Dysfunctional GPR40/FFAR1 signaling exacerbates pain behavior in mice

We previously showed that activation of G protein-coupled receptor 40/free fatty acid receptor 1 (GPR40/FFAR1) signaling modulates descending inhibition of pain. In this study, we investigated the involvement of fatty acid-GPR40/FFAR1 signaling in the transition from acute to chronic pain. We used G...

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Veröffentlicht in:	PloS one 2017-07, Vol.12 (7), p.e0180610-e0180610
Hauptverfasser:	Nakamoto, Kazuo, Aizawa, Fuka, Miyagi, Kei, Yamashita, Takuya, Mankura, Mitsumasa, Koyama, Yutaka, Kasuya, Fumiyo, Hirasawa, Akira, Kurihara, Takashi, Miyata, Atsuro, Tokuyama, Shogo
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Behavior, Animal - drug effects Behavior, Animal - physiology Benzoates - pharmacology Biology and Life Sciences Chromatography Chronic pain Control Docosahexaenoic acid Docosahexaenoic Acids - metabolism Endorphins Extracellular signal-regulated kinase Fatty acids Health aspects Hyperalgesia Hyperalgesia - genetics Hyperalgesia - metabolism Hypothalamus Hypothalamus - metabolism Immunohistochemistry Inhibition Liquid chromatography Mass spectrometry Mass spectroscopy Medicine and Health Sciences Mice Mice, Knockout Narcotics Neurons Oleic acid Oleic Acid - metabolism Pain Pain Measurement Pain perception Palmitic acid Palmitic Acid - metabolism Pharmaceutical sciences Pharmaceuticals Pharmacology Pharmacy Phosphorylation Pyrimidines - pharmacology Receptors, G-Protein-Coupled - agonists Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism Signal transduction Signal Transduction - drug effects Signal Transduction - physiology Spinal cord Stem cells Stimulation Studies Surgery Toxicology
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