Cytomegalovirus infection in HIV-infected and uninfected individuals is characterized by circulating regulatory T cells of unconstrained antigenic specificity

Cytomegalovirus (CMV) infection is associated with immune-suppression in immune-compromised hosts and old adults. We previously showed that ex vivo CMV restimulation of peripheral blood mononuclear cells (PBMC) of CMV-seropositive volunteers expanded CD4+CD27-CD28- regulatory T cells (Tregs). Here w...

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Veröffentlicht in:	PloS one 2017-07, Vol.12 (7), p.e0180691-e0180691
Hauptverfasser:	Tovar-Salazar, Adriana, Weinberg, Adriana
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome Adult Adults AIDS Antigens Antigens, CD - immunology B cells Biology and Life Sciences CD147 antigen CD27 antigen CD28 antigen CD3 antigen CD4 antigen CD8 antigen Cell proliferation Cells (biology) Cloning Comparative analysis Cytomegalovirus Cytomegalovirus infections Cytomegalovirus Infections - immunology Disease susceptibility Effector cells Foxp3 protein Granzyme B HIV HIV infections HIV Infections - complications HIV Infections - immunology HIV patients Human immunodeficiency virus Humans Immune response (cell-mediated) Immune system Immunophenotyping Immunoregulation Infection Infections Influenza Leukocytes (mononuclear) Lymphocytes Lymphocytes T Medicine and Health Sciences Older people Peripheral blood mononuclear cells Similarity Stem cells Stimulation Studies T cell receptors T cells T-Lymphocytes, Regulatory - immunology Transforming growth factors Varicella Viral infections Viruses
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