Effects of low-dose rate γ-irradiation combined with simulated microgravity on markers of oxidative stress, DNA methylation potential, and remodeling in the mouse heart

Space travel is associated with an exposure to low-dose rate ionizing radiation and the microgravity environment, both of which may lead to impairments in cardiac function. We used a mouse model to determine short- and long-term cardiac effects to simulated microgravity (hindlimb unloading; HU), con...

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Veröffentlicht in:	PloS one 2017-07, Vol.12 (7), p.e0180594-e0180594
Hauptverfasser:	Seawright, John W, Samman, Yusra, Sridharan, Vijayalakshmi, Mao, Xiao Wen, Cao, Maohua, Singh, Preeti, Melnyk, Stepan, Koturbash, Igor, Nelson, Gregory A, Hauer-Jensen, Martin, Boerma, Marjan
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Hydroxynonenal Adducts Animals Antioxidants - metabolism Atherosclerosis Biology Biology and Life Sciences Breast cancer Cadmium Cardiovascular disease Catalase Chromatography Collagen (type III) Collagen - metabolism Computer simulation Deoxyribonucleic acid DNA DNA methylation DNA Methylation - radiation effects Dose-Response Relationship, Radiation Drug dosages Economic conditions Enzymes Enzymes - metabolism Exposure Female Gamma irradiation Gamma Rays Glutathione Heart - anatomy & histology Heart - radiation effects Heart diseases Heart failure Heart rate High performance liquid chromatography Histology Homocysteine Immune system Infiltration Inflammation Ionizing radiation Irradiation Liquid chromatography Lymphocytes T Manganese Markers Medical research Medicine and Health Sciences Metabolism Mice Mice, Inbred C57BL Microgravity Myocardium - enzymology Myocardium - metabolism Oxidative stress Oxidative Stress - radiation effects Pharmaceutical sciences Pharmaceuticals Physical Sciences Polymerase chain reaction Radiation Radiation dosage Radiation therapy Rodents Smooth muscle Space flight Superoxide dismutase Travel Weightlessness Simulation γ Radiation
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