HA117 endows HL60 cells with a stem-like signature by inhibiting the degradation of DNMT1 via its ability to down-regulate expression of the GGL domain of RGS6

All-trans retinoic acid (ATRA) induces complete remission in almost all patients with acute promyelocytic leukemia (APL) via its ability to induce the in vivo differentiation of APL blasts. However, prolonged ATRA treatment can result in drug resistance. In previous studies, we generated a multi-dru...

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Veröffentlicht in:	PloS one 2017-06, Vol.12 (6), p.e0180142-e0180142
Hauptverfasser:	Li, Shuangshuang, Jin, Xianqing, Wu, Huan, Wang, Yi, Li, Xiaoqing, Guo, Yuxia, Liang, Shaoyan
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute myelocytic leukemia Acute promyeloid leukemia Alternative splicing APL (programming language) Binding sites Biology and life sciences Brain cancer Cancer Cancer therapies CD123 antigen Cell cycle Child development Children & youth Cooperation Degradation Deoxyribonucleic acid Differentiation DNA DNA methylation DNA methyltransferase DNMT1 protein Down-Regulation Drug resistance Drug Resistance, Neoplasm Drug therapy Education Epigenetics Gastrointestinal surgery Gene expression Genes Genetic aspects HL-60 Cells Humans Laboratories Leukemia Leukemia, Promyelocytic, Acute - drug therapy Leukemia, Promyelocytic, Acute - pathology Markers Medicine and Health Sciences Multidrug resistance Neoplasm Proteins - physiology Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Patients Pediatrics Physiological aspects Polymerase chain reaction Promyeloid leukemia Proteins Proteolysis Real time Remission Repressor Proteins - metabolism Research and analysis methods Retinoic acid RGS Proteins - chemistry RGS Proteins - metabolism Science Steam Stem cells Subpopulations Tretinoin Tretinoin - pharmacology Tretinoin - therapeutic use Tumors Ubiquitination
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