Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program

The International Knockout Mouse Consortium was formed in 2007 to inactivate ("knockout") all protein-coding genes in the mouse genome in embryonic stem cells. Production and characterization of these mice, now underway, has generated and phenotyped 3,100 strains with knockout alleles. Ski...

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Veröffentlicht in:	PloS one 2017-07, Vol.12 (7), p.e0180682-e0180682
Hauptverfasser:	Sundberg, John P, Dadras, Soheil S, Silva, Kathleen A, Kennedy, Victoria E, Garland, Gaven, Murray, Stephen A, Sundberg, Beth A, Schofield, Paul N, Pratt, C Herbert
Format:	Artikel
Sprache:	eng
Schlagworte:	Abdomen Abnormalities Animal models Animals Biology and Life Sciences Consortia Dystrophy Embryo cells Genomes Genomics Glands Hair Hair - abnormalities Histopathology Laboratories Lesions Limbs Low frequencies Medical screening Medicine and Health Sciences Mice Mice, Inbred C57BL Mice, Knockout Mutation Nails (Anatomy) Nails, Malformed - genetics Research and Analysis Methods Reviews Rodents Sebaceous gland Sebaceous glands Sebaceous Glands - pathology Skin - pathology Skin Abnormalities - genetics Skin diseases Social Sciences Stem cell transplantation Stem cells Vibrissae Vibrissae - pathology
Online-Zugang:	Volltext
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