A two-step approach for fluidized bed granulation in pharmaceutical processing: Assessing different models for design and control

Various modeling techniques were used to understand fluidized bed granulation using a two-step approach. First, Plackett-Burman design (PBD) was used to identify the high-risk factors. Then, Box-Behnken design (BBD) was used to analyze and optimize those high-risk factors. The relationship between t...

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Veröffentlicht in:	PloS one 2017-06, Vol.12 (6), p.e0180209-e0180209
Hauptverfasser:	Ming, Liangshan, Li, Zhe, Wu, Fei, Du, Ruofei, Feng, Yi
Format:	Artikel
Sprache:	eng
Schlagworte:	Agglomeration Air temperature Artificial neural networks Biology and Life Sciences Chinese medicine Computer and Information Sciences Design Design analysis Design factors Design optimization Developmental stages Fluidized bed combustion Fluidized bed reactors Fluidized beds Granular materials Granulation Granules Least squares method Mathematical models Methods Microfluidics Microscopy, Electron, Scanning Models, Chemical Moisture content Neural networks Pharmaceuticals Physical Sciences Powder Powders (Particulate matter) Process parameters Quality management Research and Analysis Methods Risk analysis Risk factors Scanning electron microscopy Statistical analysis Statistics Technology, Pharmaceutical - methods Temperature effects
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