin-Sun</au><au>Ahn, Seong</au><au>Kim, Yu-Il</au><au>Lim, Sung-Chul</au><au>Kwon, Yong-Soo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of diabetes mellitus on indeterminate results of the QuantiFERON TB Gold In-Tube test: A propensity score matching analysis</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2017-07-21</date><risdate>2017</risdate><volume>12</volume><issue>7</issue><spage>e0181887</spage><epage>e0181887</epage><pages>e0181887-e0181887</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The sensitivity of interferon-gamma release assays (IGRAs) in the detection of Mycobacterium tuberculosis infection could be affected by conditions of immune dysregulation. For this reason, diabetes mellitus (DM) may increase the frequency of indeterminate results of IGRAs. However, there have been inconsistent reports of role of DM on indeterminate IGRA results.
We retrospectively reviewed all patients who underwent QuantiFERON-TB Gold In-Tube testing (QFT-GIT) at Chonnam National University Hospital. We collected the clinical and laboratory data of these patients.
Of all 3,391 subjects, 1,265 (37.3%) had a positive QFT-GIT result, 266 (7.8%) had an indeterminate result, and 1,860 (54.9%) had a negative result. The mean age was 54.8 ± 18.1 years and 55.0% of the patients were male. There were 512 (15.1%) patients with DM. Multivariable analysis revealed that systemic corticosteroid use, tuberculosis, lymphocytopenia, low serum albumin, and high serum C-reactive protein (CRP) levels were significantly associated with indeterminate QFT-GIT results. However, DM was not associated with indeterminate QFT-GIT results (adjusted odds ratio, 0.98; 95% confidence interval, 0.69-1.41; P = 0.939). After propensity score matching, DM was not associated with indeterminate results of QFT-GIT.
In this large cohort study, DM does not affect the incidence of indeterminate results of QFT-GIT.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>28732078</pmid><doi>10.1371/journal.pone.0181887</doi><tpages>e0181887</tpages><orcidid>https://orcid.org/0000-0001-5121-4488</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2017-07, Vol.12 (7), p.e0181887-e0181887 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1922176624 |
| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Age Albumin Analysis Antigens Assaying Biology and Life Sciences C-reactive protein C-Reactive Protein - metabolism Complications and side effects Confidence intervals Corticosteroids Diabetes Diabetes mellitus Diabetes Mellitus - metabolism Diabetes Mellitus - pathology Diagnosis Dosage and administration Female Health aspects HIV Hospitals, University Human immunodeficiency virus Humans Incidence Infections Interferon Interferon-gamma - metabolism Interferon-gamma Release Tests - methods Internal medicine Laboratories Lymphopenia Male Matching Medical diagnosis Medical schools Medicine Medicine and Health Sciences Middle Aged Mycobacterium tuberculosis - pathogenicity Patients Propensity Score Proteins Retrospective Studies Sensitivity analysis Serum albumin Tuberculin Test - methods Tuberculosis Tuberculosis - diagnosis Tuberculosis - metabolism |
| title | Impact of diabetes mellitus on indeterminate results of the QuantiFERON TB Gold In-Tube test: A propensity score matching analysis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T01%3A41%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Impact%20of%20diabetes%20mellitus%20on%20indeterminate%20results%20of%20the%20QuantiFERON%20TB%20Gold%20In-Tube%20test:%20A%20propensity%20score%20matching%20analysis&rft.jtitle=PloS%20one&rft.au=Shin,%20Hong-Joon&rft.date=2017-07-21&rft.volume=12&rft.issue=7&rft.spage=e0181887&rft.epage=e0181887&rft.pages=e0181887-e0181887&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0181887&rft_dat=%3Cgale_plos_%3EA498983889%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1922176624&rft_id=info:pmid/28732078&rft_galeid=A498983889&rft_doaj_id=oai_doaj_org_article_c919aa69882b4fa1be73d3fc19f07117&rfr_iscdi=true |