Acute 40% exchange-transfusion with hemoglobin-vesicles in a mouse pneumonectomy model

Hemoglobin vesicles (HbVs) function as a red blood cell (RBC) substitute and are composed of purified hemoglobin encapsulated in a phospholipid bilayer membrane. The performance of HbVs as a substitute for RBC transfusions was examined in a mouse model of pneumonectomy following acute 40% exchange-t...

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Veröffentlicht in:	PloS one 2017-06, Vol.12 (6), p.e0178724-e0178724
Hauptverfasser:	Kohno, Mitsutomo, Ikeda, Tatsuhiko, Hashimoto, Ryo, Izumi, Yotaro, Watanabe, Masazumi, Horinouchi, Hirohisa, Sakai, Hiromi, Kobayashi, Koichi, Iwazaki, Masayuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Albumin Animals Biology and Life Sciences Blood Blood Component Transfusion - methods Blood groups Blood Substitutes - pharmacology Blood transfusion Blood volume Comparative analysis Encapsulation Erythrocytes Exchanging Functional anatomy Glycosylated hemoglobin Hemoglobin Hemoglobins - pharmacokinetics Human serum albumin Humans Hypoxia Hypoxia-inducible factor 1 Hypoxia-inducible factors Inflammation Injuries Kidneys Lipids Lungs Mathematical models Medicine Medicine and Health Sciences Methods Mice Oxygen Phospholipids Physiological aspects Pneumonectomy Recovery Recovery of function Research and Analysis Methods Respiratory function Rodents Serum albumin Staining Surgery Survival Thoracic surgery Transfusion Vesicles
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