Impact of stage, management and recurrence on survival rates in laryngeal cancer
A retrospective, longitudinal study of 1,616 patients with primary laryngeal squamous cell carcinoma (LSCC) at a single center in Norway during 1983-2010 was undertaken to investigate overall survival, disease specific survival, disease-free survival, prognostic factors for overall survival, and imp...
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| description | A retrospective, longitudinal study of 1,616 patients with primary laryngeal squamous cell carcinoma (LSCC) at a single center in Norway during 1983-2010 was undertaken to investigate overall survival, disease specific survival, disease-free survival, prognostic factors for overall survival, and impact of recurrence among all-stage laryngeal cancer patients over 15 years' follow-up. The prognostic impact of gender, age, smoking/alcohol, subsite, tumour, node and metastasis staging, period and modality of treatment were evaluated using Kaplan-Meier and Cox proportional hazard analyses. The importance of recurrence on survival was assessed based on case fatality rates. Five-year overall survival was 56.8%, 64.0% and 38.8%, and disease-specific survival was 80.2%, 87% and 61.6%, respectively, for the entire cohort and for glottic and supraglottic LSCC. Old age, advanced-stage LSCC and supraglottic cancer were associated with lower overall survival. The risk of disease-specific death plateaued after five years and varied significantly by subsite. Multivariate analysis of glottic LSCC revealed that surgical treatment improved overall survival, whereas old age, alcohol, T3-T4 status, positive N-status and no treatment were associated with worse survival. In supraglottic LSCC, age, alcohol, and positive N-status had a significant impact on overall survival by multivariate analysis. Five-year overall survival and disease-specific survival among patients with recurrent disease were 34% and 52%, respectively. In conclusion, marked difference in overall survival between glottic and supraglottic LSCC underline the importance of subsite-specific survival analysis. T-status and primary surgical management is essential only for glottic LSCC, emphasizing the importance of correct disease classification. Inferior outcomes in supraglottic LSCC are associated with old age, positive N-status, and improved follow-up routines are necessary. Primary tumor control is essential since recurrence impairs survival considerably in all subsites. The potential benefit of a primary surgical approach towards T3 LSCC awaits further investigation. |
| doi_str_mv | 10.1371/journal.pone.0179371 |
| format | Article |
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The prognostic impact of gender, age, smoking/alcohol, subsite, tumour, node and metastasis staging, period and modality of treatment were evaluated using Kaplan-Meier and Cox proportional hazard analyses. The importance of recurrence on survival was assessed based on case fatality rates. Five-year overall survival was 56.8%, 64.0% and 38.8%, and disease-specific survival was 80.2%, 87% and 61.6%, respectively, for the entire cohort and for glottic and supraglottic LSCC. Old age, advanced-stage LSCC and supraglottic cancer were associated with lower overall survival. The risk of disease-specific death plateaued after five years and varied significantly by subsite. Multivariate analysis of glottic LSCC revealed that surgical treatment improved overall survival, whereas old age, alcohol, T3-T4 status, positive N-status and no treatment were associated with worse survival. In supraglottic LSCC, age, alcohol, and positive N-status had a significant impact on overall survival by multivariate analysis. Five-year overall survival and disease-specific survival among patients with recurrent disease were 34% and 52%, respectively. In conclusion, marked difference in overall survival between glottic and supraglottic LSCC underline the importance of subsite-specific survival analysis. T-status and primary surgical management is essential only for glottic LSCC, emphasizing the importance of correct disease classification. Inferior outcomes in supraglottic LSCC are associated with old age, positive N-status, and improved follow-up routines are necessary. Primary tumor control is essential since recurrence impairs survival considerably in all subsites. The potential benefit of a primary surgical approach towards T3 LSCC awaits further investigation.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0179371</identifier><identifier>PMID: 28708883</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Age ; Aged ; Alcohol Drinking ; Alcoholic beverages ; Cancer ; Cancer recurrence ; Cancer staging ; Cancer therapies ; Carcinoma, Squamous Cell - mortality ; Carcinoma, Squamous Cell - pathology ; Care and treatment ; Classification ; Clinical medicine ; Correlation analysis ; Disease-Free Survival ; Female ; Geriatrics ; Glottis - pathology ; Head and Neck Neoplasms - mortality ; Head and Neck Neoplasms - pathology ; Health risks ; Hospitals ; Humans ; Kaplan-Meier Estimate ; Laryngeal cancer ; Laryngeal Neoplasms - mortality ; Laryngeal Neoplasms - pathology ; Larynx ; Lasers ; Longitudinal Studies ; Male ; Medical prognosis ; Medicine ; Medicine and Health Sciences ; Metastases ; Microsurgery ; Middle Aged ; Mortality ; Multivariate analysis ; Neck ; Neoplasm Recurrence, Local ; Neoplasm Staging ; Neurosciences ; Otolaryngology ; Patient outcomes ; Patients ; Physical Sciences ; Prognosis ; Proportional Hazards Models ; Radiation therapy ; Research and Analysis Methods ; Retrospective Studies ; Risk assessment ; Risk Factors ; Routines ; Smoking ; Squamous cell carcinoma ; Squamous Cell Carcinoma of Head and Neck ; Studies ; Surgeons ; Surgery ; Survival ; Survival analysis ; Tumors</subject><ispartof>PloS one, 2017-07, Vol.12 (7), p.e0179371-e0179371</ispartof><rights>COPYRIGHT 2017 Public Library of Science</rights><rights>2017 Brandstorp-Boesen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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The potential benefit of a primary surgical approach towards T3 LSCC awaits further investigation.</description><subject>Age</subject><subject>Aged</subject><subject>Alcohol Drinking</subject><subject>Alcoholic beverages</subject><subject>Cancer</subject><subject>Cancer recurrence</subject><subject>Cancer staging</subject><subject>Cancer therapies</subject><subject>Carcinoma, Squamous Cell - mortality</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Care and treatment</subject><subject>Classification</subject><subject>Clinical medicine</subject><subject>Correlation analysis</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Geriatrics</subject><subject>Glottis - pathology</subject><subject>Head and Neck Neoplasms - mortality</subject><subject>Head and Neck Neoplasms - pathology</subject><subject>Health risks</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Kaplan-Meier Estimate</subject><subject>Laryngeal cancer</subject><subject>Laryngeal Neoplasms - mortality</subject><subject>Laryngeal Neoplasms - pathology</subject><subject>Larynx</subject><subject>Lasers</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Metastases</subject><subject>Microsurgery</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Multivariate analysis</subject><subject>Neck</subject><subject>Neoplasm Recurrence, Local</subject><subject>Neoplasm Staging</subject><subject>Neurosciences</subject><subject>Otolaryngology</subject><subject>Patient outcomes</subject><subject>Patients</subject><subject>Physical Sciences</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Radiation therapy</subject><subject>Research and Analysis Methods</subject><subject>Retrospective Studies</subject><subject>Risk 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One</addtitle><date>2017-07-14</date><risdate>2017</risdate><volume>12</volume><issue>7</issue><spage>e0179371</spage><epage>e0179371</epage><pages>e0179371-e0179371</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>A retrospective, longitudinal study of 1,616 patients with primary laryngeal squamous cell carcinoma (LSCC) at a single center in Norway during 1983-2010 was undertaken to investigate overall survival, disease specific survival, disease-free survival, prognostic factors for overall survival, and impact of recurrence among all-stage laryngeal cancer patients over 15 years' follow-up. The prognostic impact of gender, age, smoking/alcohol, subsite, tumour, node and metastasis staging, period and modality of treatment were evaluated using Kaplan-Meier and Cox proportional hazard analyses. The importance of recurrence on survival was assessed based on case fatality rates. Five-year overall survival was 56.8%, 64.0% and 38.8%, and disease-specific survival was 80.2%, 87% and 61.6%, respectively, for the entire cohort and for glottic and supraglottic LSCC. Old age, advanced-stage LSCC and supraglottic cancer were associated with lower overall survival. The risk of disease-specific death plateaued after five years and varied significantly by subsite. Multivariate analysis of glottic LSCC revealed that surgical treatment improved overall survival, whereas old age, alcohol, T3-T4 status, positive N-status and no treatment were associated with worse survival. In supraglottic LSCC, age, alcohol, and positive N-status had a significant impact on overall survival by multivariate analysis. Five-year overall survival and disease-specific survival among patients with recurrent disease were 34% and 52%, respectively. In conclusion, marked difference in overall survival between glottic and supraglottic LSCC underline the importance of subsite-specific survival analysis. T-status and primary surgical management is essential only for glottic LSCC, emphasizing the importance of correct disease classification. Inferior outcomes in supraglottic LSCC are associated with old age, positive N-status, and improved follow-up routines are necessary. Primary tumor control is essential since recurrence impairs survival considerably in all subsites. The potential benefit of a primary surgical approach towards T3 LSCC awaits further investigation.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>28708883</pmid><doi>10.1371/journal.pone.0179371</doi><tpages>e0179371</tpages><orcidid>https://orcid.org/0000-0003-2709-9912</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2017-07, Vol.12 (7), p.e0179371-e0179371 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1919505332 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Age Aged Alcohol Drinking Alcoholic beverages Cancer Cancer recurrence Cancer staging Cancer therapies Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - pathology Care and treatment Classification Clinical medicine Correlation analysis Disease-Free Survival Female Geriatrics Glottis - pathology Head and Neck Neoplasms - mortality Head and Neck Neoplasms - pathology Health risks Hospitals Humans Kaplan-Meier Estimate Laryngeal cancer Laryngeal Neoplasms - mortality Laryngeal Neoplasms - pathology Larynx Lasers Longitudinal Studies Male Medical prognosis Medicine Medicine and Health Sciences Metastases Microsurgery Middle Aged Mortality Multivariate analysis Neck Neoplasm Recurrence, Local Neoplasm Staging Neurosciences Otolaryngology Patient outcomes Patients Physical Sciences Prognosis Proportional Hazards Models Radiation therapy Research and Analysis Methods Retrospective Studies Risk assessment Risk Factors Routines Smoking Squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck Studies Surgeons Surgery Survival Survival analysis Tumors |
| title | Impact of stage, management and recurrence on survival rates in laryngeal cancer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T21%3A30%3A47IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Impact%20of%20stage,%20management%20and%20recurrence%20on%20survival%20rates%20in%20laryngeal%20cancer&rft.jtitle=PloS%20one&rft.au=Brandstorp-Boesen,%20Jesper&rft.date=2017-07-14&rft.volume=12&rft.issue=7&rft.spage=e0179371&rft.epage=e0179371&rft.pages=e0179371-e0179371&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0179371&rft_dat=%3Cgale_plos_%3EA498539543%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1919505332&rft_id=info:pmid/28708883&rft_galeid=A498539543&rft_doaj_id=oai_doaj_org_article_096cf47b36504b7e89175e900532f5ce&rfr_iscdi=true |