Molecular interactions of EphA4, growth hormone receptor, Janus kinase 2, and signal transducer and activator of transcription 5B

We previously reported that EphA4, a member of the Eph family of receptor tyrosine kinases, is an important modulator of growth hormone (GH) signaling, leading to augmented synthesis of insulin-like growth factor 1 (IGF1) for postnatal body growth. In the present study, we report the molecular inter...

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Veröffentlicht in:	PloS one 2017-07, Vol.12 (7), p.e0180785-e0180785
Hauptverfasser:	Sawada, Takahiro, Arai, Daiki, Jing, Xuefeng, Miyajima, Masayasu, Frank, Stuart J, Sakaguchi, Kazushige
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Amino Acid Sequence Animals Binding Sites Biology Biology and Life Sciences Cell adhesion & migration Cell Line Cellular signal transduction Cloning Deoxyribonucleic acid DNA Endocrinology EphA4 protein Ephrins Fibroblasts Fibroblasts - cytology Fibroblasts - metabolism Gene expression Gene Expression Regulation Growth factors Growth hormone Growth hormones HEK293 Cells Humans Insulin Insulin-like growth factor I Insulin-Like Growth Factor I - genetics Insulin-Like Growth Factor I - metabolism Janus kinase Janus kinase 2 Janus Kinase 2 - genetics Janus Kinase 2 - metabolism Kinases Laboratory animals Ligands Medicine Metabolism Methods Mice Molecular interactions Molecular modelling Nuclear transport Phosphorylation Phosphotransferases Protein Binding Protein Domains Proteins Receptor, EphA4 - genetics Receptor, EphA4 - metabolism Receptors, Somatotropin - genetics Receptors, Somatotropin - metabolism Research and Analysis Methods Rodents Signal Transduction Somatotropin STAT5 Transcription Factor - genetics STAT5 Transcription Factor - metabolism Transcription Transcription (Genetics) Translocation Trends Tyrosine
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