Psychotic symptoms in older people without dementia from a Brazilian community-based sample: A seven years' follow-up
Studies of the incidence of psychotic symptoms in elderly people at risk of dementia are scarce. This is a seven year follow up study aiming to determine the incidence of psychotic symptoms and their correlation with other clinical aspects, in particular the rate of development of cognitive impairme...
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| description | Studies of the incidence of psychotic symptoms in elderly people at risk of dementia are scarce. This is a seven year follow up study aiming to determine the incidence of psychotic symptoms and their correlation with other clinical aspects, in particular the rate of development of cognitive impairment.
Cohort study of a community-based sample of elderly subjects. At study entry in 2004, the sample was composed of 1,125 individuals aged 60 years and older. Of this total, 547 subjects were re-evaluated in 2011 and submitted to the original study protocol. Of these, 199 showed no psychotic symptoms at phase I, while 64 already had psychotic symptoms in 2004.
The incidence of at least one psychotic symptom in the 7 year period was 8.0% (Visual/tactile hallucinations: 4.5%; Persecutory delusions: 3.0%; Auditory hallucinations: 2.5%). Development of psychotic symptoms was associated with epilepsy (OR: 7.75 and 15.83), lower MMSE (OR: 0.72) and reported depression (OR: 6.48). A total of 57.8% of individuals with psychotic symptoms developed cognitive impairment after 7 years. Visual/tactile hallucinations were the only psychotic symptom predictive of this impairment, which was related to lower MMSE and greater functional impairment.
The incidence of psychotic symptoms and the conversion rate to cognitive impairment was in the upper range when compared with previous reports. Visual/tactile hallucinations were the most frequent symptoms and were predictive of cognitive impairment over the 7 year period. A significant relationship was found between the incidence of psychotic symptoms and low MMSE scores, as well as clinical comorbities such as epilepsy, reported depression, diabetes and syphilis. |
| doi_str_mv | 10.1371/journal.pone.0178471 |
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Cohort study of a community-based sample of elderly subjects. At study entry in 2004, the sample was composed of 1,125 individuals aged 60 years and older. Of this total, 547 subjects were re-evaluated in 2011 and submitted to the original study protocol. Of these, 199 showed no psychotic symptoms at phase I, while 64 already had psychotic symptoms in 2004.
The incidence of at least one psychotic symptom in the 7 year period was 8.0% (Visual/tactile hallucinations: 4.5%; Persecutory delusions: 3.0%; Auditory hallucinations: 2.5%). Development of psychotic symptoms was associated with epilepsy (OR: 7.75 and 15.83), lower MMSE (OR: 0.72) and reported depression (OR: 6.48). A total of 57.8% of individuals with psychotic symptoms developed cognitive impairment after 7 years. Visual/tactile hallucinations were the only psychotic symptom predictive of this impairment, which was related to lower MMSE and greater functional impairment.
The incidence of psychotic symptoms and the conversion rate to cognitive impairment was in the upper range when compared with previous reports. Visual/tactile hallucinations were the most frequent symptoms and were predictive of cognitive impairment over the 7 year period. A significant relationship was found between the incidence of psychotic symptoms and low MMSE scores, as well as clinical comorbities such as epilepsy, reported depression, diabetes and syphilis.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0178471</identifier><identifier>PMID: 28622335</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Activities of daily living ; Age ; Aged ; Aged, 80 and over ; Auditory perception ; Biology and Life Sciences ; Brazil - epidemiology ; Clinical aspects ; Cognitive ability ; Cognitive Dysfunction - epidemiology ; Cognitive Dysfunction - psychology ; Communities ; Complications and side effects ; Conversion ; Correlation analysis ; Dementia ; Dementia - epidemiology ; Dementia - psychology ; Dementia disorders ; Demographic aspects ; Depression - epidemiology ; Depression - psychology ; Diabetes mellitus ; Epilepsy ; Female ; Follow-Up Studies ; Functional anatomy ; Geriatrics ; Hallucinations ; Hallucinations - epidemiology ; Hallucinations - psychology ; Humans ; Impairment ; Incidence ; Male ; Medicine and Health Sciences ; Mental depression ; Middle Aged ; Older people ; People and Places ; Psychiatry ; Psychological aspects ; Psychological symptoms ; Psychosis ; Psychotic Disorders - epidemiology ; Psychotic Disorders - psychology ; Risk ; Risk factors ; Sexually transmitted diseases ; Social Sciences ; STD ; Syphilis ; Tactile ; Visual perception</subject><ispartof>PloS one, 2017-06, Vol.12 (6), p.e0178471-e0178471</ispartof><rights>COPYRIGHT 2017 Public Library of Science</rights><rights>2017 Soares et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2017 Soares et al 2017 Soares et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-8e14f611a2ec22dc8f8723932079b3e2763acc99b650472eef30f6be16c184d3</citedby><cites>FETCH-LOGICAL-c692t-8e14f611a2ec22dc8f8723932079b3e2763acc99b650472eef30f6be16c184d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473532/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473532/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79570,79571</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28622335$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Soares, Walter Barbalho</creatorcontrib><creatorcontrib>Dos Santos, Eriton Barros</creatorcontrib><creatorcontrib>Bottino, Cássio Machado de Campos</creatorcontrib><creatorcontrib>Elkis, Helio</creatorcontrib><title>Psychotic symptoms in older people without dementia from a Brazilian community-based sample: A seven years' follow-up</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Studies of the incidence of psychotic symptoms in elderly people at risk of dementia are scarce. This is a seven year follow up study aiming to determine the incidence of psychotic symptoms and their correlation with other clinical aspects, in particular the rate of development of cognitive impairment.
Cohort study of a community-based sample of elderly subjects. At study entry in 2004, the sample was composed of 1,125 individuals aged 60 years and older. Of this total, 547 subjects were re-evaluated in 2011 and submitted to the original study protocol. Of these, 199 showed no psychotic symptoms at phase I, while 64 already had psychotic symptoms in 2004.
The incidence of at least one psychotic symptom in the 7 year period was 8.0% (Visual/tactile hallucinations: 4.5%; Persecutory delusions: 3.0%; Auditory hallucinations: 2.5%). Development of psychotic symptoms was associated with epilepsy (OR: 7.75 and 15.83), lower MMSE (OR: 0.72) and reported depression (OR: 6.48). A total of 57.8% of individuals with psychotic symptoms developed cognitive impairment after 7 years. Visual/tactile hallucinations were the only psychotic symptom predictive of this impairment, which was related to lower MMSE and greater functional impairment.
The incidence of psychotic symptoms and the conversion rate to cognitive impairment was in the upper range when compared with previous reports. Visual/tactile hallucinations were the most frequent symptoms and were predictive of cognitive impairment over the 7 year period. A significant relationship was found between the incidence of psychotic symptoms and low MMSE scores, as well as clinical comorbities such as epilepsy, reported depression, diabetes and syphilis.</description><subject>Activities of daily living</subject><subject>Age</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Auditory perception</subject><subject>Biology and Life Sciences</subject><subject>Brazil - epidemiology</subject><subject>Clinical aspects</subject><subject>Cognitive ability</subject><subject>Cognitive Dysfunction - epidemiology</subject><subject>Cognitive Dysfunction - psychology</subject><subject>Communities</subject><subject>Complications and side effects</subject><subject>Conversion</subject><subject>Correlation analysis</subject><subject>Dementia</subject><subject>Dementia - epidemiology</subject><subject>Dementia - psychology</subject><subject>Dementia disorders</subject><subject>Demographic aspects</subject><subject>Depression - epidemiology</subject><subject>Depression - psychology</subject><subject>Diabetes mellitus</subject><subject>Epilepsy</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Functional anatomy</subject><subject>Geriatrics</subject><subject>Hallucinations</subject><subject>Hallucinations - epidemiology</subject><subject>Hallucinations - psychology</subject><subject>Humans</subject><subject>Impairment</subject><subject>Incidence</subject><subject>Male</subject><subject>Medicine and Health Sciences</subject><subject>Mental depression</subject><subject>Middle Aged</subject><subject>Older people</subject><subject>People and Places</subject><subject>Psychiatry</subject><subject>Psychological aspects</subject><subject>Psychological symptoms</subject><subject>Psychosis</subject><subject>Psychotic Disorders - epidemiology</subject><subject>Psychotic Disorders - psychology</subject><subject>Risk</subject><subject>Risk factors</subject><subject>Sexually transmitted diseases</subject><subject>Social Sciences</subject><subject>STD</subject><subject>Syphilis</subject><subject>Tactile</subject><subject>Visual perception</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk0tv1DAUhSMEoqXwDxBYQuKxyOBH4jgskIaKx0iViqBiaznOzYwrJw520jL8ejxMWk1QFyiLRPZ3zvU9zk2SpwQvCCvI20s3-k7ZRe86WGBSiKwg95JjUjKacorZ_YPvo-RRCJcY50xw_jA5ooJTylh-nIxfw1Zv3GA0Ctu2H1wbkOmQszV41IPrLaBrM2zcOKAaWugGo1DjXYsU-uDVb2ON6pB2bTt2ZtimlQpQo6DaKHyHlijAFXRoC8qHV6hx1rrrdOwfJw8aZQM8md4nycWnjxenX9Kz88-r0-VZqnlJh1QAyRpOiKKgKa21aERBWWwKF2XFgBacKa3LsuI5zgoK0DDc8AoI10RkNTtJnu9te-uCnAILkpQEZwILXkRitSdqpy5l702r_FY6ZeTfBefXUvkYjgXJaVkTzBlVUGXxWCXNBDCqayLySvAqer2fqo1VC7WOWXllZ6bznc5s5NpdyTwrWM5oNHg9GXj3c4QwyNYEDdaqDty4P3dRlqQUEX3xD3p3dxO1VrEB0zUu1tU7U7nMyrzAHGe7sos7qPjE-zY6_l2NieszwZuZIDID_BrWagxBrr5_-3_2_MecfXnAbkDZYROcHQfjujAHsz2ovQvBQ3MbMsFyNxw3acjdcMhpOKLs2eEF3YpupoH9ASn-Cfs</recordid><startdate>20170616</startdate><enddate>20170616</enddate><creator>Soares, Walter Barbalho</creator><creator>Dos Santos, Eriton Barros</creator><creator>Bottino, Cássio Machado de Campos</creator><creator>Elkis, Helio</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20170616</creationdate><title>Psychotic symptoms in older people without dementia from a Brazilian community-based sample: A seven years' follow-up</title><author>Soares, Walter Barbalho ; Dos Santos, Eriton Barros ; Bottino, Cássio Machado de Campos ; Elkis, Helio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-8e14f611a2ec22dc8f8723932079b3e2763acc99b650472eef30f6be16c184d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Activities of daily living</topic><topic>Age</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Auditory perception</topic><topic>Biology and Life Sciences</topic><topic>Brazil - epidemiology</topic><topic>Clinical aspects</topic><topic>Cognitive ability</topic><topic>Cognitive Dysfunction - epidemiology</topic><topic>Cognitive Dysfunction - psychology</topic><topic>Communities</topic><topic>Complications and side effects</topic><topic>Conversion</topic><topic>Correlation analysis</topic><topic>Dementia</topic><topic>Dementia - epidemiology</topic><topic>Dementia - psychology</topic><topic>Dementia disorders</topic><topic>Demographic aspects</topic><topic>Depression - epidemiology</topic><topic>Depression - psychology</topic><topic>Diabetes mellitus</topic><topic>Epilepsy</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Functional anatomy</topic><topic>Geriatrics</topic><topic>Hallucinations</topic><topic>Hallucinations - epidemiology</topic><topic>Hallucinations - psychology</topic><topic>Humans</topic><topic>Impairment</topic><topic>Incidence</topic><topic>Male</topic><topic>Medicine and Health Sciences</topic><topic>Mental depression</topic><topic>Middle Aged</topic><topic>Older people</topic><topic>People and Places</topic><topic>Psychiatry</topic><topic>Psychological aspects</topic><topic>Psychological symptoms</topic><topic>Psychosis</topic><topic>Psychotic Disorders - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Soares, Walter Barbalho</au><au>Dos Santos, Eriton Barros</au><au>Bottino, Cássio Machado de Campos</au><au>Elkis, Helio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Psychotic symptoms in older people without dementia from a Brazilian community-based sample: A seven years' follow-up</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2017-06-16</date><risdate>2017</risdate><volume>12</volume><issue>6</issue><spage>e0178471</spage><epage>e0178471</epage><pages>e0178471-e0178471</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Studies of the incidence of psychotic symptoms in elderly people at risk of dementia are scarce. This is a seven year follow up study aiming to determine the incidence of psychotic symptoms and their correlation with other clinical aspects, in particular the rate of development of cognitive impairment.
Cohort study of a community-based sample of elderly subjects. At study entry in 2004, the sample was composed of 1,125 individuals aged 60 years and older. Of this total, 547 subjects were re-evaluated in 2011 and submitted to the original study protocol. Of these, 199 showed no psychotic symptoms at phase I, while 64 already had psychotic symptoms in 2004.
The incidence of at least one psychotic symptom in the 7 year period was 8.0% (Visual/tactile hallucinations: 4.5%; Persecutory delusions: 3.0%; Auditory hallucinations: 2.5%). Development of psychotic symptoms was associated with epilepsy (OR: 7.75 and 15.83), lower MMSE (OR: 0.72) and reported depression (OR: 6.48). A total of 57.8% of individuals with psychotic symptoms developed cognitive impairment after 7 years. Visual/tactile hallucinations were the only psychotic symptom predictive of this impairment, which was related to lower MMSE and greater functional impairment.
The incidence of psychotic symptoms and the conversion rate to cognitive impairment was in the upper range when compared with previous reports. Visual/tactile hallucinations were the most frequent symptoms and were predictive of cognitive impairment over the 7 year period. A significant relationship was found between the incidence of psychotic symptoms and low MMSE scores, as well as clinical comorbities such as epilepsy, reported depression, diabetes and syphilis.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>28622335</pmid><doi>10.1371/journal.pone.0178471</doi><tpages>e0178471</tpages><oa>free_for_read</oa></addata></record> |
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| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Activities of daily living Age Aged Aged, 80 and over Auditory perception Biology and Life Sciences Brazil - epidemiology Clinical aspects Cognitive ability Cognitive Dysfunction - epidemiology Cognitive Dysfunction - psychology Communities Complications and side effects Conversion Correlation analysis Dementia Dementia - epidemiology Dementia - psychology Dementia disorders Demographic aspects Depression - epidemiology Depression - psychology Diabetes mellitus Epilepsy Female Follow-Up Studies Functional anatomy Geriatrics Hallucinations Hallucinations - epidemiology Hallucinations - psychology Humans Impairment Incidence Male Medicine and Health Sciences Mental depression Middle Aged Older people People and Places Psychiatry Psychological aspects Psychological symptoms Psychosis Psychotic Disorders - epidemiology Psychotic Disorders - psychology Risk Risk factors Sexually transmitted diseases Social Sciences STD Syphilis Tactile Visual perception |
| title | Psychotic symptoms in older people without dementia from a Brazilian community-based sample: A seven years' follow-up |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-13T07%3A41%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Psychotic%20symptoms%20in%20older%20people%20without%20dementia%20from%20a%20Brazilian%20community-based%20sample:%20A%20seven%20years'%20follow-up&rft.jtitle=PloS%20one&rft.au=Soares,%20Walter%20Barbalho&rft.date=2017-06-16&rft.volume=12&rft.issue=6&rft.spage=e0178471&rft.epage=e0178471&rft.pages=e0178471-e0178471&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0178471&rft_dat=%3Cgale_plos_%3EA495706042%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1910480867&rft_id=info:pmid/28622335&rft_galeid=A495706042&rft_doaj_id=oai_doaj_org_article_629d10632aeb44f69248e32cd185b86b&rfr_iscdi=true |