Identifying novel genes and biological processes relevant to the development of cancer therapy-induced mucositis: An informative gene network analysis

Mucositis is a complex, dose-limiting toxicity of chemotherapy or radiotherapy that leads to painful mouth ulcers, difficulty eating or swallowing, gastrointestinal distress, and reduced quality of life for patients with cancer. Mucositis is most common for those undergoing high-dose chemotherapy an...

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Veröffentlicht in:	PloS one 2017-07, Vol.12 (7), p.e0180396
Hauptverfasser:	Reyes-Gibby, Cielito C, Melkonian, Stephanie C, Wang, Jian, Yu, Robert K, Shelburne, Samuel A, Lu, Charles, Gunn, Gary Brandon, Chambers, Mark S, Hanna, Ehab Y, Yeung, Sai-Ching J, Shete, Sanjay
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - adverse effects Antineoplastic Agents - therapeutic use Association analysis Biological activity Biology and life sciences Biopsy Cancer Cancer therapies Cancer treatment Chemotherapy Complexity Complications and side effects Degradation Development and progression Drug dosages Eating Emergency medical care ERCC1 protein Gene expression Gene Regulatory Networks Genes Genetic aspects Genetic Predisposition to Disease Genetic variance Head Head & neck cancer Head and neck cancer Head and Neck Neoplasms - drug therapy Head and Neck Neoplasms - genetics Humans Infectious diseases Literature reviews MAP kinase Medical research Medicine Medicine and Health Sciences Methylenetetrahydrofolate reductase Mucositis Mucositis - chemically induced Mucositis - genetics Mucositis - physiopathology Myc protein Network analysis Oncology Oxidative stress p53 Protein Patients Quality of life Radiation Radiation therapy Risk factors Single-nucleotide polymorphism Stem cell transplantation Stem cells Studies Surgery Swallowing Thymine Toxicity Transplantation Transplants & implants Ulcers Uracil
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