Increased dermal collagen bundle alignment in systemic sclerosis is associated with a cell migration signature and role of Arhgdib in directed fibroblast migration on aligned ECMs

Systemic sclerosis (SSc) is a devastating disease affecting the skin and internal organs. Dermal fibrosis manifests early and Modified Rodnan Skin Scores (MRSS) correlate with disease progression. Transcriptomics of SSc skin biopsies suggest the role of the in vivo microenvironment in maintaining th...

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Veröffentlicht in:	PloS one 2017-06, Vol.12 (6), p.e0180751-e0180751
Hauptverfasser:	Cao, Lizhi, Lafyatis, Robert, Burkly, Linda C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesion Adult Aged Alignment Animals Arthritis Biology and Life Sciences Biopsy Bleomycin Bundles Bundling Cell migration Cell Movement Collagen Collagen - metabolism Correlation analysis Cytokinesis Development and progression Dissociation Dosage and administration Electrochemical machining Extracellular matrix Extracellular Matrix - metabolism Fibers Fibroblasts Fibroblasts - cytology Fibrosis Gene expression Genomes Humans Image analysis Image processing In vitro methods and tests Inhibitors Intervention Laboratory animals Leukocyte migration Medicine Medicine and Health Sciences Mice Middle Aged Organs Pathogenesis Pathways Patients Replication Rheumatism rho Guanine Nucleotide Dissociation Inhibitor beta - genetics rho Guanine Nucleotide Dissociation Inhibitor beta - physiology Scleroderma Scleroderma (Disease) Scleroderma, Systemic - metabolism Scleroderma, Systemic - pathology Skin Skin - metabolism Skin diseases Systemic sclerosis
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