Cardioprotective effects of PKG activation by soluble GC activator, BAY 60-2770, in ischemia-reperfusion-injured rat hearts

Soluble guanylate cyclase (sGC) has been suggested as a therapeutic target for cardiac ischemia-reperfusion (IR) injury. Until now, the molecular mechanism of BAY 60-2770, a sGC activator, in cardiac IR injury has not been assessed. To identify the cardioprotective effects of BAY 60-2770 in IR-injur...

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Veröffentlicht in:	PloS one 2017-07, Vol.12 (7), p.e0180207-e0180207
Hauptverfasser:	Lee, Kyung Hye, Lee, So-Ra, Cho, Haneul, Woo, Jong Shin, Kang, Jung Hee, Jeong, Yun-Mi, Cheng, Xian Wu, Kim, Woo-Shik, Kim, Weon
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Animals Benzoates - pharmacology Biology and Life Sciences Biphenyl Compounds - pharmacology Care and treatment Cell Line Chemical compounds Coronary vessels Cyclic AMP Cyclic GMP Cyclic GMP-Dependent Protein Kinases - metabolism Echocardiography Enzyme Activation Guanylate cyclase Guanylate Cyclase - metabolism Heart Heart diseases Hospitals Hydrocarbons, Fluorinated - pharmacology Hypoxia In Vitro Techniques Injury prevention Internal medicine Ischemia Laboratory animals Male Medical research Medicine Medicine and Health Sciences Mitochondria Mitochondria, Heart - metabolism Myoblasts Myocardial Reperfusion Injury Myocardium Occlusion Oral administration Oxidative stress Oxidative Stress - drug effects Permeability Pharmacology Potassium Rats Rats, Sprague-Dawley Reactive oxygen species Reperfusion Research and Analysis Methods Rodents Staining Studies Superoxides - metabolism Therapeutics Veins & arteries Ventricle
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