Human bone marrow harbors cells with neural crest-associated characteristics like human adipose and dermis tissues
Adult neural crest stem-derived cells (NCSC) are of extraordinary high plasticity and promising candidates for use in regenerative medicine. Several locations such as skin, adipose tissue, dental pulp or bone marrow have been described in rodent, as sources of NCSC. However, very little information...
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| Veröffentlicht in: | PloS one 2017-07, Vol.12 (7), p.e0177962-e0177962 |
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| creator | Coste, Cécile Neirinckx, Virginie Sharma, Anil Agirman, Gulistan Rogister, Bernard Foguenne, Jacques Lallemend, François Gothot, André Wislet, Sabine |
| description | Adult neural crest stem-derived cells (NCSC) are of extraordinary high plasticity and promising candidates for use in regenerative medicine. Several locations such as skin, adipose tissue, dental pulp or bone marrow have been described in rodent, as sources of NCSC. However, very little information is available concerning their correspondence in human tissues, and more precisely for human bone marrow. The main objective of this study was therefore to characterize NCSC from adult human bone marrow. In this purpose, we compared human bone marrow stromal cells to human adipose tissue and dermis, already described for containing NCSC. We performed comparative analyses in terms of gene and protein expression as well as functional characterizations. It appeared that human bone marrow, similarly to adipose tissue and dermis, contains NESTIN+ / SOX9+ / TWIST+ / SLUG+ / P75NTR+ / BRN3A+/ MSI1+/ SNAIL1+ cells and were able to differentiate into melanocytes, Schwann cells and neurons. Moreover, when injected into chicken embryos, all those cells were able to migrate and follow endogenous neural crest migration pathways. Altogether, the phenotypic characterization and migration abilities strongly suggest the presence of neural crest-derived cells in human adult bone marrow. |
| doi_str_mv | 10.1371/journal.pone.0177962 |
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Several locations such as skin, adipose tissue, dental pulp or bone marrow have been described in rodent, as sources of NCSC. However, very little information is available concerning their correspondence in human tissues, and more precisely for human bone marrow. The main objective of this study was therefore to characterize NCSC from adult human bone marrow. In this purpose, we compared human bone marrow stromal cells to human adipose tissue and dermis, already described for containing NCSC. We performed comparative analyses in terms of gene and protein expression as well as functional characterizations. It appeared that human bone marrow, similarly to adipose tissue and dermis, contains NESTIN+ / SOX9+ / TWIST+ / SLUG+ / P75NTR+ / BRN3A+/ MSI1+/ SNAIL1+ cells and were able to differentiate into melanocytes, Schwann cells and neurons. Moreover, when injected into chicken embryos, all those cells were able to migrate and follow endogenous neural crest migration pathways. Altogether, the phenotypic characterization and migration abilities strongly suggest the presence of neural crest-derived cells in human adult bone marrow.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0177962</identifier><identifier>PMID: 28683107</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adipose tissue ; Adipose Tissue - cytology ; Adipose Tissue - metabolism ; Adipose Tissue/cytology/metabolism ; Adult ; Animals ; Biology and Life Sciences ; Biomarkers - metabolism ; Bone marrow ; Bone Marrow Cells - cytology ; Bone Marrow Cells - metabolism ; Bone Marrow Cells/cytology/metabolism ; Brn-3 protein ; Cell adhesion & migration ; Cell Differentiation ; Chick Embryo ; Comparative analysis ; Dental pulp ; Dermis ; Dermis - cytology ; Dermis - metabolism ; Dermis/cytology/metabolism ; Embryos ; Ethics ; Female ; Gene Expression ; Hair ; Hematology ; Human health sciences ; Human performance ; Human tissues ; Humans ; Hématologie ; Immunology ; Laboratories ; Medicine and Health Sciences ; Melanocytes ; Melanocytes - cytology ; Melanocytes - metabolism ; Melanocytes/cytology/metabolism ; Mesenchymal Stem Cell Transplantation ; Mesenchymal stem cells ; Mesenchymal Stromal Cells - cytology ; Mesenchymal Stromal Cells - metabolism ; Mesenchymal Stromal Cells/cytology/metabolism ; Microinjections ; Msi1 protein ; Nerve Tissue Proteins - genetics ; Nerve Tissue Proteins - metabolism ; Nerve Tissue Proteins/genetics/metabolism ; Nervous system ; Nestin ; Nestin - genetics ; Nestin - metabolism ; Nestin/genetics/metabolism ; Neural crest ; Neural Crest - cytology ; Neural Crest - growth & development ; Neural Crest - metabolism ; Neural Crest/cytology/growth & development/metabolism ; Neural plasticity ; Neural Stem Cells - cytology ; Neural Stem Cells - metabolism ; Neural Stem Cells/cytology/metabolism ; Neurons ; Neurons - cytology ; Neurons - metabolism ; Neurons/cytology/metabolism ; Neuroplasticity ; Neurosciences ; Nuclear Proteins - genetics ; Nuclear Proteins - metabolism ; Nuclear Proteins/genetics/metabolism ; People and Places ; Receptors, Nerve Growth Factor - genetics ; Receptors, Nerve Growth Factor - metabolism ; Receptors, Nerve Growth Factor/genetics/metabolism ; Regenerative medicine ; RNA-Binding Proteins - genetics ; RNA-Binding Proteins - metabolism ; RNA-Binding Proteins/genetics/metabolism ; Schwann cells ; Schwann Cells - cytology ; Schwann Cells - metabolism ; Schwann Cells/cytology/metabolism ; Sciences de la santé humaine ; Skin ; Snail Family Transcription Factors - genetics ; Snail Family Transcription Factors - metabolism ; Snail Family Transcription Factors/genetics/metabolism ; Sox9 protein ; SOX9 Transcription Factor - genetics ; SOX9 Transcription Factor - metabolism ; SOX9 Transcription Factor/genetics/metabolism ; Stem cells ; Stromal cells ; Surgery ; Tissue engineering ; Transcription Factor Brn-3A - genetics ; Transcription Factor Brn-3A - metabolism ; Transcription Factor Brn-3A/genetics/metabolism ; Twist-Related Protein 1 - genetics ; Twist-Related Protein 1 - metabolism ; Twist-Related Protein 1/genetics/metabolism</subject><ispartof>PloS one, 2017-07, Vol.12 (7), p.e0177962-e0177962</ispartof><rights>COPYRIGHT 2017 Public Library of Science</rights><rights>2017 Coste et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2017 Coste et al 2017 Coste et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c774t-38ca106d0d63ec082aadbf8fed0fc0f64a7970f4bb66f59223d4610f37c845813</citedby><cites>FETCH-LOGICAL-c774t-38ca106d0d63ec082aadbf8fed0fc0f64a7970f4bb66f59223d4610f37c845813</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500284/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500284/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,550,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28683107$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:136280958$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Coste, Cécile</creatorcontrib><creatorcontrib>Neirinckx, Virginie</creatorcontrib><creatorcontrib>Sharma, Anil</creatorcontrib><creatorcontrib>Agirman, Gulistan</creatorcontrib><creatorcontrib>Rogister, Bernard</creatorcontrib><creatorcontrib>Foguenne, Jacques</creatorcontrib><creatorcontrib>Lallemend, François</creatorcontrib><creatorcontrib>Gothot, André</creatorcontrib><creatorcontrib>Wislet, Sabine</creatorcontrib><title>Human bone marrow harbors cells with neural crest-associated characteristics like human adipose and dermis tissues</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Adult neural crest stem-derived cells (NCSC) are of extraordinary high plasticity and promising candidates for use in regenerative medicine. Several locations such as skin, adipose tissue, dental pulp or bone marrow have been described in rodent, as sources of NCSC. However, very little information is available concerning their correspondence in human tissues, and more precisely for human bone marrow. The main objective of this study was therefore to characterize NCSC from adult human bone marrow. In this purpose, we compared human bone marrow stromal cells to human adipose tissue and dermis, already described for containing NCSC. We performed comparative analyses in terms of gene and protein expression as well as functional characterizations. It appeared that human bone marrow, similarly to adipose tissue and dermis, contains NESTIN+ / SOX9+ / TWIST+ / SLUG+ / P75NTR+ / BRN3A+/ MSI1+/ SNAIL1+ cells and were able to differentiate into melanocytes, Schwann cells and neurons. Moreover, when injected into chicken embryos, all those cells were able to migrate and follow endogenous neural crest migration pathways. Altogether, the phenotypic characterization and migration abilities strongly suggest the presence of neural crest-derived cells in human adult bone marrow.</description><subject>Adipose tissue</subject><subject>Adipose Tissue - cytology</subject><subject>Adipose Tissue - metabolism</subject><subject>Adipose Tissue/cytology/metabolism</subject><subject>Adult</subject><subject>Animals</subject><subject>Biology and Life Sciences</subject><subject>Biomarkers - metabolism</subject><subject>Bone marrow</subject><subject>Bone Marrow Cells - cytology</subject><subject>Bone Marrow Cells - metabolism</subject><subject>Bone Marrow Cells/cytology/metabolism</subject><subject>Brn-3 protein</subject><subject>Cell adhesion & migration</subject><subject>Cell Differentiation</subject><subject>Chick Embryo</subject><subject>Comparative analysis</subject><subject>Dental pulp</subject><subject>Dermis</subject><subject>Dermis - cytology</subject><subject>Dermis - metabolism</subject><subject>Dermis/cytology/metabolism</subject><subject>Embryos</subject><subject>Ethics</subject><subject>Female</subject><subject>Gene Expression</subject><subject>Hair</subject><subject>Hematology</subject><subject>Human health sciences</subject><subject>Human performance</subject><subject>Human tissues</subject><subject>Humans</subject><subject>Hématologie</subject><subject>Immunology</subject><subject>Laboratories</subject><subject>Medicine and Health Sciences</subject><subject>Melanocytes</subject><subject>Melanocytes - cytology</subject><subject>Melanocytes - metabolism</subject><subject>Melanocytes/cytology/metabolism</subject><subject>Mesenchymal Stem Cell Transplantation</subject><subject>Mesenchymal stem cells</subject><subject>Mesenchymal Stromal Cells - cytology</subject><subject>Mesenchymal Stromal Cells - metabolism</subject><subject>Mesenchymal Stromal Cells/cytology/metabolism</subject><subject>Microinjections</subject><subject>Msi1 protein</subject><subject>Nerve Tissue Proteins - genetics</subject><subject>Nerve Tissue Proteins - metabolism</subject><subject>Nerve Tissue Proteins/genetics/metabolism</subject><subject>Nervous system</subject><subject>Nestin</subject><subject>Nestin - genetics</subject><subject>Nestin - metabolism</subject><subject>Nestin/genetics/metabolism</subject><subject>Neural crest</subject><subject>Neural Crest - cytology</subject><subject>Neural Crest - growth & development</subject><subject>Neural Crest - metabolism</subject><subject>Neural Crest/cytology/growth & development/metabolism</subject><subject>Neural plasticity</subject><subject>Neural Stem Cells - 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cytology</topic><topic>Melanocytes - metabolism</topic><topic>Melanocytes/cytology/metabolism</topic><topic>Mesenchymal Stem Cell Transplantation</topic><topic>Mesenchymal stem cells</topic><topic>Mesenchymal Stromal Cells - cytology</topic><topic>Mesenchymal Stromal Cells - metabolism</topic><topic>Mesenchymal Stromal Cells/cytology/metabolism</topic><topic>Microinjections</topic><topic>Msi1 protein</topic><topic>Nerve Tissue Proteins - genetics</topic><topic>Nerve Tissue Proteins - metabolism</topic><topic>Nerve Tissue Proteins/genetics/metabolism</topic><topic>Nervous system</topic><topic>Nestin</topic><topic>Nestin - genetics</topic><topic>Nestin - metabolism</topic><topic>Nestin/genetics/metabolism</topic><topic>Neural crest</topic><topic>Neural Crest - cytology</topic><topic>Neural Crest - growth & development</topic><topic>Neural Crest - metabolism</topic><topic>Neural Crest/cytology/growth & development/metabolism</topic><topic>Neural plasticity</topic><topic>Neural Stem Cells - cytology</topic><topic>Neural Stem Cells - metabolism</topic><topic>Neural Stem Cells/cytology/metabolism</topic><topic>Neurons</topic><topic>Neurons - cytology</topic><topic>Neurons - metabolism</topic><topic>Neurons/cytology/metabolism</topic><topic>Neuroplasticity</topic><topic>Neurosciences</topic><topic>Nuclear Proteins - genetics</topic><topic>Nuclear Proteins - metabolism</topic><topic>Nuclear Proteins/genetics/metabolism</topic><topic>People and Places</topic><topic>Receptors, Nerve Growth Factor - genetics</topic><topic>Receptors, Nerve Growth Factor - metabolism</topic><topic>Receptors, Nerve Growth Factor/genetics/metabolism</topic><topic>Regenerative medicine</topic><topic>RNA-Binding Proteins - genetics</topic><topic>RNA-Binding Proteins - metabolism</topic><topic>RNA-Binding Proteins/genetics/metabolism</topic><topic>Schwann cells</topic><topic>Schwann Cells - cytology</topic><topic>Schwann Cells - metabolism</topic><topic>Schwann Cells/cytology/metabolism</topic><topic>Sciences de la santé humaine</topic><topic>Skin</topic><topic>Snail Family Transcription Factors - genetics</topic><topic>Snail Family Transcription Factors - metabolism</topic><topic>Snail Family Transcription Factors/genetics/metabolism</topic><topic>Sox9 protein</topic><topic>SOX9 Transcription Factor - genetics</topic><topic>SOX9 Transcription Factor - metabolism</topic><topic>SOX9 Transcription Factor/genetics/metabolism</topic><topic>Stem cells</topic><topic>Stromal cells</topic><topic>Surgery</topic><topic>Tissue engineering</topic><topic>Transcription Factor Brn-3A - genetics</topic><topic>Transcription Factor Brn-3A - metabolism</topic><topic>Transcription Factor Brn-3A/genetics/metabolism</topic><topic>Twist-Related Protein 1 - genetics</topic><topic>Twist-Related Protein 1 - metabolism</topic><topic>Twist-Related Protein 1/genetics/metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Coste, Cécile</creatorcontrib><creatorcontrib>Neirinckx, Virginie</creatorcontrib><creatorcontrib>Sharma, Anil</creatorcontrib><creatorcontrib>Agirman, Gulistan</creatorcontrib><creatorcontrib>Rogister, Bernard</creatorcontrib><creatorcontrib>Foguenne, Jacques</creatorcontrib><creatorcontrib>Lallemend, François</creatorcontrib><creatorcontrib>Gothot, André</creatorcontrib><creatorcontrib>Wislet, Sabine</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Université de Liège - Open Repository and Bibliography (ORBI)</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Coste, Cécile</au><au>Neirinckx, Virginie</au><au>Sharma, Anil</au><au>Agirman, Gulistan</au><au>Rogister, Bernard</au><au>Foguenne, Jacques</au><au>Lallemend, François</au><au>Gothot, André</au><au>Wislet, Sabine</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Human bone marrow harbors cells with neural crest-associated characteristics like human adipose and dermis tissues</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2017-07-06</date><risdate>2017</risdate><volume>12</volume><issue>7</issue><spage>e0177962</spage><epage>e0177962</epage><pages>e0177962-e0177962</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Adult neural crest stem-derived cells (NCSC) are of extraordinary high plasticity and promising candidates for use in regenerative medicine. Several locations such as skin, adipose tissue, dental pulp or bone marrow have been described in rodent, as sources of NCSC. However, very little information is available concerning their correspondence in human tissues, and more precisely for human bone marrow. The main objective of this study was therefore to characterize NCSC from adult human bone marrow. In this purpose, we compared human bone marrow stromal cells to human adipose tissue and dermis, already described for containing NCSC. We performed comparative analyses in terms of gene and protein expression as well as functional characterizations. It appeared that human bone marrow, similarly to adipose tissue and dermis, contains NESTIN+ / SOX9+ / TWIST+ / SLUG+ / P75NTR+ / BRN3A+/ MSI1+/ SNAIL1+ cells and were able to differentiate into melanocytes, Schwann cells and neurons. Moreover, when injected into chicken embryos, all those cells were able to migrate and follow endogenous neural crest migration pathways. Altogether, the phenotypic characterization and migration abilities strongly suggest the presence of neural crest-derived cells in human adult bone marrow.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>28683107</pmid><doi>10.1371/journal.pone.0177962</doi><tpages>e0177962</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2017-07, Vol.12 (7), p.e0177962-e0177962 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1916680808 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; SWEPUB Freely available online; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Adipose tissue Adipose Tissue - cytology Adipose Tissue - metabolism Adipose Tissue/cytology/metabolism Adult Animals Biology and Life Sciences Biomarkers - metabolism Bone marrow Bone Marrow Cells - cytology Bone Marrow Cells - metabolism Bone Marrow Cells/cytology/metabolism Brn-3 protein Cell adhesion & migration Cell Differentiation Chick Embryo Comparative analysis Dental pulp Dermis Dermis - cytology Dermis - metabolism Dermis/cytology/metabolism Embryos Ethics Female Gene Expression Hair Hematology Human health sciences Human performance Human tissues Humans Hématologie Immunology Laboratories Medicine and Health Sciences Melanocytes Melanocytes - cytology Melanocytes - metabolism Melanocytes/cytology/metabolism Mesenchymal Stem Cell Transplantation Mesenchymal stem cells Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - metabolism Mesenchymal Stromal Cells/cytology/metabolism Microinjections Msi1 protein Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Nerve Tissue Proteins/genetics/metabolism Nervous system Nestin Nestin - genetics Nestin - metabolism Nestin/genetics/metabolism Neural crest Neural Crest - cytology Neural Crest - growth & development Neural Crest - metabolism Neural Crest/cytology/growth & development/metabolism Neural plasticity Neural Stem Cells - cytology Neural Stem Cells - metabolism Neural Stem Cells/cytology/metabolism Neurons Neurons - cytology Neurons - metabolism Neurons/cytology/metabolism Neuroplasticity Neurosciences Nuclear Proteins - genetics Nuclear Proteins - metabolism Nuclear Proteins/genetics/metabolism People and Places Receptors, Nerve Growth Factor - genetics Receptors, Nerve Growth Factor - metabolism Receptors, Nerve Growth Factor/genetics/metabolism Regenerative medicine RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism RNA-Binding Proteins/genetics/metabolism Schwann cells Schwann Cells - cytology Schwann Cells - metabolism Schwann Cells/cytology/metabolism Sciences de la santé humaine Skin Snail Family Transcription Factors - genetics Snail Family Transcription Factors - metabolism Snail Family Transcription Factors/genetics/metabolism Sox9 protein SOX9 Transcription Factor - genetics SOX9 Transcription Factor - metabolism SOX9 Transcription Factor/genetics/metabolism Stem cells Stromal cells Surgery Tissue engineering Transcription Factor Brn-3A - genetics Transcription Factor Brn-3A - metabolism Transcription Factor Brn-3A/genetics/metabolism Twist-Related Protein 1 - genetics Twist-Related Protein 1 - metabolism Twist-Related Protein 1/genetics/metabolism |
| title | Human bone marrow harbors cells with neural crest-associated characteristics like human adipose and dermis tissues |
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