Cx47 fine-tunes the handling of serum lipids but is dispensable for lymphatic vascular function

Mutations in the gap junction protein connexin47 (Cx47) are associated with lymphedema. However, the role of Cx47 in lymphatic pathophysiology is unknown. We demonstrate that Cx47 is expressed in lymphatic endothelial cells by whole-mount immunostaining and qPCR. To determine if Cx47 plays a role in...

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Veröffentlicht in:	PloS one 2017-07, Vol.12 (7), p.e0181476-e0181476
Hauptverfasser:	Meens, Merlijn J, Kutkut, Issa, Rochemont, Viviane, Dubrot, Juan, Kaladji, Fouad R, Sabine, Amélie, Lyons, Oliver, Hendrikx, Stefanie, Bernier-Latmani, Jeremiah, Kiefer, Friedemann, Smith, Alberto, Hugues, Stéphanie, Petrova, Tatiana V, Kwak, Brenda R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adults Aging - metabolism Aging - pathology Animals Apolipoprotein E Apolipoproteins E - genetics Apolipoproteins E - metabolism Arteriosclerosis Atherosclerosis Atherosclerosis - metabolism Atherosclerosis - pathology Biology and Life Sciences Blood vessels Care and treatment Cell Movement - physiology Cholesterol Cholesterol, LDL - blood Collagen Collagen - metabolism Connexins - genetics Connexins - metabolism Contractility Dendritic cells Dendritic Cells - metabolism Dendritic Cells - pathology Diet, High-Fat Digestive tract Disease Models, Animal Endothelial cells Endothelial Cells - metabolism Endothelial Cells - pathology Endothelium Fatty acids Fatty Acids - metabolism Gastrointestinal tract Gene mutation Immunological tolerance Leukocyte migration Lipids Low density lipoprotein Lymphatic system Lymphatic Vessels - metabolism Lymphatic Vessels - pathology Lymphedema Lymphocytes Lymphocytes T Macrophages Macrophages - metabolism Macrophages - pathology Medicine and Health Sciences Mice Mice, Inbred C57BL Mice, Knockout Mutation Pathology Plaques Rodents Serum lipids T-Lymphocytes - metabolism T-Lymphocytes - pathology Thorax Triglycerides - blood Wound drainage
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