Diabetes-induced oxidative stress mediates upregulation of RhoA/Rho kinase pathway and hypercontractility of gastric smooth muscle

The pathogenesis of diabetes-associated motility disorders are multifactorial and attributed to abnormalities in extrinsic and intrinsic innervation, and a decrease in the number of interstitial cells of Cajal, and nNOS expression and activity. Here we studied the effect of hyperglycemia on smooth m...

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Veröffentlicht in:	PloS one 2017-07, Vol.12 (7), p.e0178574
Hauptverfasser:	Mahavadi, Sunila, Sriwai, Wimolpak, Manion, Olivia, Grider, John R, Murthy, Karnam S
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities Acetylcysteine Acetylcysteine - pharmacology Animal models Animals Binding sites Biology and Life Sciences Biophysics Blotting, Western Cells, Cultured Cellular signal transduction Complications and side effects Diabetes Diabetes mellitus Diabetes Mellitus - genetics Diabetes Mellitus - metabolism Diabetes Mellitus - physiopathology Disorders Emptying Enzymes Fecal incontinence Free Radical Scavengers - pharmacology Gastric emptying Gastric Mucosa - metabolism Gastroenterology Gene Expression - drug effects Genetic aspects Glucose Glucose - pharmacology Health aspects Hydrogen Hydrogen peroxide Hyperglycemia Hyperglycemia - genetics Hyperglycemia - metabolism Hyperglycemia - physiopathology In vitro methods and tests Innervation Interstitial cells Interstitial cells of Cajal Kinases Medicine and Health Sciences Mice Mice, Inbred C57BL Mice, Obese MicroRNAs MicroRNAs - genetics Motility Muscle contraction Muscle Contraction - physiology Muscle, Smooth - metabolism Muscle, Smooth - physiology Muscles NAD(P)H oxidase Oxidative Stress Oxygen Pathogenesis Phosphorylation Phosphotransferases Physiology Proteins Reactive oxygen species Reverse Transcriptase Polymerase Chain Reaction Rho-associated kinase rho-Associated Kinases - genetics rho-Associated Kinases - metabolism rhoA GTP-Binding Protein - genetics rhoA GTP-Binding Protein - metabolism RhoA protein Rodents Signal Transduction - genetics Smooth muscle Stomach - physiology Superoxide dismutase Up-Regulation
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