Using c-kit to genetically target cerebellar molecular layer interneurons in adult mice

The cerebellar system helps modulate and fine-tune motor action. Purkinje cells (PCs) provide the sole output of the cerebellar cortex, therefore, any cerebellar involvement in motor activity must be driven by changes in PC firing rates. Several different cell types influence PC activity including e...

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Veröffentlicht in:	PloS one 2017-06, Vol.12 (6), p.e0179347-e0179347
Hauptverfasser:	Amat, Samantha B, Rowan, Matthew J M, Gaffield, Michael A, Bonnan, Audrey, Kikuchi, Chikako, Taniguchi, Hiroki, Christie, Jason M
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - physiology Animals Biology and Life Sciences c-Kit protein Cerebellar Cortex - cytology Cerebellar Cortex - metabolism Cerebellum Cerebellum - cytology Cerebellum - metabolism Cloning Cortex (motor) Cre recombinase Fibers Gene expression Genetic engineering In vitro methods and tests Inhibition Interneurons Interneurons - cytology Interneurons - metabolism Kinases Machinery Machinery and equipment Medicine and Health Sciences Mice Mice, Transgenic Motor activity Motor task performance Neurosciences Parallel fibers Principal components analysis Proto-Oncogene Proteins c-kit - genetics Proto-Oncogene Proteins c-kit - metabolism Purkinje cells Recombinase Research and Analysis Methods Transcription
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