Comparison of quantitative real-time PCR and direct immunofluorescence for the detection of Pneumocystis jirovecii

Pneumocystis pneumonia (PCP) is a serious risk for HIV-positive patients. Asymptomatic infection or colonisation with P. jirovecii has been shown to occur frequently. PCR assays frequently identify such cases, due to their high sensitivity. Quantitative real-time PCR (qPCR) gene copy number cut-off...

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Veröffentlicht in:	PloS one 2017-07, Vol.12 (7), p.e0180589-e0180589
Hauptverfasser:	Moodley, Bhavani, Tempia, Stefano, Frean, John Andrew
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Analysis Assaying Asymptomatic infection Biology and Life Sciences Colonization Copy number Cysts Deoxyribonucleic acid Diagnosis Disease control DNA Female Fluorescent antibody technique Fluorescent Antibody Technique, Direct - methods Health aspects Health risks HIV Human immunodeficiency virus Humans Immunofluorescence Infections Influenza Laboratories Male Medicine and Health Sciences Parasitic diseases Patients People and places Pneumocystis carinii - genetics Pneumocystis carinii - isolation & purification Pneumonia Pneumonia, Pneumocystis - diagnosis Pneumonia, Pneumocystis - microbiology Polymerase chain reaction Real time Real-Time Polymerase Chain Reaction - methods Research and Analysis Methods Sensitivity Sputum Zoonoses
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