TRPA1 and TRPV1 contribute to propofol-mediated antagonism of U46619-induced constriction in murine coronary arteries

Transient receptor potential (TRP) ion channels have emerged as key components contributing to vasoreactivity. Propofol, an anesthetic is associated with adverse side effects including hypotension and acute pain upon infusion. Our objective was to determine the extent to which TRPA1 and/or TRPV1 ion...

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Veröffentlicht in:	PloS one 2017-06, Vol.12 (6), p.e0180106-e0180106
Hauptverfasser:	Sinharoy, Pritam, Bratz, Ian N, Sinha, Sayantani, Showalter, Loral E, Andrei, Spencer R, Damron, Derek S
Format:	Artikel
Sprache:	eng
Schlagworte:	15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid - antagonists & inhibitors 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid - pharmacology Anesthesia Animals Arteries Arterioles Balancing Biological products Biology and Life Sciences Blood vessels Bone surgery Capsaicin receptors Cardiovascular disease Cells, Cultured Cellular signal transduction Cold Complications and side effects Constrictions Coronary artery Coronary vessels Coronary Vessels - drug effects Coronary Vessels - metabolism Dosage and administration Endothelial Cells - drug effects Endothelial Cells - metabolism Endothelium Gene expression Genetic aspects Hypotension In vitro methods and tests Inhibition Ion channels Kinases Laboratory animals Large-Conductance Calcium-Activated Potassium Channel alpha Subunits - metabolism Male Medicine and Health Sciences Mice Mice, Inbred C57BL Mice, Knockout Microvasculature Microvessels - drug effects Microvessels - metabolism NG-Nitroarginine methyl ester Nitric Oxide Synthase Type III - metabolism Nitric-oxide synthase Pain Physical Sciences Physiological aspects Propofol Propofol - pharmacology Research and Analysis Methods Rodents Side effects Studies Temperature effects Transient Receptor Potential Channels - genetics Transient Receptor Potential Channels - metabolism Transient receptor potential proteins TRPA1 Cation Channel TRPV Cation Channels - genetics TRPV Cation Channels - metabolism Vasoconstrictor Agents - antagonists & inhibitors Vasoconstrictor Agents - pharmacology Vasodilation Vasodilation - drug effects Vasodilation - physiology Vasodilator Agents - pharmacology Veins & arteries
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