Delivery of gene targeting siRNAs to breast cancer cells using a multifunctional peptide complex that promotes both targeted delivery and endosomal release

RNA interference has been used to dissect the importance of individual gene products in various human disease processes, including cancer. Small-interfering RNA, or siRNA, is one of the tools utilized in this regard, but specially-designed delivery agents are required to allow the siRNA to gain opti...

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Veröffentlicht in:	PloS one 2017-06, Vol.12 (6), p.e0180578-e0180578
Hauptverfasser:	Bjorge, Jeffrey D, Pang, Andy, Fujita, Donald J
Format:	Artikel
Sprache:	eng
Schlagworte:	Assaying Biochemistry Biology and life sciences Breast Breast cancer Breast Neoplasms - pathology Breast Neoplasms - therapy c-Myc protein Cancer Cancer cells Cell Line, Tumor Confocal Correlation analysis Cytoplasm Diagnosis Disease Drug Carriers Electron microscopy Endosomes Female Fluorescence Fluorescence microscopy Gene Targeting Genes Genes, myc Genetic aspects Humans Interference Medical research Medicine Medicine and Health Sciences Microscopy, Confocal Microscopy, Electron, Transmission Molecular biology Myc protein Myristoylation Nanoparticles Nuclease Particle physics Particulates Peptides Proteins Research and Analysis Methods Ribonucleic acid RNA RNA interference RNA, Small Interfering - genetics RNA-mediated interference Rodents siRNA Stat3 protein STAT3 Transcription Factor - genetics Tumorigenicity Tumors Vascular endothelial growth factor Vehicles
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