Inflammation dependent mTORC1 signaling interferes with the switch from keratinocyte proliferation to differentiation

Psoriasis is a frequent and often severe inflammatory skin disease, characterized by altered epidermal homeostasis. Since we found previously that Akt/mTOR signaling is hyperactivated in psoriatic skin, we aimed at elucidating the role of aberrant mTORC1 signaling in this disease. We found that unde...

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Veröffentlicht in:	PloS one 2017-07, Vol.12 (7), p.e0180853-e0180853
Hauptverfasser:	Buerger, Claudia, Shirsath, Nitesh, Lang, Victoria, Berard, Alina, Diehl, Sandra, Kaufmann, Roland, Boehncke, Wolf-Henning, Wolf, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Aberration Activation Adolescent Adult Aged AKT protein Animals Biology and Life Sciences Cell Differentiation - genetics Cell Differentiation - physiology Cell Line Cell Proliferation - genetics Cell Proliferation - physiology Collagen Cytokines Dermatology Differentiation Female Gene expression Homeostasis Humans Immunoassay Immunohistochemistry Interleukin 1 Keratin Keratinocytes Keratinocytes - metabolism Keratinocytes - physiology Kinases Male Markers Mechanistic Target of Rapamycin Complex 1 Medicine and Health Sciences Mice Mice, Inbred BALB C Middle Aged Multiprotein Complexes - genetics Multiprotein Complexes - metabolism Pathogenesis Phosphorylation Proteins Psoriasis Research and Analysis Methods Reverse Transcriptase Polymerase Chain Reaction RNA, Small Interfering - genetics Signal Transduction - genetics Signal Transduction - physiology Skin diseases TOR protein TOR Serine-Threonine Kinases - genetics TOR Serine-Threonine Kinases - metabolism Tumor necrosis factor Young Adult
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