Genome-scale analysis of the genes that contribute to Burkholderia pseudomallei biofilm formation identifies a crucial exopolysaccharide biosynthesis gene cluster

Burkholderia pseudomallei, the causative agent of melioidosis, is an important public health threat due to limited therapeutic options for treatment. Efforts to improve therapeutics for B. pseudomallei infections are dependent on the need to understand the role of B. pseudomallei biofilm formation a...

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Veröffentlicht in:	PLoS neglected tropical diseases 2017-06, Vol.11 (6), p.e0005689
Hauptverfasser:	Borlee, Grace I, Plumley, Brooke A, Martin, Kevin H, Somprasong, Nawarat, Mangalea, Mihnea R, Islam, M Nurul, Burtnick, Mary N, Brett, Paul J, Steinmetz, Ivo, AuCoin, David P, Belisle, John T, Crick, Dean C, Schweizer, Herbert P, Borlee, Bradley R
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotic tolerance Bacteria Biofilms Biofilms - growth & development Bioinformatics Biology and Life Sciences Biosynthesis Burkholderia cenocepacia - genetics Burkholderia pseudomallei Burkholderia pseudomallei - genetics Burkholderia pseudomallei - physiology Colonization Comparative Genomic Hybridization Deletion mutant Flagella Gene deletion Gene Expression Regulation, Bacterial Genetic aspects Genome, Bacterial Genomes Health risks Infections Insertion Melioidosis Microbial mats Multigene Family Mutation Pathogens Physiological aspects Pili Polysaccharides Polysaccharides, Bacterial - genetics Public health Research and Analysis Methods Saccharides Transcription Tropical diseases
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