Cancer-selective, single agent chemoradiosensitising gold nanoparticles
Two nanometre gold nanoparticles (AuNPs), bearing sugar moieties and/or thiol-polyethylene glycol-amine (PEG-amine), were synthesised and evaluated for their in vitro toxicity and ability to radiosensitise cells with 220 kV and 6 MV X-rays, using four cell lines representing normal and cancerous ski...
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| Veröffentlicht in: | PloS one 2017-07, Vol.12 (7), p.e0181103 |
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| creator | Grellet, Sophie Tzelepi, Konstantina Roskamp, Meike Williams, Phil Sharif, Aquila Slade-Carter, Richard Goldie, Peter Whilde, Nicky Śmiałek, Małgorzata A Mason, Nigel J Golding, Jon P |
| description | Two nanometre gold nanoparticles (AuNPs), bearing sugar moieties and/or thiol-polyethylene glycol-amine (PEG-amine), were synthesised and evaluated for their in vitro toxicity and ability to radiosensitise cells with 220 kV and 6 MV X-rays, using four cell lines representing normal and cancerous skin and breast tissues. Acute 3 h exposure of cells to AuNPs, bearing PEG-amine only or a 50:50 ratio of alpha-galactose derivative and PEG-amine resulted in selective uptake and toxicity towards cancer cells at unprecedentedly low nanomolar concentrations. Chemotoxicity was prevented by co-administration of N-acetyl cysteine antioxidant, or partially prevented by the caspase inhibitor Z-VAD-FMK. In addition to their intrinsic cancer-selective chemotoxicity, these AuNPs acted as radiosensitisers in combination with 220 kV or 6 MV X-rays. The ability of AuNPs bearing simple ligands to act as cancer-selective chemoradiosensitisers at low concentrations is a novel discovery that holds great promise in developing low-cost cancer nanotherapeutics. |
| doi_str_mv | 10.1371/journal.pone.0181103 |
| format | Article |
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Acute 3 h exposure of cells to AuNPs, bearing PEG-amine only or a 50:50 ratio of alpha-galactose derivative and PEG-amine resulted in selective uptake and toxicity towards cancer cells at unprecedentedly low nanomolar concentrations. Chemotoxicity was prevented by co-administration of N-acetyl cysteine antioxidant, or partially prevented by the caspase inhibitor Z-VAD-FMK. In addition to their intrinsic cancer-selective chemotoxicity, these AuNPs acted as radiosensitisers in combination with 220 kV or 6 MV X-rays. The ability of AuNPs bearing simple ligands to act as cancer-selective chemoradiosensitisers at low concentrations is a novel discovery that holds great promise in developing low-cost cancer nanotherapeutics.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0181103</identifier><identifier>PMID: 28700660</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Apoptosis ; Apoptosis - drug effects ; Bearing ; Biocompatibility ; Biology and Life Sciences ; Biomedical materials ; Biotechnology ; Breast cancer ; Cancer ; Cancer therapies ; Caspase ; Caspase Inhibitors - chemistry ; Caspase Inhibitors - pharmacology ; Cell Line ; Cell Line, Tumor ; Cysteine ; Cytotoxicity ; Engineering and Technology ; Galactose ; Gold ; Gold - chemistry ; Humans ; In vitro methods and tests ; Inhibitors ; Ionizing radiation ; Ligands ; Low concentrations ; Magnetic Resonance Spectroscopy ; Medicine and Health Sciences ; Metal Nanoparticles - chemistry ; Microscopy, Electron, Transmission ; Nanoparticles ; Nanotechnology ; Physical Sciences ; Polyethylene glycol ; Polyethylenes ; Publishing ; Radiation therapy ; Research and Analysis Methods ; Skin ; Sugar ; Tissues ; Toxicity ; X rays</subject><ispartof>PloS one, 2017-07, Vol.12 (7), p.e0181103</ispartof><rights>2017 Grellet et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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Acute 3 h exposure of cells to AuNPs, bearing PEG-amine only or a 50:50 ratio of alpha-galactose derivative and PEG-amine resulted in selective uptake and toxicity towards cancer cells at unprecedentedly low nanomolar concentrations. Chemotoxicity was prevented by co-administration of N-acetyl cysteine antioxidant, or partially prevented by the caspase inhibitor Z-VAD-FMK. In addition to their intrinsic cancer-selective chemotoxicity, these AuNPs acted as radiosensitisers in combination with 220 kV or 6 MV X-rays. The ability of AuNPs bearing simple ligands to act as cancer-selective chemoradiosensitisers at low concentrations is a novel discovery that holds great promise in developing low-cost cancer nanotherapeutics.</description><subject>Apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Bearing</subject><subject>Biocompatibility</subject><subject>Biology and Life Sciences</subject><subject>Biomedical materials</subject><subject>Biotechnology</subject><subject>Breast cancer</subject><subject>Cancer</subject><subject>Cancer therapies</subject><subject>Caspase</subject><subject>Caspase Inhibitors - chemistry</subject><subject>Caspase Inhibitors - pharmacology</subject><subject>Cell Line</subject><subject>Cell Line, Tumor</subject><subject>Cysteine</subject><subject>Cytotoxicity</subject><subject>Engineering and Technology</subject><subject>Galactose</subject><subject>Gold</subject><subject>Gold - chemistry</subject><subject>Humans</subject><subject>In vitro methods and tests</subject><subject>Inhibitors</subject><subject>Ionizing radiation</subject><subject>Ligands</subject><subject>Low concentrations</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Medicine and Health Sciences</subject><subject>Metal Nanoparticles - 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| subjects | Apoptosis Apoptosis - drug effects Bearing Biocompatibility Biology and Life Sciences Biomedical materials Biotechnology Breast cancer Cancer Cancer therapies Caspase Caspase Inhibitors - chemistry Caspase Inhibitors - pharmacology Cell Line Cell Line, Tumor Cysteine Cytotoxicity Engineering and Technology Galactose Gold Gold - chemistry Humans In vitro methods and tests Inhibitors Ionizing radiation Ligands Low concentrations Magnetic Resonance Spectroscopy Medicine and Health Sciences Metal Nanoparticles - chemistry Microscopy, Electron, Transmission Nanoparticles Nanotechnology Physical Sciences Polyethylene glycol Polyethylenes Publishing Radiation therapy Research and Analysis Methods Skin Sugar Tissues Toxicity X rays |
| title | Cancer-selective, single agent chemoradiosensitising gold nanoparticles |
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