STAT3 balances myocyte hypertrophy vis-à-vis autophagy in response to Angiotensin II by modulating the AMPKα/mTOR axis

Signal transducers and activators of transcription 3 (STAT3) is known to participate in various cardiovascular signal transduction pathways, including those responsible for cardiac hypertrophy and cytoprotection. However, the role of STAT3 signaling in cardiomyocyte autophagy remains unclear. We tes...

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Veröffentlicht in:	PloS one 2017-07, Vol.12 (7), p.e0179835
Hauptverfasser:	Chen, Lei, Zhao, Lin, Samanta, Anweshan, Mahmoudi, Seyed Morteza, Buehler, Tanner, Cantilena, Amy, Vincent, Robert J, Girgis, Magdy, Breeden, Joshua, Asante, Samuel, Xuan, Yu-Ting, Dawn, Buddhadeb
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Adenosine diphosphate Adenosine Diphosphate - metabolism Adenosine Triphosphate - metabolism Alzheimer's disease Alzheimers disease AMP-Activated Protein Kinases - biosynthesis AMP-Activated Protein Kinases - genetics Angiotensin Angiotensin II Angiotensin II - administration & dosage Angiotensin II - genetics Animals ATP Attenuation Autophagy Autophagy - drug effects Autophagy - genetics Biology and Life Sciences Blood pressure Cardiomyocytes Cell death Disease Models, Animal Energy balance Fatty acids Gene expression Gene Expression Regulation - drug effects Gene Knockdown Techniques Heart attacks Heart diseases Heart failure Homeostasis Humans Hypertrophy Hypertrophy - genetics Hypertrophy - metabolism Hypertrophy - pathology Inhibition Kinases Major histocompatibility complex Medicine and Health Sciences Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Pathways Peptides Phagocytosis Pharmacology Protein synthesis Proteins Pyridines Rats Research and Analysis Methods Rodents Scholarships & fellowships Signal Transduction Stat3 protein STAT3 Transcription Factor - antagonists & inhibitors STAT3 Transcription Factor - biosynthesis STAT3 Transcription Factor - genetics Stimulation TOR protein TOR Serine-Threonine Kinases - biosynthesis TOR Serine-Threonine Kinases - genetics Transcription factors Transducers Tyrphostins
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