Molecular mechanics of Staphylococcus aureus adhesin, CNA, and the inhibition of bacterial adhesion by stretching collagen

Bacterial adhesion to collagen, the most abundant protein in humans, is a critical step in the initiation and persistence of numerous bacterial infections. In this study, we explore the collagen binding mechanism of the multi-modular cell wall anchored collagen adhesin (CNA) in Staphylococcus aureus...

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Veröffentlicht in:	PloS one 2017-06, Vol.12 (6), p.e0179601-e0179601
Hauptverfasser:	Madani, Ali, Garakani, Kiavash, Mofrad, Mohammad R K
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesins Adhesins, Bacterial - chemistry Adhesins, Bacterial - metabolism Adhesins, Bacterial - physiology Adhesion Analysis Antibiotic resistance Antibiotics Arthritis Bacteria Bacterial Adhesion - physiology Bacterial infections Binding sites Bioengineering Bioinformatics Biology and Life Sciences Biomechanics Cell walls Collagen Collagen - chemistry Collagen - metabolism Collagen - physiology Colonization Computer applications Computer simulation Dynamic structural analysis Endocarditis Engineering Extracellular matrix Fibers Fibronectins Functional morphology Health aspects Infections Inflammation Inhibition Ligands Locking Mechanics (physics) Medicine and Health Sciences Microbial drug resistance Molecular dynamics Molecular Dynamics Simulation Molecular modelling Pathogenesis Peptides Physical Sciences Protein Binding Protein Conformation Proteins Research and Analysis Methods Residues Sampling Science & Technology - Other Topics Staphylococcus aureus Staphylococcus infections Stretching Structure-function relationships Tensile Strength Tissues
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