Biliary drainage improves the predictive value of modified Glasgow Prognostic Scores in inoperable pancreatic cancer
To assess the influence of biliary drainage to cholangitis on modified Glasgow Prognostic Score (mGPS) in patients with pancreatic cancer. mGPS was calculated before and after biliary drainage in 47 consecutive patients with inoperable pancreatic cancer who were receiving chemotherapy. Biliary drain...
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| creator | Iino, Chikara Shimoyama, Tadashi Igarashi, Takasato Aihara, Tomoyuki Ishii, Kentaro Sakamoto, Juichi Tono, Hiroshi Fukuda, Shinsaku |
| description | To assess the influence of biliary drainage to cholangitis on modified Glasgow Prognostic Score (mGPS) in patients with pancreatic cancer.
mGPS was calculated before and after biliary drainage in 47 consecutive patients with inoperable pancreatic cancer who were receiving chemotherapy. Biliary drainage was indicated for malignant obstructive jaundice that prevented the administration of chemotherapy. To elucidate mGPS values, serum levels of CRP and albumin were measured at the time of diagnosis (before biliary drainage). Overall survival was evaluated and risk factors, which contribute to overall survival, were examined.
Biliary drainage was performed in 15 patients. Using values obtained before biliary drainage, there were no significant differences in median survival time between patients with a mGPS of 0 and those with a mGPS of 1 or 2 (10.7 vs. 9.4 months; p = 0.757). However, using values obtained after biliary drainage, median survival time was significantly higher in patients with a mGPS of 0 than in those with a mGPS of 1 or 2 (11.4 vs. 4.7 months; p = 0.002). Multivariate analysis revealed that a mGPS of 1 or 2 (HR: 3.38; 95% CI: 1.35-8.46, p = 0.009), a carbohydrate antigen 19-9 >1000 U/mL (2.52; 1.22-5.23, p = 0.013), a performance status of 2 (7.68; 2.72-21.28, p = 0.001), carcinoembryonic antigen level >10 ng/mL (2.29; 1.13-4.61, p = 0.021) were independently associated with overall survival.
mGPS values obtained after biliary drainage appear to be a more reliable indicator of overall survival in patients with inoperable pancreatic cancer. |
| doi_str_mv | 10.1371/journal.pone.0178777 |
| format | Article |
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mGPS was calculated before and after biliary drainage in 47 consecutive patients with inoperable pancreatic cancer who were receiving chemotherapy. Biliary drainage was indicated for malignant obstructive jaundice that prevented the administration of chemotherapy. To elucidate mGPS values, serum levels of CRP and albumin were measured at the time of diagnosis (before biliary drainage). Overall survival was evaluated and risk factors, which contribute to overall survival, were examined.
Biliary drainage was performed in 15 patients. Using values obtained before biliary drainage, there were no significant differences in median survival time between patients with a mGPS of 0 and those with a mGPS of 1 or 2 (10.7 vs. 9.4 months; p = 0.757). However, using values obtained after biliary drainage, median survival time was significantly higher in patients with a mGPS of 0 than in those with a mGPS of 1 or 2 (11.4 vs. 4.7 months; p = 0.002). Multivariate analysis revealed that a mGPS of 1 or 2 (HR: 3.38; 95% CI: 1.35-8.46, p = 0.009), a carbohydrate antigen 19-9 >1000 U/mL (2.52; 1.22-5.23, p = 0.013), a performance status of 2 (7.68; 2.72-21.28, p = 0.001), carcinoembryonic antigen level >10 ng/mL (2.29; 1.13-4.61, p = 0.021) were independently associated with overall survival.
mGPS values obtained after biliary drainage appear to be a more reliable indicator of overall survival in patients with inoperable pancreatic cancer.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0178777</identifier><identifier>PMID: 28644836</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Aged ; Aged, 80 and over ; Albumin ; Antineoplastic Agents - therapeutic use ; Biology and Life Sciences ; Biomarkers, Tumor - blood ; Cancer ; Cancer diagnosis ; Cancer therapies ; Carbohydrates ; Carcinoembryonic antigen ; Carcinoembryonic Antigen - blood ; Care and treatment ; Chemotherapy ; Cholangitis ; Cholangitis - etiology ; Cholangitis - therapy ; Combined Modality Therapy ; Diagnosis ; Drainage ; Female ; Gastroenterology ; Humans ; Inflammation ; Internal medicine ; Jaundice ; Kaplan-Meier Estimate ; Male ; Medical diagnosis ; Medical prognosis ; Medicine ; Medicine and Health Sciences ; Metastasis ; Methods ; Multivariate Analysis ; Pancreatic cancer ; Pancreatic Neoplasms - blood ; Pancreatic Neoplasms - mortality ; Pancreatic Neoplasms - therapy ; Patients ; Physical Sciences ; Prognosis ; Proportional Hazards Models ; Research and Analysis Methods ; Retrospective Studies ; Risk analysis ; Risk Factors ; Serum levels ; Survival ; Survival Rate ; Treatment Outcome ; University graduates ; Wound drainage</subject><ispartof>PloS one, 2017-06, Vol.12 (6), p.e0178777-e0178777</ispartof><rights>COPYRIGHT 2017 Public Library of Science</rights><rights>2017 Iino et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2017 Iino et al 2017 Iino et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-94c553cb387cfb5faa6e9c0abc9bfff7389cecba2d3c2aa004cb87272ae7582d3</citedby><cites>FETCH-LOGICAL-c692t-94c553cb387cfb5faa6e9c0abc9bfff7389cecba2d3c2aa004cb87272ae7582d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482428/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482428/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,2103,2929,23871,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28644836$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Rocha, Flavio</contributor><creatorcontrib>Iino, Chikara</creatorcontrib><creatorcontrib>Shimoyama, Tadashi</creatorcontrib><creatorcontrib>Igarashi, Takasato</creatorcontrib><creatorcontrib>Aihara, Tomoyuki</creatorcontrib><creatorcontrib>Ishii, Kentaro</creatorcontrib><creatorcontrib>Sakamoto, Juichi</creatorcontrib><creatorcontrib>Tono, Hiroshi</creatorcontrib><creatorcontrib>Fukuda, Shinsaku</creatorcontrib><title>Biliary drainage improves the predictive value of modified Glasgow Prognostic Scores in inoperable pancreatic cancer</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>To assess the influence of biliary drainage to cholangitis on modified Glasgow Prognostic Score (mGPS) in patients with pancreatic cancer.
mGPS was calculated before and after biliary drainage in 47 consecutive patients with inoperable pancreatic cancer who were receiving chemotherapy. Biliary drainage was indicated for malignant obstructive jaundice that prevented the administration of chemotherapy. To elucidate mGPS values, serum levels of CRP and albumin were measured at the time of diagnosis (before biliary drainage). Overall survival was evaluated and risk factors, which contribute to overall survival, were examined.
Biliary drainage was performed in 15 patients. Using values obtained before biliary drainage, there were no significant differences in median survival time between patients with a mGPS of 0 and those with a mGPS of 1 or 2 (10.7 vs. 9.4 months; p = 0.757). However, using values obtained after biliary drainage, median survival time was significantly higher in patients with a mGPS of 0 than in those with a mGPS of 1 or 2 (11.4 vs. 4.7 months; p = 0.002). Multivariate analysis revealed that a mGPS of 1 or 2 (HR: 3.38; 95% CI: 1.35-8.46, p = 0.009), a carbohydrate antigen 19-9 >1000 U/mL (2.52; 1.22-5.23, p = 0.013), a performance status of 2 (7.68; 2.72-21.28, p = 0.001), carcinoembryonic antigen level >10 ng/mL (2.29; 1.13-4.61, p = 0.021) were independently associated with overall survival.
mGPS values obtained after biliary drainage appear to be a more reliable indicator of overall survival in patients with inoperable pancreatic cancer.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Albumin</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Biology and Life Sciences</subject><subject>Biomarkers, Tumor - blood</subject><subject>Cancer</subject><subject>Cancer diagnosis</subject><subject>Cancer therapies</subject><subject>Carbohydrates</subject><subject>Carcinoembryonic antigen</subject><subject>Carcinoembryonic Antigen - blood</subject><subject>Care and treatment</subject><subject>Chemotherapy</subject><subject>Cholangitis</subject><subject>Cholangitis - etiology</subject><subject>Cholangitis - therapy</subject><subject>Combined Modality Therapy</subject><subject>Diagnosis</subject><subject>Drainage</subject><subject>Female</subject><subject>Gastroenterology</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Internal medicine</subject><subject>Jaundice</subject><subject>Kaplan-Meier Estimate</subject><subject>Male</subject><subject>Medical diagnosis</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Metastasis</subject><subject>Methods</subject><subject>Multivariate Analysis</subject><subject>Pancreatic cancer</subject><subject>Pancreatic Neoplasms - blood</subject><subject>Pancreatic Neoplasms - mortality</subject><subject>Pancreatic Neoplasms - therapy</subject><subject>Patients</subject><subject>Physical Sciences</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Research and Analysis Methods</subject><subject>Retrospective Studies</subject><subject>Risk analysis</subject><subject>Risk Factors</subject><subject>Serum levels</subject><subject>Survival</subject><subject>Survival Rate</subject><subject>Treatment Outcome</subject><subject>University graduates</subject><subject>Wound drainage</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk1GL1DAQx4so3nn6DUQLgujDrm2SNsmLcB56LhyceOprmKbTbo5sU5N21W9v9rZ3bOUepIGGye__z2SSSZLnebbMKc_fXbvRd2CXvetwmeVccM4fJMe5pGRRkow-PJgfJU9CuM6ygoqyfJwcEVEyJmh5nAwfjDXg_6S1B9NBi6nZ9N5tMaTDGtPeY230YLaYbsGOmLom3bjaNAbr9NxCaN2v9It3befCYHR6pZ2PUtPF4Xr0UNloAp32CLt1HafonyaPGrABn03_k-T7p4_fzj4vLi7PV2enFwtdSjIsJNNFQXVFBddNVTQAJUqdQaVl1TQNp0Jq1BWQmmoCkGVMV4ITTgB5IWL0JHm59-2tC2oqWFC5zIlkBRNFJFZ7onZwrXpvNrEWyoFRNwHnWwU-Jm5R1VQWyHhBJa0Zr6uqZqgzLUXOJIOcRK_3025jtcFaYzd4sDPT-Upn1qp1WxUzIYyIaPBmMvDu54hhUBsTNFoLHbrxJm8akygFjeirf9D7TzdRLcQDmK5xcV-9M1WnTJYlYbTYUct7qPjVuDE6vq7GxPhM8HYmiMyAv4cWxhDU6urr_7OXP-bs6wN2jWCHdXB2HIzrwhxke1B7F4LH5q7IeaZ2zXFbDbVrDjU1R5S9OLygO9FtN9C_2HUMlA</recordid><startdate>20170623</startdate><enddate>20170623</enddate><creator>Iino, Chikara</creator><creator>Shimoyama, Tadashi</creator><creator>Igarashi, Takasato</creator><creator>Aihara, Tomoyuki</creator><creator>Ishii, Kentaro</creator><creator>Sakamoto, Juichi</creator><creator>Tono, Hiroshi</creator><creator>Fukuda, Shinsaku</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20170623</creationdate><title>Biliary drainage improves the predictive value of modified Glasgow Prognostic Scores in inoperable pancreatic cancer</title><author>Iino, Chikara ; Shimoyama, Tadashi ; Igarashi, Takasato ; Aihara, Tomoyuki ; Ishii, Kentaro ; Sakamoto, Juichi ; Tono, Hiroshi ; Fukuda, Shinsaku</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-94c553cb387cfb5faa6e9c0abc9bfff7389cecba2d3c2aa004cb87272ae7582d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Albumin</topic><topic>Antineoplastic Agents - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Iino, Chikara</au><au>Shimoyama, Tadashi</au><au>Igarashi, Takasato</au><au>Aihara, Tomoyuki</au><au>Ishii, Kentaro</au><au>Sakamoto, Juichi</au><au>Tono, Hiroshi</au><au>Fukuda, Shinsaku</au><au>Rocha, Flavio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biliary drainage improves the predictive value of modified Glasgow Prognostic Scores in inoperable pancreatic cancer</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2017-06-23</date><risdate>2017</risdate><volume>12</volume><issue>6</issue><spage>e0178777</spage><epage>e0178777</epage><pages>e0178777-e0178777</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>To assess the influence of biliary drainage to cholangitis on modified Glasgow Prognostic Score (mGPS) in patients with pancreatic cancer.
mGPS was calculated before and after biliary drainage in 47 consecutive patients with inoperable pancreatic cancer who were receiving chemotherapy. Biliary drainage was indicated for malignant obstructive jaundice that prevented the administration of chemotherapy. To elucidate mGPS values, serum levels of CRP and albumin were measured at the time of diagnosis (before biliary drainage). Overall survival was evaluated and risk factors, which contribute to overall survival, were examined.
Biliary drainage was performed in 15 patients. Using values obtained before biliary drainage, there were no significant differences in median survival time between patients with a mGPS of 0 and those with a mGPS of 1 or 2 (10.7 vs. 9.4 months; p = 0.757). However, using values obtained after biliary drainage, median survival time was significantly higher in patients with a mGPS of 0 than in those with a mGPS of 1 or 2 (11.4 vs. 4.7 months; p = 0.002). Multivariate analysis revealed that a mGPS of 1 or 2 (HR: 3.38; 95% CI: 1.35-8.46, p = 0.009), a carbohydrate antigen 19-9 >1000 U/mL (2.52; 1.22-5.23, p = 0.013), a performance status of 2 (7.68; 2.72-21.28, p = 0.001), carcinoembryonic antigen level >10 ng/mL (2.29; 1.13-4.61, p = 0.021) were independently associated with overall survival.
mGPS values obtained after biliary drainage appear to be a more reliable indicator of overall survival in patients with inoperable pancreatic cancer.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>28644836</pmid><doi>10.1371/journal.pone.0178777</doi><tpages>e0178777</tpages><oa>free_for_read</oa></addata></record> |
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| recordid | cdi_plos_journals_1912945485 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Aged Aged, 80 and over Albumin Antineoplastic Agents - therapeutic use Biology and Life Sciences Biomarkers, Tumor - blood Cancer Cancer diagnosis Cancer therapies Carbohydrates Carcinoembryonic antigen Carcinoembryonic Antigen - blood Care and treatment Chemotherapy Cholangitis Cholangitis - etiology Cholangitis - therapy Combined Modality Therapy Diagnosis Drainage Female Gastroenterology Humans Inflammation Internal medicine Jaundice Kaplan-Meier Estimate Male Medical diagnosis Medical prognosis Medicine Medicine and Health Sciences Metastasis Methods Multivariate Analysis Pancreatic cancer Pancreatic Neoplasms - blood Pancreatic Neoplasms - mortality Pancreatic Neoplasms - therapy Patients Physical Sciences Prognosis Proportional Hazards Models Research and Analysis Methods Retrospective Studies Risk analysis Risk Factors Serum levels Survival Survival Rate Treatment Outcome University graduates Wound drainage |
| title | Biliary drainage improves the predictive value of modified Glasgow Prognostic Scores in inoperable pancreatic cancer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-13T09%3A49%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Biliary%20drainage%20improves%20the%20predictive%20value%20of%20modified%20Glasgow%20Prognostic%20Scores%20in%20inoperable%20pancreatic%20cancer&rft.jtitle=PloS%20one&rft.au=Iino,%20Chikara&rft.date=2017-06-23&rft.volume=12&rft.issue=6&rft.spage=e0178777&rft.epage=e0178777&rft.pages=e0178777-e0178777&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0178777&rft_dat=%3Cgale_plos_%3EA496624355%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1912945485&rft_id=info:pmid/28644836&rft_galeid=A496624355&rft_doaj_id=oai_doaj_org_article_d395e475393d47dbbd4ec0c981494a12&rfr_iscdi=true |