The human cytomegalovirus glycoprotein pUL11 acts via CD45 to induce T cell IL-10 secretion

Human Cytomegalovirus (HCMV) is a widespread pathogen, infection with which can cause severe disease for immunocompromised individuals. The complex changes wrought on the host's immune system during both productive and latent HCMV infection are well known. Infected cells are masked and manipula...

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Veröffentlicht in:	PLoS pathogens 2017-06, Vol.13 (6), p.e1006454-e1006454
Hauptverfasser:	Zischke, Jasmin, Mamareli, Panagiota, Pokoyski, Claudia, Gabaev, Ildar, Buyny, Sabine, Jacobs, Roland, Falk, Christine S, Lochner, Matthias, Sparwasser, Tim, Schulz, Thomas F, Kay-Fedorov, Penelope C
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-inflammatory agents Antigens Biology and Life Sciences CD4-Positive T-Lymphocytes - metabolism CD45 antigen Cell proliferation Cells, Cultured Collaboration Cytokines Cytomegalovirus Cytomegalovirus - genetics Cytomegalovirus - metabolism Cytomegalovirus Infections - genetics Cytomegalovirus Infections - metabolism Cytomegalovirus Infections - virology Funding Genomes Glycoproteins Glycoproteins - genetics Glycoproteins - metabolism Humans Immune system Immunology Infections Inflammation Interleukin 10 Interleukin-10 - genetics Interleukin-10 - metabolism Joint ventures Kinases Lck protein Leukocyte Common Antigens - genetics Leukocyte Common Antigens - metabolism Leukocytes, Mononuclear - metabolism Lymphocytes Lymphocytes T Medical schools Medicine and Health Sciences Mutation Pathogens Peripheral blood mononuclear cells Phosphatase Proteins Research and Analysis Methods Rheumatology Signal strength Signaling Supervision T cell receptors T cells T-cell receptor Transcription factors Transplants & implants Viral Proteins - genetics Viral Proteins - metabolism Virology
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