Physical activity domains and risk of gastric adenocarcinoma in the MCC-Spain case-control study
Evidence for a protective role of physical activity against development of stomach cancer is yet inconclusive. We studied the association of domain-specific physical activity and the risk of gastric adenocarcinoma (GAC), by site and histology, in the MCC-Spain case-control study. 428 histologically...
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| Veröffentlicht in: | PloS one 2017-07, Vol.12 (7), p.e0179731-e0179731 |
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| creator | Huerta, José M Chirlaque, María Dolores Molina, Antonio J Amiano, Pilar Martín, Vicente Fernández-Villa, Tania Pérez-Gómez, Beatriz Moreno, Víctor Burgui, Rosana Gómez-Acebo, Inés Ramos-Lora, Manuel Fernández-Tardón, Guillermo Peiró, Rosana Olmedo-Requena, Rocío Pollán, Marina Kogevinas, Manolis Castaño-Vinyals, Gemma Aragonés, Nuria |
| description | Evidence for a protective role of physical activity against development of stomach cancer is yet inconclusive. We studied the association of domain-specific physical activity and the risk of gastric adenocarcinoma (GAC), by site and histology, in the MCC-Spain case-control study.
428 histologically confirmed GAC cases (67% men) including the gastro-esophageal region and 3225 controls were included. Cases were recruited in hospitals from 10 different Spanish regions, whereas population controls were randomly selected within the respective hospitals' catchment areas. A physical activity (PA) questionnaire was used to gather information on household and recreational activities, allowing estimation of PA volume (in metabolic equivalents (MET)-min/week). Participants also reported the intensity of working PA and daily sitting time. Questionnaire data on diet, lifestyles and clinical variables including Helicobacter pylori serology were available. Adjusted odds ratios (OR) of GAC were estimated for domains of physical activity, stratifying by sex, site (cardia vs. non-cardia), and Lauren classification (intestinal vs. diffuse).
Household physical activity (HPA) showed a strong inverse association with GAC, observed for both cardia and non-cardia tumours. Risk of overall gastric cancer was 50% lower risk among participants in the highest HPA category (OR = 0.50, 95%CI: 0.38, 0.66). Recreational physical activity (RPA) was also associated with lower overall GAC risk (OR = 0.68, 95% CI: 0.52, 0.88), particularly at moderate levels of intensity such as walking (OR = 0.61, 95% CI: 0.46, 0.79). The protective effect of RPA was strongest for non-cardia tumours. Sedentary time was not related to GAC risk (p-trend = 0.392), but the potential protective effect of RPA was restricted to non-sedentary participants.
Both household and recreational physical activities were independently related to lower GAC risk in the MCC-Spain study. |
| doi_str_mv | 10.1371/journal.pone.0179731 |
| format | Article |
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428 histologically confirmed GAC cases (67% men) including the gastro-esophageal region and 3225 controls were included. Cases were recruited in hospitals from 10 different Spanish regions, whereas population controls were randomly selected within the respective hospitals' catchment areas. A physical activity (PA) questionnaire was used to gather information on household and recreational activities, allowing estimation of PA volume (in metabolic equivalents (MET)-min/week). Participants also reported the intensity of working PA and daily sitting time. Questionnaire data on diet, lifestyles and clinical variables including Helicobacter pylori serology were available. Adjusted odds ratios (OR) of GAC were estimated for domains of physical activity, stratifying by sex, site (cardia vs. non-cardia), and Lauren classification (intestinal vs. diffuse).
Household physical activity (HPA) showed a strong inverse association with GAC, observed for both cardia and non-cardia tumours. Risk of overall gastric cancer was 50% lower risk among participants in the highest HPA category (OR = 0.50, 95%CI: 0.38, 0.66). Recreational physical activity (RPA) was also associated with lower overall GAC risk (OR = 0.68, 95% CI: 0.52, 0.88), particularly at moderate levels of intensity such as walking (OR = 0.61, 95% CI: 0.46, 0.79). The protective effect of RPA was strongest for non-cardia tumours. Sedentary time was not related to GAC risk (p-trend = 0.392), but the potential protective effect of RPA was restricted to non-sedentary participants.
Both household and recreational physical activities were independently related to lower GAC risk in the MCC-Spain study.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0179731</identifier><identifier>PMID: 28683070</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adenocarcinoma ; Adenocarcinoma - diagnosis ; Adenocarcinoma - pathology ; Adenocarcinoma - prevention & control ; Aged ; Aged, 80 and over ; Alcohol use ; Biology and Life Sciences ; Cancer ; Cancer research ; Case studies ; Case-Control Studies ; Catchment areas ; Classification ; Control methods ; Càncer ; Disease prevention ; Epidemiology ; Esophagus ; Estómac ; Exercici ; Exercise ; Female ; Gastric cancer ; Health aspects ; Health risk assessment ; Health risks ; Helicobacter pylori ; Histology ; Hospitals ; Humans ; Intestine ; Male ; Medicine and Health Sciences ; Men ; Metabolic Equivalent ; Middle Aged ; Mortality ; Odds Ratio ; Physical activity ; Risk ; Risk Assessment ; Serology ; Sex Factors ; Spain ; Stomach ; Stomach cancer ; Stomach Neoplasms - diagnosis ; Stomach Neoplasms - pathology ; Stomach Neoplasms - prevention & control ; Surveys and Questionnaires ; Tumors ; Walking</subject><ispartof>PloS one, 2017-07, Vol.12 (7), p.e0179731-e0179731</ispartof><rights>COPYRIGHT 2017 Public Library of Science</rights><rights>2017 Huerta et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2017 Huerta et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited https://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess</rights><rights>2017 Huerta et al 2017 Huerta et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c734t-48644bf2936363cf8727c43db0e296390ba34d1f857960513814fba3c1f9e1c53</citedby><cites>FETCH-LOGICAL-c734t-48644bf2936363cf8727c43db0e296390ba34d1f857960513814fba3c1f9e1c53</cites><orcidid>0000-0002-9637-3869</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500262/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500262/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,26951,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28683070$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huerta, José M</creatorcontrib><creatorcontrib>Chirlaque, María Dolores</creatorcontrib><creatorcontrib>Molina, Antonio J</creatorcontrib><creatorcontrib>Amiano, Pilar</creatorcontrib><creatorcontrib>Martín, Vicente</creatorcontrib><creatorcontrib>Fernández-Villa, Tania</creatorcontrib><creatorcontrib>Pérez-Gómez, Beatriz</creatorcontrib><creatorcontrib>Moreno, Víctor</creatorcontrib><creatorcontrib>Burgui, Rosana</creatorcontrib><creatorcontrib>Gómez-Acebo, Inés</creatorcontrib><creatorcontrib>Ramos-Lora, Manuel</creatorcontrib><creatorcontrib>Fernández-Tardón, Guillermo</creatorcontrib><creatorcontrib>Peiró, Rosana</creatorcontrib><creatorcontrib>Olmedo-Requena, Rocío</creatorcontrib><creatorcontrib>Pollán, Marina</creatorcontrib><creatorcontrib>Kogevinas, Manolis</creatorcontrib><creatorcontrib>Castaño-Vinyals, Gemma</creatorcontrib><creatorcontrib>Aragonés, Nuria</creatorcontrib><creatorcontrib>Navarro</creatorcontrib><title>Physical activity domains and risk of gastric adenocarcinoma in the MCC-Spain case-control study</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Evidence for a protective role of physical activity against development of stomach cancer is yet inconclusive. We studied the association of domain-specific physical activity and the risk of gastric adenocarcinoma (GAC), by site and histology, in the MCC-Spain case-control study.
428 histologically confirmed GAC cases (67% men) including the gastro-esophageal region and 3225 controls were included. Cases were recruited in hospitals from 10 different Spanish regions, whereas population controls were randomly selected within the respective hospitals' catchment areas. A physical activity (PA) questionnaire was used to gather information on household and recreational activities, allowing estimation of PA volume (in metabolic equivalents (MET)-min/week). Participants also reported the intensity of working PA and daily sitting time. Questionnaire data on diet, lifestyles and clinical variables including Helicobacter pylori serology were available. Adjusted odds ratios (OR) of GAC were estimated for domains of physical activity, stratifying by sex, site (cardia vs. non-cardia), and Lauren classification (intestinal vs. diffuse).
Household physical activity (HPA) showed a strong inverse association with GAC, observed for both cardia and non-cardia tumours. Risk of overall gastric cancer was 50% lower risk among participants in the highest HPA category (OR = 0.50, 95%CI: 0.38, 0.66). Recreational physical activity (RPA) was also associated with lower overall GAC risk (OR = 0.68, 95% CI: 0.52, 0.88), particularly at moderate levels of intensity such as walking (OR = 0.61, 95% CI: 0.46, 0.79). The protective effect of RPA was strongest for non-cardia tumours. Sedentary time was not related to GAC risk (p-trend = 0.392), but the potential protective effect of RPA was restricted to non-sedentary participants.
Both household and recreational physical activities were independently related to lower GAC risk in the MCC-Spain study.</description><subject>Adenocarcinoma</subject><subject>Adenocarcinoma - diagnosis</subject><subject>Adenocarcinoma - pathology</subject><subject>Adenocarcinoma - prevention & control</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alcohol use</subject><subject>Biology and Life Sciences</subject><subject>Cancer</subject><subject>Cancer research</subject><subject>Case studies</subject><subject>Case-Control Studies</subject><subject>Catchment areas</subject><subject>Classification</subject><subject>Control methods</subject><subject>Càncer</subject><subject>Disease prevention</subject><subject>Epidemiology</subject><subject>Esophagus</subject><subject>Estómac</subject><subject>Exercici</subject><subject>Exercise</subject><subject>Female</subject><subject>Gastric cancer</subject><subject>Health aspects</subject><subject>Health risk assessment</subject><subject>Health risks</subject><subject>Helicobacter pylori</subject><subject>Histology</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Intestine</subject><subject>Male</subject><subject>Medicine and Health Sciences</subject><subject>Men</subject><subject>Metabolic Equivalent</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Odds Ratio</subject><subject>Physical activity</subject><subject>Risk</subject><subject>Risk Assessment</subject><subject>Serology</subject><subject>Sex Factors</subject><subject>Spain</subject><subject>Stomach</subject><subject>Stomach cancer</subject><subject>Stomach Neoplasms - diagnosis</subject><subject>Stomach Neoplasms - pathology</subject><subject>Stomach Neoplasms - prevention & control</subject><subject>Surveys and Questionnaires</subject><subject>Tumors</subject><subject>Walking</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>XX2</sourceid><sourceid>DOA</sourceid><recordid>eNqNk11v0zAUhiMEYmPwDxBYQkJwkeKv2MnNpKnio9LQEANujevYrUdqF9uZ6L_HbbOqQbtAVpTk5Hlf55zjUxTPEZwgwtG7G98HJ7vJ2js9gYg3nKAHxSlqCC4ZhuTh0fNJ8STGGwgrUjP2uDjBNasJ5PC0-PlluYlWyQ5IleytTRvQ-pW0LgLpWhBs_AW8AQsZU7AKyFY7r2RQ1mUKWAfSUoPP02l5vc4ioGTUpfIuBd-BmPp287R4ZGQX9bPhflZ8__D-2_RTeXn1cTa9uCwVJzSVtGaUzg1uCMtLmZpjrihp51DjhpEGziWhLTJ1xRsGK0RqRE2OKWQajVRFzoqXe99156MYihMFahBjNeKIZWK2J1ovb8Q62JUMG-GlFbuADwshQ7Kq00JThBhGBkHDacWlpLDCNZIIN0pR2mSv82G3fr7SrdI5Y9mNTMdfnF2Khb8VVQUhZjgboL2Bir0SQSsdlEw74eFle2HIsSAENgRmzZth0-B_9zomsbJR6a6TTvt-lysnrMZka__qH_T-igzUQuakrTM-_6vamoqLipJceMZQpib3UHm1emVzr7WxOT4SvB0JtudB_0kL2ccoZtdf_5-9-jFmXx-xSy27tIy-65P1Lo5BOhQ3-BiDNofGICi2w3NXDbEdHjEMT5a9OG7qQXQ3LeQvbDAR5Q</recordid><startdate>20170706</startdate><enddate>20170706</enddate><creator>Huerta, José M</creator><creator>Chirlaque, María Dolores</creator><creator>Molina, Antonio J</creator><creator>Amiano, Pilar</creator><creator>Martín, Vicente</creator><creator>Fernández-Villa, Tania</creator><creator>Pérez-Gómez, Beatriz</creator><creator>Moreno, Víctor</creator><creator>Burgui, Rosana</creator><creator>Gómez-Acebo, Inés</creator><creator>Ramos-Lora, Manuel</creator><creator>Fernández-Tardón, Guillermo</creator><creator>Peiró, Rosana</creator><creator>Olmedo-Requena, Rocío</creator><creator>Pollán, Marina</creator><creator>Kogevinas, Manolis</creator><creator>Castaño-Vinyals, Gemma</creator><creator>Aragonés, Nuria</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>XX2</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-9637-3869</orcidid></search><sort><creationdate>20170706</creationdate><title>Physical activity domains and risk of gastric adenocarcinoma in the MCC-Spain case-control study</title><author>Huerta, José M ; Chirlaque, María Dolores ; Molina, Antonio J ; Amiano, Pilar ; Martín, Vicente ; Fernández-Villa, Tania ; Pérez-Gómez, Beatriz ; Moreno, Víctor ; Burgui, Rosana ; Gómez-Acebo, Inés ; Ramos-Lora, Manuel ; Fernández-Tardón, Guillermo ; Peiró, Rosana ; Olmedo-Requena, Rocío ; Pollán, Marina ; Kogevinas, Manolis ; Castaño-Vinyals, Gemma ; Aragonés, Nuria</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c734t-48644bf2936363cf8727c43db0e296390ba34d1f857960513814fba3c1f9e1c53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adenocarcinoma</topic><topic>Adenocarcinoma - diagnosis</topic><topic>Adenocarcinoma - pathology</topic><topic>Adenocarcinoma - prevention & control</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alcohol use</topic><topic>Biology and Life Sciences</topic><topic>Cancer</topic><topic>Cancer research</topic><topic>Case studies</topic><topic>Case-Control Studies</topic><topic>Catchment areas</topic><topic>Classification</topic><topic>Control methods</topic><topic>Càncer</topic><topic>Disease prevention</topic><topic>Epidemiology</topic><topic>Esophagus</topic><topic>Estómac</topic><topic>Exercici</topic><topic>Exercise</topic><topic>Female</topic><topic>Gastric cancer</topic><topic>Health aspects</topic><topic>Health risk assessment</topic><topic>Health risks</topic><topic>Helicobacter pylori</topic><topic>Histology</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Intestine</topic><topic>Male</topic><topic>Medicine and Health Sciences</topic><topic>Men</topic><topic>Metabolic Equivalent</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Odds Ratio</topic><topic>Physical activity</topic><topic>Risk</topic><topic>Risk Assessment</topic><topic>Serology</topic><topic>Sex Factors</topic><topic>Spain</topic><topic>Stomach</topic><topic>Stomach cancer</topic><topic>Stomach Neoplasms - diagnosis</topic><topic>Stomach Neoplasms - pathology</topic><topic>Stomach Neoplasms - prevention & control</topic><topic>Surveys and Questionnaires</topic><topic>Tumors</topic><topic>Walking</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huerta, José M</creatorcontrib><creatorcontrib>Chirlaque, María Dolores</creatorcontrib><creatorcontrib>Molina, Antonio J</creatorcontrib><creatorcontrib>Amiano, Pilar</creatorcontrib><creatorcontrib>Martín, Vicente</creatorcontrib><creatorcontrib>Fernández-Villa, Tania</creatorcontrib><creatorcontrib>Pérez-Gómez, Beatriz</creatorcontrib><creatorcontrib>Moreno, Víctor</creatorcontrib><creatorcontrib>Burgui, Rosana</creatorcontrib><creatorcontrib>Gómez-Acebo, Inés</creatorcontrib><creatorcontrib>Ramos-Lora, Manuel</creatorcontrib><creatorcontrib>Fernández-Tardón, Guillermo</creatorcontrib><creatorcontrib>Peiró, Rosana</creatorcontrib><creatorcontrib>Olmedo-Requena, Rocío</creatorcontrib><creatorcontrib>Pollán, Marina</creatorcontrib><creatorcontrib>Kogevinas, Manolis</creatorcontrib><creatorcontrib>Castaño-Vinyals, Gemma</creatorcontrib><creatorcontrib>Aragonés, Nuria</creatorcontrib><creatorcontrib>Navarro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Recercat</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huerta, José M</au><au>Chirlaque, María Dolores</au><au>Molina, Antonio J</au><au>Amiano, Pilar</au><au>Martín, Vicente</au><au>Fernández-Villa, Tania</au><au>Pérez-Gómez, Beatriz</au><au>Moreno, Víctor</au><au>Burgui, Rosana</au><au>Gómez-Acebo, Inés</au><au>Ramos-Lora, Manuel</au><au>Fernández-Tardón, Guillermo</au><au>Peiró, Rosana</au><au>Olmedo-Requena, Rocío</au><au>Pollán, Marina</au><au>Kogevinas, Manolis</au><au>Castaño-Vinyals, Gemma</au><au>Aragonés, Nuria</au><aucorp>Navarro</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Physical activity domains and risk of gastric adenocarcinoma in the MCC-Spain case-control study</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2017-07-06</date><risdate>2017</risdate><volume>12</volume><issue>7</issue><spage>e0179731</spage><epage>e0179731</epage><pages>e0179731-e0179731</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Evidence for a protective role of physical activity against development of stomach cancer is yet inconclusive. We studied the association of domain-specific physical activity and the risk of gastric adenocarcinoma (GAC), by site and histology, in the MCC-Spain case-control study.
428 histologically confirmed GAC cases (67% men) including the gastro-esophageal region and 3225 controls were included. Cases were recruited in hospitals from 10 different Spanish regions, whereas population controls were randomly selected within the respective hospitals' catchment areas. A physical activity (PA) questionnaire was used to gather information on household and recreational activities, allowing estimation of PA volume (in metabolic equivalents (MET)-min/week). Participants also reported the intensity of working PA and daily sitting time. Questionnaire data on diet, lifestyles and clinical variables including Helicobacter pylori serology were available. Adjusted odds ratios (OR) of GAC were estimated for domains of physical activity, stratifying by sex, site (cardia vs. non-cardia), and Lauren classification (intestinal vs. diffuse).
Household physical activity (HPA) showed a strong inverse association with GAC, observed for both cardia and non-cardia tumours. Risk of overall gastric cancer was 50% lower risk among participants in the highest HPA category (OR = 0.50, 95%CI: 0.38, 0.66). Recreational physical activity (RPA) was also associated with lower overall GAC risk (OR = 0.68, 95% CI: 0.52, 0.88), particularly at moderate levels of intensity such as walking (OR = 0.61, 95% CI: 0.46, 0.79). The protective effect of RPA was strongest for non-cardia tumours. Sedentary time was not related to GAC risk (p-trend = 0.392), but the potential protective effect of RPA was restricted to non-sedentary participants.
Both household and recreational physical activities were independently related to lower GAC risk in the MCC-Spain study.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>28683070</pmid><doi>10.1371/journal.pone.0179731</doi><tpages>e0179731</tpages><orcidid>https://orcid.org/0000-0002-9637-3869</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2017-07, Vol.12 (7), p.e0179731-e0179731 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1916681716 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Recercat; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Adenocarcinoma Adenocarcinoma - diagnosis Adenocarcinoma - pathology Adenocarcinoma - prevention & control Aged Aged, 80 and over Alcohol use Biology and Life Sciences Cancer Cancer research Case studies Case-Control Studies Catchment areas Classification Control methods Càncer Disease prevention Epidemiology Esophagus Estómac Exercici Exercise Female Gastric cancer Health aspects Health risk assessment Health risks Helicobacter pylori Histology Hospitals Humans Intestine Male Medicine and Health Sciences Men Metabolic Equivalent Middle Aged Mortality Odds Ratio Physical activity Risk Risk Assessment Serology Sex Factors Spain Stomach Stomach cancer Stomach Neoplasms - diagnosis Stomach Neoplasms - pathology Stomach Neoplasms - prevention & control Surveys and Questionnaires Tumors Walking |
| title | Physical activity domains and risk of gastric adenocarcinoma in the MCC-Spain case-control study |
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